what happens when X rays hit you or your patient?

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recap - what are X rays?

  • X rays are a type of electromagnetic radiation 

  • they are an ionising radiation source 

  • they are at the higher end of the EM spec 

<ul><li><p>X rays are a type of electromagnetic radiation&nbsp;</p></li><li><p>they are an <strong>ionising </strong>radiation source&nbsp;</p></li><li><p>they are at the higher end of the EM spec&nbsp;</p></li></ul><p></p>
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interaction of X rays with matter

knowt flashcard image
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there are two types of interactions that can occur at the atomic level - what are they?

  1. photoelectric effect 

  2. Compton scatter 

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photoelectric effect

  • this is the effect that gives us contrast in our final images 

  • the electrons that are furthest from the nucleus have the weakest attraction 

  • the photoelectric effect is what happens when an X ray interacts with in inner shell electron 

  • X ray will come into the atom, interact with an inner shell electron 

  • because the electron is highly attracted to the nucleus, it requires all of the Xray’s energy to eject that electron from the atom 

  • the X ray becomes fully absorbed - and completely removed from the X ray beam 

  • contributes to contrast on the final image → the more Xrays that are removed from the beam - the less X rays are going to hit the detector, the more RADIOPAQUE / WHITER the image will look

  • the more X rays hit the detector - the darker, or more radiolucent the image will be  

  • ion is formed

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atoms with a higher atomic number …

  • more shells of electrons

  • more photoelectric interactions will be taking place 

  • more X rays will become absorbed 

  • less X rays hit the detector 

  • the whiter / more radiopaque the image will become 

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<p>photoelectric effect - consequence </p>

photoelectric effect - consequence

  • greater atomic number - more photoelectric interactions - more radiopaque 

  • contributes to contrast 

  • because the electron is ejected from the atom - it has a net positive charge - IONISING 

  • BUT contributes to dose 

<ul><li><p>greater atomic number - more photoelectric interactions - more radiopaque&nbsp;</p></li><li><p>contributes to contrast&nbsp;</p></li><li><p>because the electron is ejected from the atom - it has a net positive charge - <strong>IONISING&nbsp;</strong></p></li><li><p>BUT contributes to <strong>dose&nbsp;</strong></p></li></ul><p></p>
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what is Compton scatter ?

  • scatter occurs when an X ray interacts with an outer shell electron 

  • because outer shell electrons are further from the nucleus 

  • they have less strong attraction to the nucleus 

  • therefore less energy is required to eject one of these outer shell electrons from the atom 

  • only part of the Xrays energy is used to eject the electron 

  • electron is still ejected - ionising  STILL 

  • part of the Xray’s energy was required to eject the atom - X ray is redirected with less energy in a different direction - scatter 

<ul><li><p>scatter occurs when an X ray interacts with an <strong>outer </strong>shell electron&nbsp;</p></li><li><p>because outer shell electrons are further from the nucleus&nbsp;</p></li><li><p>they have less strong attraction to the nucleus&nbsp;</p></li><li><p>therefore less energy is required to eject one of these outer shell electrons from the atom&nbsp;</p></li><li><p>only part of the Xrays energy is used to eject the electron&nbsp;</p></li><li><p>electron is still ejected - ionising&nbsp; STILL&nbsp;</p></li><li><p>part of the Xray’s energy was required to eject the atom - X ray is redirected with less energy in a different direction - scatter&nbsp;</p></li></ul><p></p>
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Does Compton scatter still contribute to dose?

yes - because the atom still becomes ionised

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what is an issue with Compton scatter?

  • because the X ray is diverted after knocking an electron off - it hits the X ray detector at a different location than the correct anatomical point - reduces image quality and reduces contrast 

  • contributes to dose but doesn’t contribute to image quality 

we would prefer to have more photoelectric interactions instead

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what are the two main ways X rays affect molecules? (DNA molecules)

if atoms become ionised - the molecules that they are a part of can also become ionised 

  1. direct effect 

  2. indirect effect 

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direct effect of X rays on DNA molecules 

  • direct effect of X rays on DNA molecules 

  • minority of DNA damage 

<ul><li><p>direct effect of X rays on DNA molecules&nbsp;</p></li><li><p>minority of DNA damage&nbsp;</p></li></ul><p></p>
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Indirect effect of X rays on DNA molecules

  • interactions between X rays and water molecules 

  • water molecules become ionised - break down , they produce free radicals 

  • free radicals go on to damage the DNA 

  • majority of DNA DAMAGE

<ul><li><p>interactions between X rays and <strong>water </strong>molecules&nbsp;</p></li><li><p>water molecules become ionised - break down , they produce <strong>free radicals&nbsp;</strong></p></li><li><p><strong>free radicals go on to damage the DNA&nbsp;</strong></p></li><li><p><strong>majority of DNA DAMAGE </strong></p></li></ul><p></p>
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Interaction of X rays with cells - if DNA within a cell becomes damaged - what are the two potential outcomes?

  1. cell death 

  2. cell mutation 

<ol><li><p>cell death&nbsp;</p></li><li><p>cell mutation&nbsp;</p></li></ol><p></p>
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interactions of X rays with tissues

this depends on whether the X ray causes mutations or cell death 

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deterministic effects

dependent on cell death

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Stochastic effects (chance)effects

dependent on cell mutations

<p>dependent on cell mutations </p>
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<p>what is a deterministic effect?</p>

what is a deterministic effect?

  • ‘radiation burns’

  • effects that will definitely occur once a threshold dose is passed

  • (skin reddening, hair loss, cataracts)

  • caused by cell death

  • higher above the threshold dose that you go, the more severe the effects become 

  • before the threshold dose - it is impossible for these effects to occur 

  • in diagnostic imaging - the doses are so low, that it is impossible for these effects to occur 

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when do deterministic effects actually occur?

  • radiotherapy - when they have a cancer - inducing cell death in cancer cells

  • there will be collateral damage to healthy cells 

  • erythema to skin, hair loss, death of salivary gland cells - dry mouth 

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what are stochastic/chance effects?

  • may be induced by any dose of radiation - depends on the laws of probability

  • there is no safe dose

  • radiation induced cancers → if body cannot apoptose the mutated cell → malignancy may form

  • damage to cells based on mutations 

  • severity of the outcome is not dose dependent

  • probability of outcome is dose dependant

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<p>deterministic vs stochastic effects </p>

deterministic vs stochastic effects

note axis

dental imaging is far below threshold dose

3rd type of effect - stochastic genetic effects - these only occur if the reproductive organs are affected

<p>note axis </p><p>dental imaging is far <strong>below </strong>threshold dose </p><p><em>3rd type of effect - stochastic </em><strong><em>genetic </em></strong><em>effects - these only occur if the reproductive organs are affected </em></p>
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