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what tissues heal by regeneration and which tissues repair by scarring?
regen: labile, stable
scar: permanent
which growth factors are involved in regeneration of epithelial cells?
EGF & TGF-alpha
what is healing by first intention?
epithelial regeneration
incised wounds w good edge apposition
what is healing by second intention?
combo of regen & repair
bigger deeper wound
more tissue granulation
collagen & wound contraction
what cytokine mediates type I collagen synthesis by fibroblasts?
TGF-beta
what is granulation tissue?
proliferating fibroblasts, new blood vessels, macrophages, inflammatory cells
what are the 2 main steps that leads deposition of connective tissue to scar formation?
migration & proliferation of fibroblasts into injury site
deposition of ECM by fibroblasts
how does corneal wound healing differ from skin or conjunctival wound healing?
no angiogenic stage
no granulation tissue
healing different depending on layer
what factors delay wound healing?
infection
vitamin C or copper or zinc deficiency
glucocorticoids (steroids)