lec 19/20: cancer stem cells

describe the heterogeneity of tumours and how cancer stem cells were discovered

what is the CSC hypothesis and how was this formed?

at what levels of cell hierarchy can a mutagenic event happen?

what are the 3 potential sources of heterogeneity in CSCs?

1. Hierarchy (CSC, progenitor)

2. location

3. temporal/time

describe the two types of medulloblastoma

describe the temporal differences in acute myeloid leukemia development

are CSC resistant to chemotherapy?

what are the 4 mechanisms CSCs have for resisting chemo

how are SC properties acquired?

describe asymmetric division in drosophila neuroblast

describe the function of Numb and Musashi

what is the function of Wnt signaling in the cell

describe the Wnt pathway and how is is dysfunctional in CA

what is the function of Notch signaling in the cell and what happens when it is abnormal

describe the Notch signaling pathway

what is the function of Sonic Hedgehog signaling in the cell and what happens when it is abnormal

describe the SHH pathway

generally how is the niche involved in cancer stem cell plasticity

• CSCs can depend on a niche like other SC, although this may be distinct from normal SCs and may be formed through a reciprocal interaction between CSC and its environment

describe the relationship between glioblastoma SCs and endothelial cells

describe the relationship between myofibroblasts and CSC

what are some uses of CSC in cancer therapy