Ligand binding

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4 Terms

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What are ligands

Small molecules to proteins, what ever is binds onto the other things

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Ligand binding

  • non-covalent

  • At binding site, complementary (h-bonds, ion interaction, hydrophobic, van der waals, shape and size, his tag-nickel)

  • Can be cooperative (sigmoidal, allostery), non-cooperative (hyperbolic)

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Ka vs Kd

Association vs dissociation

Kd is just reciprocal of Ka and less ambiguous

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Kd

Ligand binding will approach 1

Kd is unit of concentration of ligand needed for half of the protein to be bound

Reflects affinity- reverse relationship (low Kd means strong binding)