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osteoclasts
bone destroying cells; help dissolve minerals (Ca, P); found on bone surface and leave small cavities
osteoblasts
bone forming cells; found on the surface of bone just below periosteum, fill cavities made by osteoclasts, triggered by estrogen and testosterone and decrease loss of bone
compact bone
forms the hard outer shell of a bone; consists of tightly packed cylinder shaped osteons; provides protection and support
osteons
have haversian canals which contain blood vessels and nerves
spongy bone (cancellous)
lighter less dense; consists of thin lattice (taburculae) arranged to provide maximum support; cavities filled with red marrow
long bones
longer than wide (femur)
short bones
small cube shape (tarsals, carpals)
flat bones
broad flat surface (sternum, scapula)
irregular bones
odd shaped ( vertebrae)
red bone marrow
makes red and white blood cells (hemopoesis)
*erythropoiesis = RBCs
*leukopoiesis = WBCs
yellow bone marrow
fat; most bone marrow converts to this as you age but can switch back in an emergency (flat bones make marrow throughout life)
metaphysis
contain the growth portion of the bone
*location of epiphyseal line/plate depending on age
ossification (osteogenesis)
process of bone development by osteoblast
*intermembranous - from membranes
*endochondral - from cartilage
joints
where bones come together
*except hyoid
synovial joints
joined indirectly by associating ligaments and a fibrous sealed capsule; contains synovial fluid; most common & mobile
*articulating surface covered in hyaline cartilage
*double layered capsule- fibrous strong outer, smooth innner that produces synovial fluid
menisci
fibrocartilage discs that help the joint move smoothly and absorbs shock
gliding joint
intercarpal/tarsal joints, AC/SC joints, vertebrocostal joints
hinge joint
elbow, knee, ankle, interphalangeal
pivot joint
atlas/axis, Prox radioulnar
ellipsoid joint
radiocarpal joint,
saddle joint
1st CMC joint
ball-and-socket joint
hip, shoulder
anatomy
study of structures of the human body and their positional relationship to one another
physiology
study of how the body and its structures parts function in normal body processes
cellular organization
provide functions that are vital to life and consist of muscle, bone, nervous cells
tissue organization
group of cells that have similar structure and perform specific functions
*epithelial, connective, muscular, nervous
organ organization
composed of complex structures containing two or more types of tissues that perform specialized functions
organ system
group of related organs with complementary functions that arrange themselves into systems
organism
represents a living entity
cells
smallest structural and functional unit that can exist as a self-sustaining entity and are the building blocks of the human body
Cell membrane (plasma membrane)
the "gatekeeper," membrane separating intracellular fluid from extracellular fluid; semi-permeable allowing for exchange of nutrients and waste
Cytoplasm (protoplasm)
gel-like intracellular fluid; location where most cellular activities such as metabolism and cell division occurs; provides cellular nutrition and supports organelles; portion not within organelle is called cytosol, portion within organelles is endoplasm
Endoplasmic reticulum (ER)
" cellular roadway;" network of curved sacs arranged in parallel rows found near the center of the cell; pieces of the ER break off and become parts of other organelles or the cell membrane unique to this organelle
Rough ER
spotted w/ ribosomes, synthesizes protein
Smooth ER
no ribosomes, synthesizes lipids, metabolizes carbs and steroids, & regulates calcium concentration
Ribosomes
small granules of ribonucleic acid (RNA) some floating freely in the cytoplasm, "protein factory" for use in and outside of the cell
• Golgi body
series of separate horizontal membranous sacs that are stacked on top of each other, "packing and shipping" of synthesized lipids and proteins that are stored or shipped wrapped in a piece of the golgi body for intra or extra cellular use
• Mitochondria
"power plant;" oval organelles that look like partitioned sausages, two membranes: outer= flat and smooth, inner= folded numerous chambers called cristae; produces most of the cells energy (ATP)
• Lysosomes
membranous organelles that have broken off from golgi bodies, size depends on activity level- small when inactive, large with active, they are the "garbage disposals" breaking down proteins that are not needed as well as engulf and destroy pathogens by using digestive enzymes, also release enzymes at injury sites to remove cellular debris
• Centrioles
paired, tubular structures that help cells to divide, cells that do not have centrioles cannot divide such as mature RBCs, nerve, and muscle cells
• Nucleus
spherical shaped and often the largest organelle of the cell, contains clusters of DNA and RNA
o Passive (passive transport)
do not require energy or activity of the cell membrane; molecules move due to pressure, concentration, and temperature gradients, movements are dynamic and continue even after equilibrium is met
Diffusion- movement of molecules from high concentration to low
Diffusion
- movement of molecules from high concentration to low concentration
Osmosis
movement of water across a cell membrane from an area of low concentration to high concentration to equalize the fluid concentration on both sides of the membrane
Filtration
movement of water and molecules across a cell membrane due to pressure such as in the kidneys
Active (active transport)
require the cell to expend energy to help move the molecules across its membrane, this is for molecules that must move up the concentration gradient "uphill"
endocytosis
moves substances inside cell
phagosytosis
cell eating
pinosytosis
cell drinking
exocytosis
moves substances outside the cell, important in neurotransmission
Metabolism
the sum total of all physical and chemical processes that occur in a organism
Anabolism
constructive metabolism in which simple small molecules are made into larger more complex ones
Catabolism
destructive metabolism in which larger more complex molecules are broken down in to smaller simpler ones
Epithelial
covers internal and external structures such as skin and blood vessels and lines open and closed body cavities
Muscle
located in hollow internal organs and tubes and is attached to bone, functions for movement, posture, and heat
Connective
forms framework for organs and glands and for the body as a whole
Nervous
- located in the brain, spinal cord, and nerves interprets sensory information and coordinates bodily processes
Homeostasis
the tendency of the body's internal environment to remain relatively constant with a narrow range of change
muscle functions
movement, posture, heat
muscle excitation
responsive to stimuli
muscle contraction
force generation
muscle extensibility
extend/ lengthen during force
muscle elasticity
returns to original length
sarcolemma
covering of muscle fiber, contains motor end plate
sarcoplasm
inter-cellular fluid
sarcoplasmic reticulum
system of interconnected hollow tubules (t-tubules) that play a crucial role in storing and releasing Ca ions
myofibrils
each muscle contains thousands of slender strands that run the length of each muscle fiber, each contains sarcomeres
sarcomere
basic unit of contraction, length from Z line to Z line contains myofilaments
myofilaments
thin- actin
thick- myosin
*striations
hypothalamus
gland in the bring that is the control center for all regulatory activities of the body
blood
8% of total body weight, 5L total volume in aver age adult, single blood cell makes a round trip in 60s, 55% liquid plasma and 45% blood cells
thrombocytes
platelets
erythrocytes
red blood cells (most numerous type); loose nucleus and other organelles as they emerge from bone marrow and enter bloodstream , lifespan of 105-120 days, hemoglobin gives characteristic red color
leukocytes
white blood cells, granular- neutrophils, eosinophils, basophils, agranular- monocytes and lymphocytes
AV valves (cuspid)
located between atria and ventricles
SL valves
located between ventricles and the aorta or pulmonary trunk
tricuspid valve (R-AV)
located between right atrium and right ventricle
bicuspid (mitral) valve
left AV valve located between left atrium and left ventricle
diastole
ventricles relax and fill
systole
ventricles contract and eject blood