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What does a total fertility rate (TFR) of >2 indicate?
Population is growing
What does a total fertility rate (TFR) of <2 indicate?
Population is decreasing
What is considered a LBW?
<2,500g
What is considered a VBLW?
<1,500g
What is considered a very premature birth?
<32 weeks
What is considered a moderately premature birth?
32-33 weeks
What is considered a late premature birth?
34-36 weeks
What do Skene’s and Bartholin Glands do?
Produce mucus and provide lubrication, also aid sperm
What is the fundus?
Top of uterus
What is the cornua of the uterus?
Body of the uterus
What 3 layers does the myometrium consist of ?
Longitudinal (Outer), interlacing (middle), and circular fibers (Inner)
What 3 layers does the corpus consist of?
Endometrium, myometrium, perimetrium
What does endometrial milk do?
Assist sperm and provide nourishment for blastocysts
What happens to mucus at ovulation and why?
Becomes clearer and more alkaline to protect sperm
What is a karyotype?
Pictorial analysis of number, size, and form of chromosomes
What type of cell does mitosis produce?
Diploid
What type of cell does meiosis produce?
Haploid
What is the most common sex chromosome abnormality in females?
Turner syndrome (45,x)
What is the most common sex chromosome abnormality in males?
Klinefelter syndrome (47, XXY)
What age is a developing fetus the most vulnerable?
first 8 weeks
Considerations when using the basal body temperature method of contraception?
Check temperature every morning before arising
Use BBT monitor or tympanic that reads in tenths
Record 3 to 4 months
After ovulation, temp rise of 0.3-0.6 C or 0.5-1.0 F
Abstain from intercourse from day of slight drop in temp to 3 days from temperature increase
When does LH increase?
12-48 hours before ovulation
What drugs may decrease contraceptive effectiveness?
Anticonvulsants, antifungals, antibiotics, HIV protease inhibitors
Side effects of estrogen?
Alterations in lipid metabolism
breast tenderness
Fluid retention
headache
HTN
Nausea
Side effects of progestin
Acne, oily skin
Breast tenderness
Decreased libido
Depression
fatigue
hirsutism
weight gain
oligomenorrhea
Contraindications for hormonal contraceptives?
Pregnancy, hx stroke, heart disease, liver disease, gall bladder disease, heavy smoking, HTN, DBM
What are the two protective layers of the ovum called?
Zona pellucida and corona radiata
How long does it take for the sperm to reach teh ampulla?
2-7 hours, can survive 72 hours
What is the cortical reaction?
Reaction to stop other sperm from entering zona pellucida after one
What are the 3 stages of intrauterine development?
Preembryonic stage
Embryonic stage (day 15-8wks)
Fetal stage (every organ present)
What is cleavage in the fallopian tubes?
Rapid mitotic divisions
What is a morula?
Solid ball of 16 cells formed 3 days after conception
What is the blastocyst?
Structure that has differentiated into an inner cell mass and outer cell layer (inner embryoblast and outer trophoblast)
What is early pregnancy factor?
Immunosuppressant protein from trophoblastic cells that protect cells from the immune system
What is nidation and when does it occur?
embedding of fertilized ovum into the uterine mucosa. Occurs 5-10 days after fertilization
What are projections from the trophoblast extend into the maternal blood supply called?
Chorionic villi
What is the endometrium called after implantation?
Decidua
What is the decidua basalis?
Under the blastocyst, becomes maternal placenta
Where is the decidua parietalis
Lining the rest of the endometrium on the uterine cavity
What structures might ectoderms form?
Epidermis
hair follicles
CNS and PNS
What structures might mesoderms form?
Kidneys and ureters
Reproductive organs
Skeleton
Muscles
Cardiovascular system
What structures might endoderms form?
Respiratory tract epithelium
Lining of the digestive tract
Liver and pancreatic tissue
What is the chorion?
Outermost embryonic membrane
What is the amnion?
Inner membrane of embryo that encloses amniotic fluid
Functions of amniotic fluid?
Maintain body temp
Cushioning
Prevents adherence to amnion
Allows movement for musculoskeletal growth
Allows expansion of alveoli
Normal amount of amniotic fluid?
800-100ml
How long is the umbilical cord? How many arteries and veins?
30-90cm, 2 arteries 1 vein
What is Wharton’s jelly?
Connective tissue that prevents compression of blood vessels
What is a nuchal cord?
Cord around baby’s neck
What is a cotyledon?
Functional unit of the placenta
What week does the embryonic heart begin to function?
4 weeks
What functions is the placenta responsible for?
Respiration, nutrition, excretion, storage
What does progesterone cause in the uterus?
Decreases uterine contractility
What is estrogens role in fetal development
Proliferation of breast tissue, uterine growth, uterine-placental blood flow
When can a doppler be used to detect FHT
8-12 weeks
What is quickening and when can it first be felt?
First perception of fetal movement, 20 weeks
At how many weeks are primitive alveoli present?
24 weeks
What is lecithin?
Surfactant needed for expansion and stabilization of alveoli
What is sphingomyelin
Surfactant needed for expansion and stabilization of alveoli
What is the LS ratio about 1:1
29-32 weeks
When does surfactant production peak? What is the LS ratio
about 35 weeks, 2:1
what are dizygotic twins?
Fraternal twins (2 mature ovum from 2 separate sperm)
What are monozygotic twins
Identical twins, one fertilized ovum that divides
What is infant mortality rate?
number of infant deaths <1 year of age per 1000 live births
What is the highest cause of infant mortality?
Congenital abnormalities
What is the primary cause of maternal death in the U.S.?
Mental health
Where are Skene’s Glands and what do they do??
Located on both sides of the urethra and produce mucus for lubrication
Where are Bartholin’s glands and what do they do?
Located near vaginal orifice provide, lubrication and aid sperm
What is the pH of the vagina?
4.0-5.0
What is the corpus of the uterus?
Body of the uterus
What is the cornua of the uterus?
Where the fallopian tubes enter the uterus
What are the three layers of the uterus?
Endometrium, myometrium, and perimetrium
Where is the endometrium of the uterus?
Innermost layer of the uterus (monthly degeneration and assists sperm via enodmetrial milk)
Where is the myometrium of the uterus?
Middle layer
Where is the perimetrium of the uterus located?
Outermost layer
What happens to cervical mucus at ovulation?
Thins, clearer, more alkaline to protect sperm
What is the isthmus and ampulla of the fallopian tube?
Isthmus- narrow portion
Ampulla- Wider outer portion
What are the 2 main hormones associated with pregnancy?
Progesterone and estrogen
What is the symphisis pubis?
Joint where two pubic bones meet
What is the shortest part of the pelvic inlet?
Obstetric conjugate
What is the largest diameter of the pelvic inlet?
Transverse diameter
What is the shortest part of the midpelvis and entire pelvis?
Interspinous diameter (between ischial spines)
What is the shortest diameter of the pelvic outlet?
bi-ischial or inter-tuberous distance
Is a gynecoid pelvis favorable or unfavorable for child birth?
Favorable
Is a android pelvis favorable or unfavorable for child birth?
unfavorable
Is a anthropod pelvis favorable or unfavorable for child birth?
Favorable
Is a platypelloid pelvis favorable or unfavorable for child birth?
Unfavorable
What do broad ligaments of the uterus do?
Cover part of anterior and posterior uterus to stabilize uterus centrally
What do round ligaments of the uterus start and end?
From side of uterus near fallopian tube to labia majora
Where do cardinal ligaments of the uterus provide?
Chief uterine support (From side of uterus to true pelvis)
What do tubercles of montgomery do?
Sebaceous glands that provide lubrication to protect breast while infant sucks
What is primary amenorrhea?
No period by age 16 or 2 years after beast development. (potentially genetic systemic)
What is secondary amenorrhea?
Absence of menses for 3-6 months after regular periods. (assess medical history to determine cause)
What causes dysmenorrhea?
PID, endometriosis, endometrial polyps, STD
What is dysmenorrhea?
Painful menses
How is dysmenorrhea treated?
Pain management through ibuprofen, heat, massage, exercise, nutrition (Decrease salt, sugar), sometimes contraception
When do PMS symptoms begin and end?
Begin in the luteal phase. Symptoms from time of ovulation until onset of menses
Symptoms of PMS?
Fluid retention
weight gain
Behavioral or emotional irritability
Headaches, migraines, n/v
acne
Treatment of PMS?
Careful history and symptom tracking, exercise, decrease chocolate, cola, coffee, red meat, alcohol, nicotine
Symptoms of endometriosis?
Pelvic pain, painful intercourse, bleeding