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parts of a neuron
nucleolus, nucleus, cell body, dendrites, axon, nodes of Ranvier, myelin sheath, axon terminal
structural classifications of neurons
multipolar, one axon, many dendrites; bipolar, one axon, one dendrite; unipolar, only axon, no dendrites
functional classifications of neurons
sensory/afferent, signals from skin and visceral organs; interneuron/association, carry messages between neurons; motor/efferent, signals to muscles and glands
what speeds up a nerve impulse?
more myelin, thicker diameter of axon
neuroglial cells and functions in CNS
astrocytes, support and anchor neurons to capillaries, control environment around neurons; ependymal cells, line central cavity of CNS, form barrier between CSF and brain; oligodendrocytes, make myelin sheath; microglial cells, perform phagocytosis, monitor health
neuroglial cells and functions in PNS
satellite cells, control environment around neurons; Schwann cells, make myelin sheath
3 types of nerve fibers
group A, somatic/motor, skin, skeletal muscle, joints, myelinated, 150 m/s; group B, ANS, lightly myelinated, 15 m/s; group C, sensory, skin, visceral, unmyelinated, 1 m/s
events of neuron synapse
action potential arrives at axon terminal, calcium channels open, synaptic vesicles release neurotransmitters, neurotransmitters diffuse across synaptic cleft and binds to receptors, opens ion channels, causes graded potential, neurotransmitters destroyed from synaptic cleft
what is an IPSP?
inhibitory postsynaptic potential; causes hyperpolarization of postsynaptic membrane
what is an EPSP?
excitatory postsynaptic potential; causes depolarization of postsynaptic membrane
sequence of action potential
resting potential, reaches threshold, depolarization, repolarization, hyperpolarization, resting potential
no summation
type of graded potential; multiple EPSPs separated by time; no action potential
temporal summation
type of graded potential; multiple EPSPs in rapid sequence; action potential
spatial summation
type of graded potential; multiple EPSPs from different locations at same time; action potential
spatial summation of EPSPs & IPSPs
type of graded potential; both occur at same time and cancel each other out; no action potential
what are neurotransmitters?
neurotransmitters create graded potentials
serotonin
neurotransmitter; mood regulation, hunger, sleep, anger control, sexual desire; too little causes depression, OCD, chronic fatigue
dopamine
neurotransmitter; motor movement, alertness, good feelings, aggression, thinking, planning; too much causes Parkinson’s; too little causes schizophrenia, lack of remorse and affection
endorphins
neurotransmitter; pain control, stress reduction, pleasure; too little causes low pain tolerance, depression, sleep issues
acetylcholine (Ach)
neurotransmitter; motor movement, learning and memory, deep sleep; too little causes Alzheimer’s, dementia, muscle disorders
GABA (gamma-aminobutyric acid)
inhibitory neurotransmitter; reduces anxiety and insomnia, inhibits CNS/muscle tone; too little causes seizures, epilepsy, insomnia, anxiety, depression, mood disorders
norepinephrine
neurotransmitter; fight or flight response, alertness, increased heart rate; too much causes depression, racing heart, manic; too little causes lack of drive, less focus on goals
adenosine
inhibitory neurotransmitter; promotes sleep by suppressing alertness; too little causes restless leg syndrome
glutamate
neurotransmitter; major excitatory actions in brain, learning, memory; too much causes Alzheimer’s; too little causes seizures
how can drugs affect the neuromuscular junction?
drugs can either block or enhance events at the neuromuscular junction
prosencephalon (forebrain)
cerebrum, lateral ventricles, diencephalon, retina, third ventricle
mesencephalon (midbrain)
midbrain and cerebral aqueduct
rhombencephalon (hindbrain)
pons, cerebellum, medulla oblongata, fourth ventricle
sulcus (pl. sulci)
shallow dip
gyrus (pl. gyri)
elevated ridge
fissure
deep groove
function of cerebrospinal fluid (CSF)
cushions and reduces weight of brain
locations of CSF
ventricles and subarachnoid space
what is the blood brain barrier?
tight junctions between capillary endothelial cells keep brain homeostasis
what can pass through the blood brain barrier?
lipid-soluble molecules
reflex arc
receptor, sensory neuron, integration center, motor neuron, effector
mechanoreceptors
touch, pressure, pain, proprioception, vibrations
thermoreceptors
temperature
chemoreceptors
chemicals
photoreceptors
light
nociceptors
pain/inflammation
exteroreceptors
at/near body surface
interoreceptors
inside body
sympathetic nervous system
fight or flight; dilate pupil, reduce saliva, peripheral blood vessels constrict, vasodilate bronchioles, increase heart rate, slow stomach secretions and peristalsis, no insulin produced, increased production of epinephrine and norepinephrine, decrease urine production, ejaculation, relax uterus
parasympathetic nervous system
rest and digest; pupil constricts/focuses, increase lacrimal gland functions, increase saliva, lower heart rate, bronchioles constrict, produce insulin, increase digestion, increase urine production, arousal, contract uterus
cholinergic receptors
use Ach; nicotinic, postganglionic neurons, adrenal medullary cells; muscarinic, parasympathetic target organs
adrenergic receptors
use norepinephrine and epinephrine; heart, sympathetic target organs, adipose tissue
types of papilla on tongue
fungiform, foliate, circumvalate papillae have taste buds; filiform papillae have pain and touch receptors
gustatory path to brain
microvilli, taste pore, gustatory receptor cell, sensory neuron, solitary nucleus, thalamus, gustatory complex
parts of ear involved in hearing
external auditory meatus, tympanic membrane, malleus, incus, stapes, oval window, cochlea
parts of ear involved in balance
utricle, saccule, semicircular canals
hearing path to brain
sound goes through ear parts, vestibulocochlear nerve, thalamus and/or inferior colliculi, primary auditory complex
olfactory path to brain
cilia, dendrites, axon, glomerulus and mitral and tufted cells in olfactory bulb, thalamus, hippocampus and amygdala, temporal lobe
vision path to brain
cornea, anterior chamber, iris, pupil, lens, vitreous chamber, retina, optic nerve, thalamus and/or superior colliculi, primary visual cortex