[03-PRE-PCOL] DOSE RESPONSE RELATIONSHIP

Dose-response relationship

The relationship that exist between the effect to the body and relating in to the dose of the drug.

Dose-response relationship

This relationship is a systematic description of the extent of the effect of the degree of a drug as a function of its dose.

Dose-response relationship

A systematic description of the magnitude of the effect of a drug as a function of the dose (very low to very high)

Anti-hypertensive agents

Calcium blockers like amlodipine is classified as?

Blood pressure level

Anti-hypertensives can lower the elevated?

The greater is the effect of the drug achieved

The greater the dose of the drug, the?

Proportional

The dose of the drug will be ________ to the kind of therapeutic effect that will be achieved.

Dose-response curve

The existing relationship of those response or those to that of response can be easily illustrated through a systematic graph called?

x-axis

In dose-response curve, which axis plots the dose of the drug which is usually expressed in a logarithmic scale?

Log dose

Logarithmic scale is sometimes referred to as?

y-axis

In dose-response curve, which axis plots the response (which is equivalent to the measured effect of the drug or that could be the efficacy of the drug)?

Maximal achievable response to a drug

With the particular dose-response curve, we can be able to determine the efficacy of a certain drug, this is called the?

Potency

This is the dose that is required to achieve 50% of the maximum response.

50%

What would be the biomarker (potency) effective concentration to achieve the half of the maximum response.

Ceiling dose

The smallest dose that produces the maximum response.

Slope

This only describes the degree of change (the extent of change in the response or in the effect of drug if there is a slight change in the dose).

• Steep

• Non-steep

What are the two (2) types of slope?

Neutral antagonist

This type of antagonist has no receptor activity.

Surmountable

Competitive antagonism’s effect can be ________ if we increase the dose of the agonist.

Non-competitive antagonism

This type of antagonism is non-surmountable and the effect is irreversible.

Irreversible antagonist

We cannot stop its antagonism effect knowing that a non-competitive antagonist is involved.

Continuous scale

The graded dose-response curves, in general, shows effects on a _________ and the intensity of the effect is proportional to the dose.

Quantal Dose-Response Relationship

The distribution of minimum dose of a drug required to produce a defined degree of a specific response in a population of subjects.

All or none dose-effect

Quantal dose-response relationship is also known as?

Binary

Quantal dose-response relationship describes a drug effect which is?

Cumulative number of patients

In quantal dose-response relationship, the y-axis indicates the?

Log dose

In quantal dose-response relationship, the x-axis indicates the?

Therapeutic or toxic effect

In quantal dose-response curve, it only plots the response of a drug to a group of respondents showing these two effect as a function of its dose.

ED₅₀

Parameters involved in the Quantal Dose-Response Relationship Curve:

Median effective dose (the effective dose in 50% of the given population).

Median effective dose

ED₅₀ is also known as the?

TD₅₀

Parameters involved in the Quantal Dose-Response Relationship Curve:

Median toxic dose (toxic dose in 50% of the given population).

Median toxic dose

TD₅₀ is also known as?

Therapeutic index

Parameters involved in the Quantal Dose-Response Relationship Curve:

Measures the relative safety of the drug.

I = TD₅₀ / ED₅₀

What is the formulation of therapeutic index?

• Digoxin

• Warfarin

• Lithium

• Theophyline

What are the common examples of drugs with a narrow therapeutic index?

Margin of safety

Parameters involved in the Quantal Dose-Response Relationship Curve:

The same with the therapeutic index but now, it is TD₉₉ / ED₀₁