Infants (1month-1yr) & Communicable Diseases

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Infants (1month-1yr) & Communicable Diseases

Last updated 4:17 PM on 9/7/26
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1
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What are the growth charts used for biological development?

Birth → <2 years = WHO

2 → 20 years = CDC

Weight gain:

  • 6 months → 2x birth weight

  • 12 months → 3x birth weight

Daily weight gain:

  • 0-3 months = 30 g/day

  • 3-6 months = 20 g/day

  • 6-12 months = 10 g/day

Length growth

  • Birth → 6 months = 1 in/month

  • 6-12 months = ½ in/month


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Important physical changes during infancy time

Posterior fontanel closes by 2 months

Breathing:

  • Slowly start breathing via nose + mouth

Reflexes:

  • Moro, Stepping, Rooting fade by 4-6 months

Teeth:

  • Deciduous (primary) teeth begin to erupt

  • Begins growing chewing/biting skills

Gross motor skills: Utilizes large muscle groups

  • Rolling

  • Sitting

  • Crawling

  • Standing

  • Walking

Infant develops from head to toes

  • Cephacaudal/Proximodistal

    • Arm → Hand → Fingers


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Gross Motor Milestones:


1 month → Turn head while supine

  • Head lag: poor head control when turning infant from lying to other position

2 month → Hold head up while on tummy; moves arms & legs

4 months → Holds head w/out support; pushes onto elbows/forearms

  • Commando crawling: use of arms/upper body to move along floor

6 months → Rolls tummy → back; pushes up w/straight arms; supports self w/hands while sitting

9 months → Goes sitting position by self; sits w/out support

12 months → pulls to stand; cruises along furniture

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Grasp progression:

1 month → tight fist

2 month → briefly opens hands

4 months → crude palmar grasp

  • Using palm w/out thumb to grasp objects

  • Hold toys placed in hand

  • Brings hand to mouth

7 months → radial palmar grasp

  • fingers + opposing thumb

8 months → scissors grasp

  • Side of index fingers + thumb

9 months → transfer from hand to hand

  • Uses fingers to rake food

11 months → shake + throw objects

12 months → pincer grasp

  • Thumbs + index fingers

  • drinks from uncovered cup


<p>1 month → tight fist</p><p>2 month → briefly opens hands</p><p>4 months → crude palmar grasp</p><ul><li><p>Using palm w/out thumb to grasp objects</p></li><li><p>Hold toys placed in hand</p></li><li><p>Brings hand to mouth</p></li></ul><p>7 months → radial palmar grasp</p><ul><li><p>fingers +  opposing thumb</p></li></ul><p>8 months → scissors grasp</p><ul><li><p>Side of index fingers + thumb</p></li></ul><p>9 months → transfer from hand to hand</p><ul><li><p>Uses fingers to rake food </p></li></ul><p>11 months → shake + throw objects</p><p>12 months → pincer grasp</p><ul><li><p>Thumbs + index fingers</p></li><li><p>drinks from uncovered cup</p></li></ul><p></p>
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When does stranger anxiety ususally occur and what they do?

9 months

Shy, clingy, cry, fearful

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Object permannce?

Understanding that a person/object keeps existing despite it not being seen

  • Peek-a boo

  • 6-12 months


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Psychosocial milestones:

2 months → relaxes when picked up or spoken too

  • smiles socially

  • looks at faces

4 months → Smiles for attention, chuckles

  • Makes sounds/things to keep attention

6 months → recognizes people

  • enjoys mirror

  • laughts

9 months → Stranger anxiety

  • Facial expressions

  • Responds to name

  • Separation reaction

  • Understands & enjoys peek-a-boo

12 months → Plays interactive games (pat-a-cake)

  • proto-imperative pointing

    • Aka “I want THAT”


Starts also developing memory, language, reasoning, thinking, attention

  • If i do X → Y happens “cause and effect”


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Screen time:

AAP: no screen time up to 18 months

WHO: none till 2 years or more

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Cognitive Development Milestones:

1-2 months:

  • Optical focal length of ~10 inches

  • Responds to stimuli changes; fixates on objects (tracks them horizontally and slightly beyond midline”

  • Uses sucking and grasping reflex to interact

2-6 months:

  • Begins exploring via touch

  • Stares at hands, touches body, explores senses = all contribute to cause/effect learning

6-12 months:

  • Reaches for, inspects, holds, drops, manipulates, uses for purpose, mouth places objects


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Language development + milestones

Hearing → interaction → association → communication

  • More infant hears, more it develops

  • Parent interaction:

    • Talking/Reading/Responding to them

    • Labeling objects

MIlestones:

  • 2 months: makes sounds other than crying

    • Reacts to LOUD sounds

  • 4 months: Cooing; makes sounds back; turns toward voices

  • 6 months: Takes turns making sounds

    • Blows raspberries

    • Squeals

  • 9 months: mamamama/babababba

    • Raises arms to be picked up

  • 12 months:

    • waves bye

    • “Mama/dada”

    • Understands “no”


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Play in Infants

Social smile: first sign of play

  • Develops at 4-6 weeks

  • After 4 months → regular smiling +cooing

  • 3-6 months → seeks interaction and play

Avoid teasing and throwing things during this age

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PPD:

Sadness, Guilt, Imcompetence, Anhedonia, Anxiety, Self-harm

May lead to:

  • Developmental, Emotional, Language, Cognitive Delays

  • Poor bonding

Interventions:

  • Provide support

  • Sleep routines

  • Self-help


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Separation Anxiety:

Normal dev stage

  • 6 months → 3 years

    • 9 months = strongest anxiety

  • Appears suddenly → intensifies → gradually resolves

  • Crying, Screaming, Clinging, Refusal to separate

Prolonged can lead to:

  • Constant fear, loss of securiy

  • poor bonding and social interactions

  • Poor feeding

Interventions: Gradual separation

  1. Leave for a short period

  2. Use a trusted caregiver

  3. Keep infant in familiar place

  4. Gradually increase time away

  5. Return


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Bowlby’s Attachment Theory:

Attachment-related stress → physical response

  • Tachycardia


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Foundation of Infant Health Promotion:

Safety:

  • Risks:

    • Suffocation, Falls, Burns, Chocking, Drowning

  • Interventions:

    • Cover outlets, pad sharp edges, locks, supervise

    • CPR and hemlicks

      • Alternating back blows + chest thrusts

Nutrition:

  • Birth → 4-6 months

    • Formula feeding: 18-20 kcal/oz

      • use w/in 2 hrs of mixing OR keep in fridge for up to 1 day

    • Breast feeding: 18-20 kcal/oz

  • Always discard left overs as it can grow bacteria

  • ~6 months: slowly transition to solid food

    • Tongue-thrust reflex slowly decreases

    • One new fee q3-5 days

  • Sippy cup: water is good when infant can use palmar graps

  • Honey → ^ r/x for botulism


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Food sensitivity

Cow’s milk, Eggs, Peanuts, Soy, Wheat → GI upset, ezcema, asthma

  • When introducing new foods, wait 3-5 days

  • AVOID HONEY when <1 year


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Nutrition needs Infants:

100kcal/kg/day

  • 40-60kcal/kg/day for metabolic processes

  • Premature, illness, genetic disorders → ^ energy needs

Start 20-30 mL/kg → increase w/in 7-10 days

  • colostrum → breast milk


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Food Aversion:

Pain + Trauma + Fear

  • GERD: feeding → pain → aversion

  • NICU: mouth swabbing, pacifiers, oral procedures

  • Fear

Intervention:

  • Non-nutritive sucking → Pacifier

  • Breast for non-nutritive sucking

  • Cue-based feeding

  • Sweet taste to milk

  • Improve positive oral experiences at home


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Vitamins + Minerals for Infants:

Iron:

  • Helps for hemo and myoglobin formation

  • v = cognitive and psychomotor issues

  • Iron deficiency common in:

    • Premature infants

    • Exclusively breastfed

    • Non-iron fortified formula

  • START GIVING AT 4 months

    • Until iron-fortified cereal or meats are added to diet

Ferrous sulfate:

  • Prevents/treats iron deficiency anemia

  • A/E:

    • Constipation, Diarrhea

    • Nausea & Vomiting

    • Abd pain, Green/Dark stools

    • Anorexia, Gas

  • Toom much iron = fatal

Vitamin D:

  • Deficiency most common in exclusively breastfed infants

  • Uses:

    • Calcium, phosphate absorption and uptake

    • Increases Calcium availability in blood

  • Start supplementing right after birth

    • Use a dropper to avoid dosing errors

  • Toxicity A/E: “hypervitaminosis D”

    • Nausea, Vomiting

    • Irritable, Fatigue

    • Poor feeding, weak, weight loss, dehydration

Vitamin B12:

  • May require ife parents are vegan/vegitarian diet


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Sleep for infants and alterations in them:

Normal amount for sleep:

  • < 3 months = 16-17 hours

  • 6 months - 1 year = 13-14 hours

Sleep amount factors:

  • Temperament

    • Poor self-soothing

    • Cries often

  • Environment:

    • Loud, crowded, activity, no routines

Allow opportunities for infant to self sooth

  • Don’t necessarly rush to soothe for every cry


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Faliure to Thrive:

When infant does not effectively or receive enery for growth

  • Low intake

  • High energy expenditure

  • Low Absorption

Causes:

  • Malabsorption syndrome

  • CF, Congenital heart defects

  • Respiratory or Metabolic Disorders

  • Neglect, poor parent educatiion

    • Possible Post partum depression occuring

D/x:

  • Anthropometric Z-scores:

    • Compares weight for length AND BMI for age

    • The more negative z score it is = greater malnutrition degree


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Sudden Unexpected Infant Death (SUID):

Umbrella term for unexpected intant death (<1 years old)

  • SIDS:

  • Accidental suffocation and strangulation in Bed

Risk:

  • Maternal:

    • Age <20

    • Smokes, Lack of prenatal care

  • Infant:

    • Premature, Low birth weight, Overheating

    • 2ndhand smoke, eating too much

    • Prone sleeping, soft mattress, loose bedding

    • Sleeping on cushined surface (couch)

Pacifiers may help despite not being fully understood why

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PN Scope of Practice regarding Immunizations:

  • Collect screening data & help find missed/upcomming ones

  • Assist w/immunizations

  • Reinforce education

  • Monitor A/E

  • Maintain records


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Nationally Notifiable Diseases:

Resp/Neuro:

  • Diphteria

  • Pertussis

  • Meningoccall disease

  • H. Influenza

  • Poliovirus

Hepatitis:

  • A,B,C

Vaccine Preventable ones:

  • Rubella

  • Tetanus

  • Varicella

  • Diphtheria

  • Pertussis

  • Poliovirus


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Precaution’s Examples:

Contact:

  • Scabies, excessive wound drainage

  • C.diff

  • VRE, MRSA

Droplet:

  • Pertussis, INfluenza

  • Menignitis, Adenovirus

  • Rhinovirus

  • Group A Strep

Airborne:

  • TB,SARS-CoV

  • Rubeola

  • Varicella


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Donning + Doffing PPE

1⃣ Hand hygiene → 2⃣ Gown → 3⃣ Mask/respirator → 4⃣ Goggles/face shield → 5⃣ Gloves


Gloves → Goggles/Face shield → Gown →Mask → Hand Hygiene

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Varicella/Chicken Pox

Spread via airborn droplets

  • Fluid from vesicles

  • AIRBORNE + CONTACT

    • Pregnant nurses should avoid caring for these childs

  • Usually remains latent in sensory nerves and later reactivated as shingles

S/s:

  • Itchy fluid-filled vessicles → scabs

    • Chest, back face

    • Later → mouth, eyelids, g3nitals, scalp

  • Fever, fatigue, sore throat, headache

T/x:

  • Acetaminophen → fever/pain

  • Calamine lotion, Oatmeal baths

  • Antihistamine → itching

    • Benadryl A/E:

      • Drowsy, Dry mouth, v BP

      • Avoid combination of oral w/topical dyphenhydramine

  • Fluid intake

Edu:

  • Avoid scratching via:

    • Keep nails short, cotton clothing, avoid overheating

    • Fluid intake, cool baths

  • Varicella is no longer contagious when → all lesions are crusted and dried

  • Take vaccine in 2 doses


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Diphetheria:

Produces a strong exotoxin →

  • Local inflammation, Sore throat, fever, cervical lymphadenopathy

  • Gray pseudomebrane: takes around 2-5 days for incubation

    • Throat, Tonsils, Pharynx → thickens → Airway obstruction

  • Myocarditis, Neuritis

D/x:

  • Throat culture, PCR, toxin testing

T/x:

  • Isolation → Antibiotics → Diphtheria antitoxin (DAT)

    • Ezythromycin & Penicillin G

    • Before giving DAT, a/x hypersensitivity → ^ r/x for anaphylaxis

      • Urticaria risk too

Edu:

  • Soft diet due to odynophagia

  • Fluids, quiet/restful place

  • Keep airway open


<p>Produces a strong exotoxin →</p><ul><li><p>Local inflammation, Sore throat, fever, cervical lymphadenopathy</p></li><li><p>Gray pseudomebrane: takes around 2-5 days for incubation</p><ul><li><p>Throat, Tonsils, Pharynx → thickens → Airway obstruction</p></li></ul></li><li><p><mark data-color="yellow" style="background-color: yellow; color: inherit;">Myocarditis, Neuritis</mark></p></li></ul><p>D/x:</p><ul><li><p>Throat culture, PCR, toxin testing</p></li></ul><p>T/x:</p><ul><li><p>Isolation → Antibiotics → Diphtheria antitoxin (DAT)</p><ul><li><p>Ezythromycin &amp; Penicillin G</p></li><li><p>Before giving DAT, a/x hypersensitivity → ^ r/x for anaphylaxis</p><ul><li><p>Urticaria risk too</p></li></ul></li></ul></li></ul><p>Edu:</p><ul><li><p>Soft diet due to odynophagia</p></li><li><p>Fluids, quiet/restful place</p></li><li><p>Keep airway open</p></li></ul><p></p>
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Mumps:

From paramyxovirus via respiratory droplets, contact w/saliva, or fomites

  • 7-21 days for incubation

  • MMR vaccine to prevent

  • Contagious when:

    • 1-2 days before s/s

    • 5 days after s/s

S/s:

  • Parotitis: swelling of parotid glands; uni/bilateral

  • Fever, Headaches, Fatigue, Myalgia, Anorexia

  • May lead to:

    • Orchitis, Meningitis, Encephalitis

D/x:

  • Buccal swab

  • IgM serology

T/x: none

  • Rest, Hydration, Analgesics

  • Warm/Cold compress → parotitis

  • Cold compress + elevation → orchitis

  • Soft foods



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Measles (Rubeola)

Transmitted via: (highly contagious)

  • Respiratory, Direct Contact, or AIrbone (2 hours)

  • MMR vaccine

  • 3 Cs (Cough, Coryza, Conjuctivitis) →Koplik spots (red spots w/white centers on buccal mucosa) → Rash (hairline; moves DOWN) → LOW Vitamin A

D/x:

  • IgM

  • PCR

  • Plaque reduction neutralization assay: Gold standard

T/x: supportive

  • Hydration, nutrition, rest

  • fever and infection control

  • Vitamin A for 2 days


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Poliomyelitis

Fecal → oral transmition → replicates in oropharynx & GI → remains in stool for weaks

  • Contact precautions & IPV and OPV vaccines

  • Polio = Paralysis

    • Muscle weakness, paralysis

      • Often in legs

    • May lead to → respiratory failure

D/x:

  • Throat swab, stool, and CSF

  • MRI, EMG

T/x: supportive

  • PT, OT, resp support

  • Nutrition, Hydration


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COVID 19:

Leads to inflammatory immune response → severe → cytokine storm → widespread inflammation

S/s:

  • Fever, Cough, Resp problems

  • Possibly Asymptomatic

  • Multisystem Inflammatory Syndrome:

    • Happens weeks after infection → heart, lyngs, kidneys, gi system issues

  • Possibly lingering s/s:

    • Fatigue, Neuro and Resp issues

D/x:

  • PCR, rapid antigen testing

  • Swab thing

T/x:

  • Remdesivir: blocks its RNA polymerase

    • A/E:

      • Rash, Nauses, Anaphylaxis, v BP

  • Vaccines

  • Airpurification


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Meningitis:

Viral:

  • Enteror, Herpes, Adenovirus

  • Droplet, Hydration

  • S/s:

    • Young:

      • Hypothermia

      • Fever, Irritable, vomiting, difficult to arous

      • Bulging anterior fontanel

    • Old:

      • Fever, Headahche, N/V, Photophobia

      • Nuchal rigidity

      • Diplopia, Irritable, Lethargic

    • Risk for SIADH → hyponateria, seizures, etc.

D/x:

  • Lumbar puncture → CSF

    • WBC, protein, glucose, culture

    • PCR if viral suspected

T/x:

  • Collect specimens → start empiric antibiotics → stop if u find out if it is viral→ IV acyclovir

Bacteria:

  • N. meningitis, Strep. Pneumoniae

  • MORE SEVERE → sepsis, heariling loss, hydrocephalus, death

  • S/s:

    • Fever, hypothermia, Irritable, Vomiting

    • Bulging Fontanel, Kernig & Brudzinski

T/x:

  • Empiric antibiotics, antipyretics, analgesis, hydration

  • Dark, quiet, HOB >30

  • Neutral body alignment


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Meningitis CSF:

Finding

Viral

Bacterial

WBC

>100/mm³

>1,000/mm³

Protein

Normal → mildly elevated

Elevated

Glucose

Normal → mildly low

<40 mg/dL


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Meningitis Precautions:

Droplet precautions

Continue until:

24 hours after IV antibiotics have been administered.

Close Contacts

Certain close contacts may require prophylactic antibiotics.

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Hepatitis:

A:

  • N/V, Diarrhea, Fever, Fatigue

  • Jaundice

  • T/x:

    • Hydration, supportive liver care

    • HAV, sanitation

B:

  • Prodormal phase:

    • Malaise, v appetite, RUQ pain

  • Icteric phase:

    • Jaundice, Yellow sclera, Hepatomegaly, Dark urine

    • Pale stools

  • D/x:

    • HBsAG, IgB testing

  • T/x:

    • Supportive care if Acute

    • Antivital Therapy if Chronic

    • HBV

C:

  • Asymptomatic or malaise + v appetite

  • May lead to chronic infection


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Infectious Mononucleosis:

Epstein Bar virus

  • Saliva Transmission “Kissing disease”

  • 3-6 wks incubation

  • Often occurs in 15-24 yr olds

S/s:

  • Fatigue

  • Pharyngitis

  • Lymphadenopathy

  • Headache, Maialse, Fever

  • Splenegomegaly → Splenic rupture

Edu:

  • Avoid strenuous activities or contact sports

D/x:

  • Monospot antibody testing

  • ^ WBC

T/x: supportive

  • Rest, Hydration, NSAIDs

  • Cool/soft food

  • Salt water gargles

  • Throat lozenges


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Roseola Infantum

from HHV-6 → reproduces in leukocytes and salivary glands → disrupts blood-brain barrier → febrile seizures

  • No current vaccine for it

  • Respiratory droplets + saliva contact

  • Mostly around 6-12 months females

  • Children w/older siblings at higher risk aound spring to fall

S/s:

  • Phase 1: High fever >104/40 for 3-5 days

    • irritable, periorbital edema

    • Otalgia, Anorexia, COugh

    • Cervical Lymphadenopathy

    • DEHYDRATION

  • Phase 2: Rash

    • Rose pink, maculopapular, nonpruritic → neck, face, extremities

    • Fever disappears

T/x: supportive:

  • Hydration, v fever meds, rest, lightweight clothing

  • Avoid overheating, breast milk + E+ solutions

  • May return to normal life after 24 hr fever subsides


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Fifth Disease:

Parvovirus B19; around 5-15 years in spring → early summer

  • Via resp droplets, blood exposure, & direct contact

S/s:

  • Early:

    • Fever, Malaise, Headache, Myalgia, N/V, Diarrhea

    • Most contagious phase

  • Then → slapped cheeck rash → lacy/net like rash]

    • Nonpruritic around trunk and extremities

    • No longer contagious, asymptomatic

  • Arthropathy: common in females

High risk population:

  • Pregnancy, Hemolytic (sickle cell), Immuno compromised

D/x:

  • Parvovirus B19 IgM antibodies

T/x: supportive

  • Rest, Hydration, Fever + Pain management

  • Join pain control


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Hand, Foot & Mouth disease:

Due to human enterovirus + Coxsackie Virus

  • <5 yrs; MOST contagious in first 7 days

  • Fecal oral (diaper changes); resp/oral secretions; direct contact from vesicle fluid; indirect fcontact (fomites)

    • Can remain in poop for 6 weeks → oropharyngeal shedding around 4 weeks (CONTACT PRECAUTIONS)

      • Always maintaine hygiene even after child improves

S/s:

  • Early → low grade fever, sore throat, malaise

  • Painful shallow ulcers

    • Red borders w//white bases → odynophagia and paonful water drinking

  • Hands + Feeet → rashes

    • Also in buttocks, perineum, extremities

  • May lead to: Vital meningitis & encephalitis

D/x: clinical

T/x: supportive care for 7-10 days

  • Fluids, NSAIDS, soft foods, cold nutrition

  • No current vaccine


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Impetigo:

Highly contagious bacterial infection w/honey colored crusts; fibronectin receptors exposes → colonization

  • Staph aureus, Group A strep

  • Around 2-5 years; summer → fall

  • Infants are more likely for bullous impetigo

Nonbullous:

  • Vesicles rupture → honey colored crust

  • Face & mouth; lymphadenopathy

BUllous:

  • Small vesicles merge → large bullae → clear/yellow → purulent & dark

  • Fever + Lymphadenopathy

T/x:

  • Nonbullous → Mupirocin topical; use oral if more systemic s/s or more lesions present

    • Apply 3x/day small amount

    • Before, use soap + water to soften/remove crusts

  • Bullous → oral antibiotics (Cephalexin)

    • Give w/w/out food and shake oral suspension; use accurate measuring device

  • Nonadherence to meds leads to →

    • Rheumatic fever

    • Acute post-strep glomerulonephritis


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Conjuctivitis:

Bacterial:

  • Moraxela, strep. pneumonia, H. Influenza

  • Contact → touches eye

  • S/s:

    • Red sclera, thick purulent drainage, itchy

    • Eyelashes → crust, mat, cant open

  • T/x: supportive for 7-10 days

    • Topical antibiotics (Ciprofloxacin opthalmic)

      • May be temporary burning or stinging or blurry vision = OK!

    • Compresses, sterile saline, avoid rubbing eyes

Viral:

  • Most common; adenovirus/HSV/Enterovirus

  • S/s:

    • REd + watery sclera w/discharge

    • Itching + Tearing

    • Sore throat + Rhinorrhea

    • UPPER RESP INFECTIONS

    • HSV may lead to blindness

  • T/x: supportive

    • Compresses, artificial tears, avoid eye rubbing

    • Acyclovir

Allergic:

  • Pollen, pet dander, air pollution

  • S/s:

    • Intense itching, edness, tearing, eyelid edema

    • Both eyes, NO discharge

  • T/x:

    • v exposure

    • Topical antihistamines + Mast cell stabilizers

      • Epinastine ophtalmic

      • Remove lenese, wait 10 mins before switching them

      • Air purifier, cool compresses, rinse w/water/saline

Foreign-body:

  • Sudden redness, excessive tearing, urge to rub → removal → redness + tearing + v pain → for 24-48 hours

  • T/x:

  • Flush w/sater, saline, fake tears

  • iF chemical: flush


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Stomatitis:

Inflammaito of moral/oral tissues


Herpetic Gingivostomatits:

  • HSV-1

  • DIrect contact w/saliva or lesions; HIGHLY CONTAGIOUS

  • S/s:

    • Painful oral lesions in gums, toungues, inside cheeks

      • Bleeding gums, high fever,

      • Poor nutrition & dehydration

  • D/x:

    • VIral culture of tissue = GOLD STANDARD

  • T/x:

    • Acyclovir w/in 72 hrs of infection

Aphthous Stomatitis:

  • >10 years

  • T-cell immune dysregulation from stress, malnutrition, trauma, genes → v Vitamin D, C & zinc

  • NOT CONTAGIOUS

  • S/s:

    • Painful, flat, round sores in inner lips, cheeks, toungue and floor of mouth

  • T/x:

    • v pain + inflammation

    • Corticostreioids like acetonide (topical)

    • Cool liquids, hydration, soft foods, gentle oral hygiene, saline warm rinses


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Antibody/Immunoglobin:

Y-shaped protein made by B cells

  • Neutralize, Osponize (tag), Activate complement, ADCC

Types:

  • IgM: First one introduced during infection

  • IgG: most abundant in blood stream; important for long term immunity

  • IgA: Bodily secretions; localized protection

  • IgE: Allergic reactions + defense against parasites

  • IgD: Found on B-cell surfaces

M = Made first
G = Greatest amount in blood
A = At secretions
E = Eczema/allergies
D = Development/surface of B cells


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Antigen Types:

Exogenous: outsid eof the body

  • Bacteria, Viruses, Pollen, Food proteins

Autoantigen: from own

  • Autoimmune disease


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Important Immunology Terms:

Antitoxin: neutralizes

  • Botulism, Tetanus, Snake bite uses

  • Immediate passive immunity effect: providing ready antibodies to use

Attenuation: weakening pathogen while making it capable of making a immune response

  • live-vaccines “varicella vaccines”

Cocooning: protecting immunocompromised ppl by immunizing group circle


Innate immunity: immediate nonspecific defense one is born with

  • Skin, Mucous

  • Macrophages, Neutrophils, NK cells

  • INFLAMMATION

Adaptive:

  • B + T lymphocytes


Immunomodulators: meds that modify it

  • Suppress or enhance immune activity

Monoclonal antibodies: Lab produced antibodies

  • For cancer, AI, Infectious disease

T-cell therapy: use of own immune cells + new ones to destroy cancer or pathogens


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Immunization types:

Immunoglobulin Therapy: giving donor antibodies

  • IVIG → IV

  • SCIG → subcut

  • HBIG → IM

  • Provides passive immunity

Toxoids: inactivated toxins to stimulate immune response

  • Diphtheria or Tetanus toxoids


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Vaccines:

Combination vaccines

COnjugate vaccines: polysaccharide antigen attached to carrier protein → stronger response

  • Helps kids develop antibodies

  • Strep. pneumonia, H. influenzae, N. menigitis

Monovalent: one pathogen/strain

Polyvalent: antigens from multiple strains

  • Influenza vaccine


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Haemophilus Influenzae Type B (Hib):

Prevents menigitis AND epiglottits:

Schedule:

  • 2 months → 4 → 6 → 12-15 months final booster

  • IM

    • Vastus lateralis for infants

    • Deltoid for >3 yrs

  • DO NOT GIVE IF <6 weeks

  • A/E:

    • Erythema, Edema, Fever


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Hepatitis A & B Vaccine:

A:

  • 12-23 months → 2nd 6 months later

  • Early travels may have earlier dose but still stick to routine series

B:

  • within 24 hrs of birth → 1-2 months → 6-18 months

    • Low birthweight first is 1 month

  • IM

  • Mild fever


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Polio Vaccine:

IPV: inactivated

  • Injectable

  • 2 → 4 → 6-18 → 4-6 years

    • at least 6 months between doses 3 and 4

  • DO NOT GIVE if bebe has acute febrile illness (^ temp, resp illness)

OPV: oral drops


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Pneumococcal Vaccine:

For strep pneumoniae:

  • Prevents pneumonia, meningitis, sepsis

PCV: pneumoccocal conjugated

  • 2→ 4 → 6 → 12-15

PPSV: pneumoccocal polysaccharide

  • Recommended for higher risk patients

    • Sickle, Asplenia, Immunocompromised

IM

Possible soeness, fever, sleep issues

  • MONITOR 15 mins after due to possible allergic reaction OR syncopy


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Rotavirus Vaccine:

Prevents gastroenteritis, whcich can lead to diarrhea → vomiting → dehydration

  • Live-attenuated + Oral drops

  • 2 → 4 OR 2 → 4 → 6

  • Must be given before 15 weeks; avoid after 8 months

Contradictions:

  • Intussuspetion, SCID, allergies

Possible mild Vomiting or diarrhea


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Varicella Vaccine:

Protects against chickenpox 🐔

  • 12-15 → 4-6 years

  • Live-attenuated

  • Subcut or IM

    • Subcut in triceps or anterolateral thigh

Avoid giving w/pregnancy or poor immunity

POSSIBLE febrile seizure or pneumonia from it

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DTaP vs Tdap:

DTAP: <7 years

  • 2 → 4 → 6 → 15-18 → 4-6 years

Tdap: >7 years

  • 11-12 years → q10 years for boosters

IM

Caution with

  • Guillian Barre syndrome; or severe pain after dose


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MMR vaccine:

Protects against Measles, Mumps, Rubella

  • 12-15 → 4-6 years

  • Live vaccine iven Subcut (triceps)

Avoid if:

  • Pregnancym, poor immune

  • SEVERE allergy to neomycin

May cause febrile seizures

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HPV vaccine:

Prevents warts, cervical/anal/vaginal/penile cancer

  • Start at 9-14 years first dose → 2nd 6-12 months later → 3 doses after → dose 1 is month 0 → 1-2 months after 2nd → 6 months in 3rd

  • IM: deltoid

  • Syncope, Muscle pain, fever may occur


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Meningoccal Vaccine:

Protects against meningitis or bloodstream infection

MenACWY:

  • 11-12 years → booster at 16years

  • If older than 16; only give one dose

MenB:

  • 16-18 years; 2-3 doses

  • More for college students, military recruits, high-risk travelers

IM


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Influenza Vaccine:

Every year beginning at 6 months of age

  • after 9 years → 1 dose qyear

  • <9 years: 2 doses first

LAIV contraindications:

  • Gelatin allegy, v immune, aspirin therapy, wheezing/asthma


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COVID vaccine:

Given at 6 months of age → 2-3 doses

5-11 years: one dose of current vaccine

>12 years: one dose

Annual boosters used

May lead to myocarditis or Pericarditis

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Scabies:

Infection of mites → burrow to skin → lay eggs there → eggs hatch → inflammatory response → INTENSE pruritus

  • Eggs hatch w/in 2-3 weeks

  • Prolonged direct skin to skin contact or via linens/clothing/bedding

S/s:

  • INTENSE night itchin

    • w/in interdigitals, wrists, genitals

  • Tiny linear burrows

  • Possible impettigo or cellulitis

T/x:

  • Permithirin cream → disrupts sodium ion influx in them

    • Avoid placing near eye, nose, ear, mouth, vagina

    • X for <2 months old

  • Cool baths, cold + damp compresses

  • Trim nails


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Perducolis/Lice:

Via close contact or personal things/items/bedding

  • Pruritus, nits, small red bumps

T/x:

  • Premethrin

    • Apply 1 week after too to prevent resistance

  • avoid lindane with children


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Pinworms:

Small-white thread worms that lay eggs in anys

  • Takes 4-8 weeks to mature

S/s:

  • Perianal itching at night

D/x:

  • Tape test: collects eggs w/tape in early morning

t/x:

  • Mebendazole

    • Possible abd pain

  • Bath in morning


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Giardiasis:

Protozoan parasite; fecal-oral

  • entersc → affects intestinal epithelium → malabsorption → watery diarrhea, abd cramps, bloating, gas, fatigue, v weight, deHYDRATION

D/x:

  • Giardia cysts via 3 stool samples

T/x:

  • Metrodinazole

    • Possible Nausea and/or metallic taste and/or flu s/s

  • Sanitation, Boil water

POSSIBLE temporary Dairy intolerance