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what are the 3 steps to bone development?
growth, modeling, remodeling
what are osteoclasts?
cell that erode bone, aka resorption
what are osteoblasts?
cells that lay down a collagen matrix, aka builds bone
what is the bone composition?
65% of tissue is minerals like calcium and phosphorus, 35% is organic substances like collagen
what is collagen?
protein that provides structure in the bones and connective tissue
what is used to measure bone density?
DEXA
what is osteoporosis?
condition where bones become weak and brittle
what are parathyroid hormone and calcitonin?
hormones that regulates blood calcium levels
what is the function of vitamin C?
produce collagen
what is the RDA for collagen?
90 mg/day for men, 75 mg/day for women, smokers need RDA+35
what are good food sources of vitamin C?
fruits and veggies
what condition is caused by vitamin C deficiency?
Scurvy, lack of collagen makes bones and tissue weak or destroyed
what are the symptoms of toxicity from vitamin C supplements?
nausea, diarrhea, nosebleeds
what is the function of calcium?
supports bone health and structure, 99% of calcium in the body is stored in the hydroxyapatite crystals in bones
what is the RDA for calcium?
1000 mg/day for adults, 1200 mg/day for women 51+ and men 70+
what are good food sources of calcium?
dairy, green leafy veggies, tofu, sardines
what conditions are caused by calcium deficiency?
osteoporosis and hypocalcemia
what are the symptoms of toxicity from calcium supplements?
mineral imbalance
what is the function of phosphorus?
combines and crystalizes with calcium in bones to form hydroxyapatite crystals
what is the RDA for phosphorus?
700 mg/day
what are good food sources of phosphorus?
high protein foods like milk, meat, eggs
what does phosphorus toxicity risk?
premature morality from high intake, muscle spasms and convulsions from high blood levels
what is the function of magnesium?
regulates calcium balance, vitamin D metabolism, and parathyroid hormone
what is caused by magnesium deficiency in blood?
hypomagnesemia
what is caused by magnesium toxicity in blood?
hypermagnesemia
what is the function of fluoride?
strengthen teeth and bones
what is caused by fluoride deficiency?
tooth decay
what is caused by fluoride toxicity?
pitting and staining of teeth
what is the function of vitamin D?
needed for absorption and normal calcification of bone, regulates calcium
what is caused by vitamin D deficiency in children?
Rickets, causes bowed legs and knocked knees
what is caused by vitamin D deficiency in adults?
Osteomalacia, bones are weak and prone to fracture