PC 2 mod 2.2 lec 10 (aminoglycoside med chem)

- protein synthesis

- 30S

MOA of aminoglycoside is by inhibition of ______ by binding _____, but also other mechanism

yes

can AG be bacteriostatic

aminoglycoside

example of

2 N

in core of aminoglycosides, there are two ____ on ring

- aminoglycoside acetyltransferases (AACs)

- aminoglycoside phosphotransferases (APHs)

- aminoglycoside nucleotidyltransferases (ANTs)

3 aminoglycoside modifying enzymes that cause resistance

- amine

- alcohol

- nucelophilic

_____ and ______ of aminoglycosides have lone pairs of electrons, giving them ______ character to cause resistance

NH2 and OH

acylation of AG occurs on _____ and _____

OH

adenation of AG occurs on _____

OH

phospohorylation of AG occurs on ______

- hydrogen bonds

- bacterial ribosomes

enzymes inactivate aminoglycosides by disrupting ________ and affinity to ______

no, innactivate each other

can gentamicin and amoxicillin be given together in the same solution?

administer into different tissue compartments

how could you administer gentamicin and a beta-lactam together?

gentamicin and beta lactam (amoxicillin)

______ and ______ cause each other to become inactivated if given in the same solution

AAC (acetyltransferase)

APH (phophotransferase)

ANT (nucleotidytransferase)

______ act on OH and NH2

______ act on OH

______ act on OH