General Pharmacology: CNS Stimulants

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Flashcards covering key vocabulary and concepts related to CNS stimulants and related topics.

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10 Terms

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Psychomotor Stimulants

Stimulate the CNS, cause excitement and euphoria, elevate mood, increase energy and alertness, and decrease fatigue. Frequently abused and can lead to addiction.

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Hallucinogens

Produce profound changes in perception, thought patterns, and mood. They are drugs of abuse and can lead to addiction.

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Drug Addiction

A complex brain disease characterized by compulsive drug craving, seeking, and use that persists even in the face of extremely negative consequences.

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Brain Reward Pathways

Life-sustaining activities activate this. Addictive drugs also activate it.

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Caffeine

A nonselective antagonist of adenosine receptors, inhibiting adenosine action and thus increasing neural activities. It is used to reduce physical fatigue or drowsiness.

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Nicotine

Binds to nicotinic acetylcholine receptors, resulting in multiple effects, including stimulation of dopamine release in the brain's pleasure circuit, leading to pleasurable sensations and addiction.

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Cocaine

Binds to the transporters of dopamine, serotonin, and norepinephrine (DAT, NET, SERT) and inhibits the reuptake of the monoamines, resulting in a “high” sensation (euphoria).

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Methylphenidate (Ritalin, Concerta)

Inhibits DAT and NET, producing similar stimulating effects as cocaine but with a lower potential for addiction when administered orally as prescribed.

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Amphetamine

Has a similar structure as dopamine and is transported into nerve terminals by DAT, causing leaking of dopamine from synaptic vesicles. It inhibits dopamine uptake and also causes dopamine efflux.

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Tetrahydrocannabinol (THC)

The main psychoactive ingredient in marijuana, which binds to and activates specific cannabinoid receptors, which are G-protein coupled receptors.