PHOSPHORUS

Phosphorus

Is the major anion in the intracellular fluid which is inversely related to calcium

bones, teeth

intracellular fluid

Phosphorus

Distributed as 85% in _ and _, 15% in _ _

neuromuscular activity

ATP- ADP, vitamin B

carbohydrates, proteins, fats

Functions

Role in _ _

Durability of bones and teeth – helps in the formation of _-_, _ _ utilization, transmission of hereditary traits

Metabolism of _, _, and _ and in the acid-base balance

kidneys

GI secretions

Excretions

Majority of this electrolyte is being excreted by body through the _ (90%) and only 10% by the _ _

Parathyroid Hormone

Regulation

Lowers Phosphate concentration by increasing renal excretion

Vitamin D

Regulation

Increases Phosphate concentration by reabsorption in the kidney

Growth Hormone

Regulation

Increases Phosphate concentration by regulation of skeletal growth

Alcohol abuse - most common

Vitamin D deficiency

Hyperthyroidism

Hypophosphatemia (3)

Renal failure

Increased phosphate intake

Increased cellular phosphate release

Increased breakdown of cells

Hyperphosphatemia (4)

Serum

Plasma (lithium heparin)

24 hour urine

Specimens (3)

Oxalate, citrate, EDTA

false increased

Interferences

Do not use _, _, _ which tends to falsely decrease the level of phosphorus

Do not use hemolyzed specimen that gives _ _ result

Fiske-Subbarow Method

Methods of Measurement

Conversion of inorganic phosphate to heteromolybdenum blue by reacting with ammonium molybdate

5-Minute Test Micro Method

Methods of Measurement

Second method

600

Mix well and read at _ nm against water blank after five minutes

5

Computation factor (mg/dL)

0.324 = mmol/L

Conversion to SI unit (mmol/L) for phosphorus levels.

2.5-4.5 mg/dL

Normal Range

Conventional Unit

Adult

0.81-1.46 mmol/L

Normal Range

SI Unit

Adult

3.5-6.5 mg/dL

Normal Range

Conventional Unit

Infant & Children

1.13-2.11 mmol/L

Normal Range

SI Unit

Infant & Children

Photometric UV test

Method in lab manual