- no striation - uninucleated - nucleus centrally located
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skeletal muscle
- striated - multinucleated - nucleus peripherally located
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cardiac muscle
- striated - uninucleated or binucleated - nucleus centrally located
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epimysium
surround the muscle group
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perimysium
surrounds fasicle
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endomysium
surrounds muscle fiber/cell
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sarcomere
functional unit of muscle
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striation
comes from arrangement of myofilaments within myofiber
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myofilament
actin and myosin
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myofiber
muscle cell
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I-band
actin only; light region of sarcomere
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A-band
myosin plus overlapping actin; dark region of sarcomere
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H-band
myosin only; center of A-band
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M-line
center of A band
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thick filaments
myosin
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thin filaments
actin
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z-line
how sarcomeres are divided from each other, found in center of I band
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sarcolemma
muscle plasma membrane
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T tubules
extension of sarcolemma into muscle fiber; carry action potential to interior myofibrils
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Sarcoplasmic reticulum
stores calcium ions
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excitation-contraction coupling
pairs depolarization of neuron with depolarization of a muscle cell
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steps of excitation-contraction coupling
- Ach is released into neuromuscular junction and binds to receptor site on sarcolemma - action potential travels down T tubules causing Ca2+ channels to open - intracellular Ca2+ concentration increases - Ca2+ binds to troponin on thin filaments - Tropomyosin moves away to allow myosin to attach to actin - cross-bridge cycling begins and force is generated - Ca2+ is reaccumulated by SR and muscle relaxes
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Ca2+ is low
tropomyosin blocks myosin binding site on actin; no contraction
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Ca2+ is present
Ca2+ binds to troponin complex which changes tropomyosin to allow myosin to bind to actin; contraction can occur
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sliding filament theory
- ATP binds to myosin and causes myosin head to detach - ATP hydrolyzed into ADP and P; myosin is in resting cocked position - myosin binds to actin monomer forming crossbridge - P is released; filaments slide past each other (powerstroke) - ADP is released
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motor unit
single motor neuron and the muscle fibers it innervates
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small motor units
fine motor activities
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large motor units
gross motor activities
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recruitment
start using small motor units and add more as needed
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isometric action
muscle contract and length remains; force generated is insufficient to overcome load
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isotonic action
contraction tension remains constant and muscle changes length and moves the load
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concentric action
muscle contracts and shortens
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eccentric action
muscle contracts and lengthens
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agonist
primary mover
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synergist
muscle that assist agonist group
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antagonist
muscles that oppose the agonist
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Slow Twitch - Type I
- mostly aerobic respiration, not large amount of force, fatigue resistant, efficient, lots of mitochondria - endurance athlete
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Fast Twitch - Type IIX
- anaerobic glycolysis or direct phosphorylation of ADP - less resistant to fatigue, high power output, rich in glycolytic enzymes, small number of mitochondria - 100m sprint
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Fast Twitch - Type IIA
- intermediate fibers, mix of Type I and Type IIX - 800m sprint
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hypertrophy
increase in muscle fiber diameter due to increase in myofibril size; muscle can exert more force due to proportionality of cross-sectional area and force
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Muscle soreness
- from microscopic injury to muscle fibers - 24-48 hrs after injury - not from lactic acid accumulation
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Rigor mortis
postmortem muscle stiffness due to rigor cross-bridges in absence of ATP
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Sarcopenia
age related decline in muscle mass beginning around age 25 and occurs across lifespan
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slow phase sarcopenia
10% muscle mass loss from age 25-50
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rapid phase sarcopenia
additional 40% muscle mass loss from age 50-80
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Muscular dystrophy
- group of hereditary muscle diseases that weaken skeletal muscle - no cure and respiratory failure usually occurs early in life - lack dystrophin protein