GIT 5.5 - monogastric stomach and abomasum

Name of horse bots

Gasterophilus

Where do Gasterophilus live?

Attach to gastric mucosa of the pars oesophagea in clumps

are Gasterophilus clinically significant?

No

Draschia megastoma

Equine stomach worm

nodules in stomach wall, usually incidental

How pathogenic is Haemonchus contortus (Barber’s pole)

Highly pathogenic

Common signs of haemonchus contortus

die suddenly, exercise intolerance, submandibular oedema

Diarrhoea NOT usually a feature

Pathology of barbers pole

severe anaemia (regenerative and then iron deficiency anaemia), pan hypoproteinaemia

Ostertagia/Teladorsagia disease occurs in

Mostly in young cattle

Ostertagia/Teladorsagia - how many needed to cause clinical disease

Need >10,000 larvae to cause clinical disease

Ostertagia/Teladorsagia - what do they do in the body

Burrow into glands and cause hyperplasia and metaplasia

Interfere with production of HCl which raises pH, leading to diarrhoea and lack of pepsinogen activation which leads to increased pepsinogen in the blood

Ostertagia and Teladorsagia

What does hyperplasia and metaplasia cause?

increased pepsinogen in the blood

hypoalbuminaea and oedema (loss of albumin into abomasum)

Type I Ostertagiasis

ingestion of high numbers over a short time

Type II Ostertagiasis

mass emergence in late winter or spring

Most reliable ClinPath sign of ostertagia/telodorsagia diagnosis

increased pepsinogen in the blood

Why does ostertagia/telodorsagia cause increased pepsinogen in the blood?

Hyperplasia/metaplasia interferes with HCl production

Pepsinogen builds up as it needs acidic conditions to make pepsin