Neuro2 L14 prion, protozoa, fungi

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10 Terms

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Toxoplasmosis

MC CNS parasite

Trophozoite, Bradyzoite (tissue cyst), sporozoite (feces)

Immunosuppressed

can be congenital

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Plasmodium Falciparum

Malaria

residual neuro damage

RBC rosettes

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Naegleria Fowleri

Primary amebic meningoencephalitis

thermophilic fresh water

sx identical to bacterial meningitis

phagocytic (RBC and brain)

food cup w/ enzymes

hemorrhagic CSF (increased RBC)

wet mount w/ motile trophozoites

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Acanthomoeba

Granulomatous amebic encephalitis

immunosuppressed

defend via humoral, complement and IgM/IgG

assoc w/ trauma (not swimming to diff from N Folweri)

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Trypanosomiasis

T brucei gambiense = west, human, slow

T brucei rhodesiense = east, zoonotic, rapid

kinetoplastids

acute blood stage → lymph invasion → relapse stage (antigenic variation)

cross BBB => meningoencephalitis

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Taenia Solium

neurocysticercosis => seizure and alt mental status

avoids immune sys (degrade Ab and inhibit phagocytosis)

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Echinococcus granulosus

dogs

hydatid cysts (scolices from daughter cells)- Praziquantel

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Angiostrongylus Cantonensis

snail/slug, rat

can see worm in vitreous humor

high IgM and IgE in serum, Ab in serum, brain lesion, larvae/worm in CSF

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Cryptococcus neoformans

India ink

yeast-like

pigeon poo

capsule, 37 C, phenol oxidase

cryptococcal meningitis

immunosuppressed

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Coccidioids Immitis

San Joaquin Valley Fever

coccidioidomycosis = true systemic mycosis

inhale

most virulent human mycotic agent

dimorphic

mold spore (arthroconidia)

spread to CNS => chronic granulomatous meningitis