Gluconeogenesis (GNG)

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L22

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5 Terms

1
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How does metabolism change under starvation conditions?

PFK-1 will be stimulated to make energy via glycolysis

2
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what happens during anaerobic metabolism?

  • limited O2 → ETC inhibited

  • oxidative phosphorylation (ETC & ATP synthase) inhibited, PDC & TAC slows down

  • glycolysis becomes the only way to generate ATP

  • lactate dehydrogenase convert NADH back to NAD+ → allow glycolysis to continue

  • pyruvate reduced to form lactate

<ul><li><p>limited O<sub>2</sub> → ETC inhibited</p></li><li><p><strong>oxidative phosphorylation</strong> (ETC &amp; ATP synthase) <strong>inhibited</strong>, PDC &amp; TAC slows down</p></li><li><p><u>glycolysis</u> becomes the <u>only way to generate ATP</u></p></li><li><p><strong>lactate dehydrogenase</strong> <u>convert NADH back to NAD<sup>+</sup></u> → allow glycolysis to continue</p></li><li><p>pyruvate reduced to form lactate</p></li></ul><p></p>
3
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how does pyruvate & lactate transform to each other?

pyruvate reduces to lactate via NADH → NAD+ by lactate dehydrogenase

4
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What’s the Cori Cycle

  • recycle of lactate to produce glucose in liver, then sent back to muscle

  1. Lactate converted back to pyruvate

  2. generate glucose

  3. export glucose, to be used by other cells

→ GNG

<ul><li><p>recycle of lactate to produce glucose in liver, then sent back to muscle</p></li></ul><ol><li><p>Lactate converted back to pyruvate</p></li><li><p>generate glucose</p></li><li><p>export glucose, to be used by other cells</p></li></ol><p>→ GNG</p><p></p>
5
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2 glycerol molecules are used to make a 6C glucose, entering the pathway as ____

DHAP