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Vocabulary flashcards covering key terms and definitions related to the cytoplasm, organelles, endomembrane system, cytoskeleton, and nucleus as described in the lecture notes.
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Cytoplasm
All cellular material between the plasma membrane and the nucleus, comprising cytosol, inclusions, and organelles.
Cytosol
Gel-like solution of water and soluble molecules (proteins, salts, sugars) in which cellular components are suspended.
Inclusions
Insoluble molecules in the cytoplasm that vary by cell type (e.g., glycogen granules, pigments, lipid droplets, vacuoles, crystals).
Organelles
Membrane-bound or nonmembrane-bound structures that perform specific cellular functions.
Membranous organelles
Organelles enclosed by membranes, such as mitochondria, ER, Golgi, peroxisomes, and lysosomes.
Nonmembranous organelles
Organelles not enclosed by a membrane, such as ribosomes, cytoskeleton, and centrioles.
Mitochondria
Organelle that produces most of the cell’s ATP via aerobic respiration; has double membranes and cristae.
ATP
Adenosine triphosphate; the cell’s main energy currency.
Cristae
Folded inner membrane folds of mitochondria that increase surface area for energy production.
Mitochondrial DNA (mtDNA), RNA, and ribosomes
Genetic material and ribosomes contained within mitochondria used for mitochondrial protein synthesis.
Ribosomes
Nonmembranous organelles where protein synthesis occurs; made of protein and rRNA.
Free ribosomes
Ribosomes floating freely in cytosol; synthesize soluble cytosolic or organelle proteins.
Membrane-bound ribosomes
Ribosomes attached to the rough ER; synthesize proteins for membranes, lysosomes, or export.
Endoplasmic Reticulum (ER)
Network of parallel, cisterns continuous with the outer nuclear membrane; two forms: rough and smooth.
Rough ER
ER with external ribosomes; synthesizes secreted and membrane proteins; proteins are modified and packaged for Golgi.
Smooth ER
ER without ribosomes; functions include lipid metabolism, detoxification, glycogen-to-glucose conversion, and calcium storage.
Saroplasmic reticulum
Specialized smooth ER in skeletal and cardiac muscle cells involved in calcium storage and release.
Golgi apparatus
Stacked cisternae that modify, concentrate, and package proteins and lipids from the rough ER; acts as traffic director.
Transport vesicles
Vesicles that fuse with the Golgi’s cis face to deliver proteins and lipids for processing.
Peroxisomes
Membranous sacs that detoxify toxins and break down fatty acids; contain oxidases and catalase.
Oxidases
Enzymes in peroxisomes that convert toxins to hydrogen peroxide (H2O2).
Catalase
Enzyme in peroxisomes that breaks down H2O2 into water and oxygen.
Lysosomes
Spherical vesicles with acid hydrolases that digest bacteria, viruses, toxins, and old organelles.
Acid hydrolases
Digestive enzymes inside lysosomes that break down biomolecules.
Autolysis
Self-digestion of a cell when lysosomal enzymes are released intracellularly due to injury.
Endomembrane system
Interconnected membranous organelles (ER, Golgi, secretory vesicles, lysosomes) plus nuclear and plasma membranes that build, degrade, store, and export molecules.
Cytoskeleton
Network of protein filaments giving the cell its shape, support, and ability to move components.
Microfilaments
Thin actin filaments that support the cell’s shape and aid in movement.
Intermediate filaments
Mid-thickness filaments providing tensile strength and anchor points for organelles.
Microtubules
Hollow tubes that act as tracks for movement and form the mitotic spindle.
Centrosome
Microtubule-organizing center near the nucleus; contains a matrix and centrioles.
Centrioles
Paired, barrel-shaped organelles at right angles; form the basis of cilia and flagella.
Cilia
Whiplike, motile extensions that move substances across cell surfaces in one direction.
Flagella
Longer extensions that propel whole cells, such as sperm tails.
Basal bodies
Organize the formation of cilia and flagella at their bases.
Microvilli
Fingerlike projections that increase surface area for absorption; contain actin filaments.
Nucleus
Largest organelle containing the cell’s genetic library; oversees protein synthesis.
Nuclear envelope
Double-membrane barrier enclosing the nucleus; outer layer continuous with rough ER.
Nucleolus
Dense region within the nucleus where rRNA is synthesized and ribosome subunits assemble.
Chromatin
DNA-histone-RNA complex; condenses into chromosomes during cell division.
Chromosomes
Condensed chromatin visible during cell division; carries genetic information.
Nucleolar organizer regions (NORs)
DNA regions that code for rRNA and organize nucleolus formation.
Nuclear pores
Openings in the nuclear envelope that regulate transport; guarded by the nuclear pore complex.
Nuclear pore complex
Protein assemblies that regulate movement of large molecules into and out of the nucleus.
Nucleoplasm
Fluid inside the nuclear envelope surrounding the chromatin and nucleolus.
Anucleate
Having no nucleus; e.g., mature red blood cells.
Multinucleate
Cells with more than one nucleus, such as some skeletal muscle and liver cells.
Glycogenolysis
Conversion of glycogen to free glucose, a key energy-releasing process in Smooth ER.
Detoxification (in ER and peroxisomes)
Metabolic processes that neutralize or remove toxic substances from the cell.
Lipid metabolism
Processes of lipid synthesis, storage, and transport primarily by Smooth ER and related organelles.