Inflammation, Tissue Repair, and Wound Healing

Flashcards on Inflammation, Tissue Repair, and Wound Healing

Inflammation is defined as a __.

Reaction of vascularized tissues to injury, characterized by inflammatory mediators and movement of fluid.

__ inflammation is of relatively short duration and characterized by exudation of fluid and emigration of neutrophils.

Acute

__ inflammation lasts for days to years and is associated with lymphocytes, macrophages, and fibrosis.

Chronic

The five cardinal signs of inflammation are __, __, __, __, and __.

Pain, Heat, Redness, Swelling, and Loss of Function

The __ recognizes antigens and attempts to destroy them.

Immune response

Common causes of Inflammation include __.

Immune response to infectious organisms, trauma, surgery, caustic chemicals, extremes of heat/cold, and ischemic damage.

During inflammation, __ results in increased blood flow, causing redness and heat.

Vasodilation

__ are delivered to the area of injury for clean up via phagocytosis during the cellular stage of acute inflammation.

Leukocytes

__ are the primary phagocytes that arrive early at the site of inflammation.

Neutrophils

__ are communication molecules that use adhesion molecules to stick to the endothelium.

Cytokines

__ is one of the first mediators released during an acute inflammatory reaction.

Histamine

__ inflammation is a type of chronic inflammation characterized by the formation of granulomas.

Granulomatous

__ exudates are watery fluids low in protein content.

Serous

__ exudates contain pus and are composed of degraded white blood cells and tissue debris.

Purulent

__ inflammation is of relatively short duration and is aimed at removing the injurious agent.

Acute

__ inflammation is of longer duration and can be a recurrent or progressive acute process.

Chronic

Acute Inflammation primarily involves infiltration of & .

Neutrophils & Exudate

Chronic Inflammation sees infiltration by __, __, and proliferation of __.

Macrophages, lymphocytes, and fibroblasts

Systemic manifestations of inflammation include alterations in white blood cell count, otherwise known as or , as well as and elevated

Leukocytosis or leukopenia, fever, elevated CRP/ESR

__ tissues contain the functioning cells of an organ.

Parenchymal

__ cells continue to divide and replicate throughout life, such as skin cells.

Labile

__ cells normally stop dividing when growth ceases, but can divide when needed, like liver cells.

Stable

__ cells cannot undergo mitotic division, such as neurons.

Permanent

__ healing involves small, clean wounds closed with suture material.

Primary

__ healing involves great loss of tissue with contamination, healing naturally from the bottom up.

Secondary

During the inflammatory phase of wound healing, __ are the first cells to arrive, ingesting and removing bacteria.

Neutrophils

During the proliferative phase of wound healing, __ synthesize and secrete collagen.

Fibroblasts

Factors that can impair wound healing include __.

Malnutrition, impaired blood flow, impaired immune response, infection, wound separation, foreign bodies, and age effects