KIN 217 - pentose phosphate pathway chapter 26

nucleotides

the pentose phosphate pathway will generate pentoses (5-c sugars)for what

NADPH

what electron carrier is made in the pentose phosphate pathway

cytoplasmic pathway

the other name for the pentose phosphate pathway is also known as

oxidation of NADPH

the first phase the pentose phosphate pathway will

nonoxidative interconversion of sugars

the second phase the pentose phosphate pathway will have the

true

the pentose phosphate pathway has a relationship between the phases and the metabolic need

t or f

liver, adipose

______ and ______ require large amounts of NADPH for FA synthesis

false

mammary glands don't use NADPH for lactation production

t or f

glucose-6-phosphate dehydrogenase

what enzyme oxidizes g-6-p to make a NADPH

water

after g-6-p is oxidized what of used to add a hydroxy molecule

ribulose 5-p, CO2, NADPH

what does the second round of oxidation of g-6-p produce

ketose, aldose

the 2nd stage of sugar interconversion will convert ribulose 5-p to ribose 5-p, which is turning a _______ to _______

xylulose 5-p

the alternative to making ribose 5-p from ribulose is what

phosphopentose isomerase

what enzyme makes ribose-5-p

phosphopentase epimerase

what enzyme makes xylulose 5-p

transaldolase, transketolase

ribose 5-p and xylulose 5-p can be used as substrates for _________ and _________ enzymes

2

how many sugar carbons can be transferred with transketolase

3

how many sugar carbons can be transferred with transaldolase

2,1

transketolase can rearrange 3 pentoses into ____ hexoses and ___ trioses

3, 7

using translocase with 2 riboses in rxn 1 will make C_ and C_

6, 4

rxn 2 uses the two substrates from rxn 1 (c3 and c7) to make C_ and C_

true

rxn 2 uses the two substrates from rxn 1 (c3 and c7) causing F-6-p to leave

t or f

C4

rxn 3 uses which product made from rxn 2

xylulose

during rxn 3 another _______ enters with the erythrose to make C6 and C3

glucose-6-phosphate dehydrogenase

which enzyme is the rate-limiting step of the pentose phosphate pathway

NADP+ conc

what is the most important regulatory factor in the pentose phosphate pathway

4

pathways uses a combo of oxidative phases, nonoxidative phases, glycolysis and gluconeogenesis for ___ modes based on oxidative needs

ribose 5-p

mode 1 occurs when __________ need exceeds the need for NADPH

balanced

mode 2 occurs when NADPH and ribose 5-p needs are ________

NADPH

mode 3 occurs when more ________ is needed than ribose 5-p

ATP

mode 4 occurs when NADPH and _____ are needed

mode 1

this mode uses glycolysis oxidative phase and non oxidative phase to make Ribose 5-p

fructose 6-p and GAP

Mode 1 can uses _______ and ______ to make ribose 5-phosphate

2

mode 2,3,4 makes how many NADPH

oxidative phase

mode 2 uses only uses which pathway

gluconeogenesis, oxidative and nonoxidative phase

mode 3 uses which pathway to make NADPH

2,2

mode 4 will make ___ NADPH and ____ ATP

false

ATP is made from DHAP in mode 4

t or f

glutathione

what enzyme is used to help scavenge ROS in the pentose phosphate pathway

NADPH

glutathione is used but will become oxidized which means it requires what for reducing powers