Physio lecture body fluid compartments and transport

Total Body Water =?

60% of BW

How much total body water does a 20 kg dog have?

20kg x 0.6 = 12kg =12 L (liters or mL because talking about a fluid)

Intracellular fluid = ?

40% of BW

Lean animals have a higher have a ____________ amount of body water than obese animals

higher

Extracellular fluid =?

20% BW

(Within extracellular fluid) interstitial fluid?

16%

(Within extracellular fluid) plasma=?

4%

Body volume = ?

6-8% or 60-80 mL/Kg BW

What is the ECF volume of a 105kg pig?

105kg x .2 = 21L or 21,000 mL

Average blood volume =?

70 mL/Kg BW

Memorize Numbers in the chart important **

Mole =

Amount of substance

Equivalent=

Amount of electrical charge

Osmole=?

Number of dissolved particles

Important ** Measure CONCENTRATIONS in mol/L or mmol/L, mEq/L, Osm/L or mOsm/L

Know this

What does osmolarity determine clincially

Determines water movement between compartments

What is electroneutrality

When each body fluid compartment, total positive charges must equal total negative charges.

major ions in ECF

Cations=

Anions=

Na+

Cl- and HCO3 -

Major ions in ICF

Cations=

Anions=

K+

Proteins and organic phosphates

**** slide 6 Osmolarity same in ECF and ICF —> electroneutrality maintained

290- 300 mOsm/L

Na+/K+ ATPase pump does what (uses ATP)

Pumps Na+ out of the cell

Ca2+/ATPase pump (uses ATP)

Pumps a out of cells

What allows nerve and muscle cells to have a resting membrane potentials

K+ difference

What allows upstroke of action potentials in nerve and muscle cells, and absorption of nutrients due to

Na+ differences

Excitation contration coupling in muscle cells depends of what

Ca2+ differences

cell membranes are ______ permeable

Selectively

ransporters for glucose, amino acids, Ca2+, H+ utilize Na+ gradient, but dont directly use energy→ ?

secondary transporters

Cell membrane characteristics

Composed of lipids and proteins