three phases of wound healing

three aims of wound healing

to remove damaged tissue

to fill gap caused by tissue destruction

to restore structural continuity of injured part

would healing definition

restore lost functional tissue after injury

wound repair definition

reduce size of the damaged area

tissue repair definition

continuity of a tissues framework is restored

formation of scar tissue

three phases of wound healing

1. reactive phase
2. repair and proliferate phase
3. remodelling phase

reactive phase - time

1-3 days

reactive phase - process

wounds fill with clot and inflammatory cells

* creates a barrier between wound and outside environment
* initiates haemostasis

infiltration of neutrophils, mast cells, macrophages, and lymphocytes (WBCs)

reactive phase - clinical signs

redness

heat and pain

repair phase - time

3-10 days

repair phase - aim

close the wound

repair damaged tissue

repair phase - process

macrophages abundant in wound and angiogenesis begins

* formation of new blood vessels

fibroblasts migrate, proliferate, & secrete extracellular matrix

* some differentiate into myofibroblasts

myofibroblasts contain contractile fibres to knit would area

repair phase - granulation tissue

not as strong or thick as regular tissue

* proliferates overtime to increase density and strength

remodelling phase - time

10+ days

remodelling phase - aim

return normal tissue function

remodelling phase - process

re-epithelialisation of wound is complete

decrease cellular density

fibroblasts secrete remodelled extracellular matrix

scar formation with reduced tensile strength