Insulin Analoges

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11 Terms

1
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Changes in amino acid on the — chain of insulin will vary it’s duration of action

B

2
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B3 Asp substituted with a Lys and B29 Lys substituted with a Glu

Glulisine

3
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Two Arg groups attached to B30 and A21 Asp substituted with a Gly

Glargine

4
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B28 Pro and B29 Lys swap places

Lispro

5
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B28 Pro substituted for an Asp

Aspart

6
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B30 Thr removed and myristic acid is added to B20 Lys

Detemir

7
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Effect: B3 Asp substituted with a Lys and B29 Lys substituted with a Glu

reduce ability to self associate

8
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Effect: Two Arg groups attached to B30 and A21 Asp substituted with a Gly

allows it to precipitate slowly in body at neutral pH

9
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Effect: B28 Pro and B29 Lys swap places

creates steric hindrance and reduced ability to self associate

10
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Effect: B28 Pro substituted for an Asp

charge repulsion and steric hindrance

11
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Effect: B30 Thr is removed and myristic acid is added to B20 Lys

increase self aggregation