M5: Manufacturing Pharmacy - Solid Dosage Forms - Part 3

Oldest method of coating which involves successive coating of sucrose-based solution.

a. Sugar coating

b. Film coating

c. Plastic coating

d. Glass coating

a. Sugar coating

Time consuming method and causes large increase in weight almost >50%.

a. Sugar coating

b. Film coating

c. Plastic coating

d. Glass coating

a. Sugar coating

Steps in sugar coating:

1- Color coating

2- Polishing

3- Sealing

4- Subcoating

5- Smoothing

a. 34512

b. 43512

c. 14352

d. 51342

a. 34512

Waterproofing wherein tablet core separates from water.

a. Sealing

b. Sub-coating

c. Smoothing

d. Color coating

e. Polishing

a. Sealing

Seal coating agents except:

a. Shellac

b. Cellulose acetate phthalate (CAP)

c. Polyvinyl acetate phthalate (PVAP)

d. Zein

e. None

e. None

Protein from corn.

a. Shellac

b. Cellulose acetate phthalate (CAP)

c. Polyvinyl acetate phthalate (PVAP)

d. Zein

d. Zein

Rounds off the edges and builds up the tablet size. It is the most critical step.

a. Sealing

b. Sub-coating

c. Smoothing

d. Color coating

e. Polishing

b. Sub-coating

Step that adds the most weight to the tablet.

a. Sealing

b. Sub-coating

c. Smoothing

d. Color coating

e. Polishing

b. Sub-coating

Alternate layers of sticky binder (acacia or gelatin) and dusting powder are agents for:

a. Sealing

b. Sub-coating

c. Smoothing

d. Color coating

e. Polishing

b. Sub-coating

Aka syruping as it use 60-70% syrup.

a. Sealing

b. Sub-coating

c. Smoothing

d. Color coating

e. Polishing

c. Smoothing

Critical step for tablet elegance.

a. Sealing

b. Sub-coating

c. Smoothing

d. Color coating

e. Polishing

d. Color coating

Color coating is usually done with 60-70% syrup + colorant.

a. True

b. False

a. True

Color coating steps that develops color.

a. Grossing

b. Heavy syruping

c. Regular syruping

a. Grossing

Color coating steps that builds up color.

a. Grossing

b. Heavy syruping

c. Regular syruping

b. Heavy syruping

Color coating steps for giving the final color.

a. Grossing

b. Heavy syruping

c. Regular syruping

c. Regular syruping

Optional step.

a. Sealing

b. Sub-coating

c. Smoothing

d. Color coating

e. Polishing

e. Polishing

Polishing agents except:

a. Beeswax

b. Carnauba wax,

c. Candelila wax

d. Hard paraffin wax

e. None

e. None

Involves deposition of thin film of polymer around the tablet core.

a. Sugar coating

b. Film coating

c. Plastic coating

d. Glass coating

b. Film coating

Coating with minimal increase in weight (2-3%) and easier and faster.

a. Sugar coating

b. Film coating

c. Plastic coating

d. Glass coating

b. Film coating

Component of film coating aside from film former except:

a. Plasticizer

b. Surfactant

c. Alloying Substance

d. Glossant

e. Volatile Solvent/Vehicle

f. None

f. None

Produces smooth, thin films.

a. Film former

b. Plasticizer

c. Surfactant

d. Alloying Substance

e. Glossant

f. Volatile Solvent/Vehicle

a. Film former

Non enteric film former except:

a. Celluloses

b. Methacrylate

c. PVA

d. PVP

e. None

e. None

Enteric film former except:

a. Shellac

b. Cellulose acetate pthalate

c. Polyvinyl acetate phthalate

d. Salol

e. None

e. None

Produces flexibility and elasticity.

a. Film former

b. Plasticizer

c. Surfactant

d. Alloying Substance

e. Glossant

f. Volatile Solvent/Vehicle

b. Plasticizer

Castor oil and glycerin are used as what?

a. Film former

b. Plasticizer

c. Surfactant

d. Alloying Substance

e. Glossant

f. Volatile Solvent/Vehicle

b. Plasticizer

Enhances spreadability of the fill.

a. Film former

b. Plasticizer

c. Surfactant

d. Alloying Substance

e. Glossant

f. Volatile Solvent/Vehicle

c. Surfactant

Polysorbates use in film coating.

a. Film former

b. Plasticizer

c. Surfactant

d. Alloying Substance

e. Glossant

f. Volatile Solvent/Vehicle

c. Surfactant

Provides water solubility/ permeability to the film.

a. Film former

b. Plasticizer

c. Surfactant

d. Alloying Substance

e. Glossant

f. Volatile Solvent/Vehicle

d. Alloying Substance

PEG.

a. Film former

b. Plasticizer

c. Surfactant

d. Alloying Substance

e. Glossant

f. Volatile Solvent/Vehicle

d. Alloying Substance

Provides luster or shine to the tablets without separate polishing operation.

a. Film former

b. Plasticizer

c. Surfactant

d. Alloying Substance

e. Glossant

f. Volatile Solvent/Vehicle

e. Glossant

Beeswax

a. Film former

b. Plasticizer

c. Surfactant

d. Alloying Substance

e. Glossant

f. Volatile Solvent/Vehicle

e. Glossant

Allows the spread of the other components over the tablets.

a. Film former

b. Plasticizer

c. Surfactant

d. Alloying Substance

e. Glossant

f. Volatile Solvent/Vehicle

f. Volatile Solvent/Vehicle

Alcohol + acetone

a. Film former

b. Plasticizer

c. Surfactant

d. Alloying Substance

e. Glossant

f. Volatile Solvent/Vehicle

f. Volatile Solvent/Vehicle

Coating defect:

Uneven color distribution due to poor mixing, uneven spray patterns, or migration of additives during drying.

a. Mottling

b. Sweating

c. Bridging

d. Erosion

e. Cratering

f. Blistering

a. Mottling

Coating defect:

Oily film or droplets of liquid due to humid conditions.

a. Mottling

b. Sweating

c. Bridging

d. Erosion

e. Cratering

f. Blistering

b. Sweating

Coating defect:

Markings are obscured due to coating solution filling in the logo of the tablet.

a. Mottling

b. Sweating

c. Bridging

d. Erosion

e. Cratering

f. Blistering

c. Bridging

Coating defect:

Removal of coating from the tablet surface due to friction themselves.

a. Mottling

b. Sweating

c. Bridging

d. Erosion

e. Cratering

f. Blistering

d. Erosion

Coating defect:

Craters appeared exposing the tablet surface due to disruption of coating at the crown when the surface is more porous.

a. Mottling

b. Sweating

c. Bridging

d. Erosion

e. Cratering

f. Blistering

e. Cratering

Coating defect:

Reduced adhesion and detachment of the film due to entrapment of gases underneath the film.

a. Mottling

b. Sweating

c. Bridging

d. Erosion

e. Cratering

f. Blistering

f. Blistering

Coating defect:

Fading or dulling of the film due to high concentration and low MW of plasticizer.

a. Blooming

b. Blushing

c. Twinning

d. Orange Peel

e. Flaking

f. Delayed Distribution

a. Blooming

Coating defect:

Whitish specks or haziness of the film due to precipitation of polymer at high temperature.

a. Blooming

b. Blushing

c. Twinning

d. Orange Peel

e. Flaking

f. Delayed Distribution

b. Blushing

Coating defect:

2 tablets stick together due to inappropriate tablet shape or tracky coating formulation.

a. Blooming

b. Blushing

c. Twinning

d. Orange Peel

e. Flaking

f. Delayed Distribution

c. Twinning

Coating defect:

Rough, non-glossy film surface due to inadequate spreading)

a. Blooming

b. Blushing

c. Twinning

d. Orange Peel

e. Flaking

f. Delayed Distribution

d. Orange Peel

Coating defect remedied by adding polysorbate surfactant.

a. Blooming

b. Blushing

c. Twinning

d. Orange Peel

e. Flaking

f. Delayed Distribution

d. Orange Peel

Due to thermal expansion of tablet cores caused by over drying.

a. Type I flaking

b. Type II flaking

a. Type I flaking

Due to core swelling caused by excessive moisture uptake

a. Type I flaking

b. Type II flaking

b. Type II flaking

Coating defect:

Film cracking

a. Blooming

b. Blushing

c. Twinning

d. Orange Peel

e. Flaking

f. Delayed Distribution

e. Flaking

Coating defect:

Associated with the exposure of tablet cores to coating process conditions rather than a direct effect of the applied coating.

a. Blooming

b. Blushing

c. Twinning

d. Orange Peel

e. Flaking

f. Delayed Distribution

f. Delayed Distribution

Shells are manufactured in a separate operation from filling.

a. Hard gelatin capsules

b. Soft gelatin capsules

a. Hard gelatin capsules

Most common method of manufacturing hard gelatin capsules.

a. Pin method

b. Plate method

c. Rotating die method

a. Pin method

Steps in filling hard gelatin capsules.

1- Joining/closing

2- Ejection

3- Finishing

4- Rectification

5- Separation

6- Filling

a. 213457

b. 123456

c. 345612

d. 456123

d. 456123

Orienting empty shells properly with bodies facing forward.

a. Rectification

b. Separation

c. Filling

d. Joining/closing

e. Ejection

f. Finishing

a. Rectification

HGC sealing technique:

Seals with a band of gelatin

a. Gelatin Banding

b. Heat Welding

c. Thermal Coupling

a. Gelatin Banding

HGC sealing technique:

Fuses cap to body through double wall thickness.

a. Gelatin Banding

b. Heat Welding

c. Thermal Coupling

b. Heat Welding

HGC sealing technique:

Uses liquid wetting agent to lower melting point between cap and body then bonds.

a. Gelatin Banding

b. Heat Welding

c. Thermal Coupling

c. Thermal Coupling

Formed, filled and sealed in a single operation.

a. Hard gelatin capsules

b. Soft gelatin capsules

b. Soft gelatin capsules

Methods of preparing SGC:

Oldest method which uses gelatin sheets.

a. Plate Process

b. Rotary Die Process

c. Reciprocating Die Process

a. Plate Process

Methods of preparing SGC:

Uses gelatin ribbons brought together between 2 rotating dies.

a. Plate Process

b. Rotary Die Process

c. Reciprocating Die Process

b. Rotary Die Process

Methods of preparing SGC:

Uses gelatin ribbons brought together between 2 rotating dies in opposite process.

a. Plate Process

b. Rotary Die Process

c. Reciprocating Die Process

c. Reciprocating Die Process

Norton capsule machine.

a. Plate Process

b. Rotary Die Process

c. Reciprocating Die Process

c. Reciprocating Die Process