BIOC100B: Protein Structure

What are conformations?

Structure states possible that don’t involve breaking bonds;

• Certain configurations exist in biological setting

• Usually the lowest delta G energy state

“Native” protein?

Protein configurations are those who are functional

ΔG of a protein and the forces affecting folding

• ~5 - 65 kj/mol

• High Entropy and HB with water leans to an unfolded state

• Hydrophobic effect and other forces leans to an folded state

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