1.5 SA ectoparasite meds

Dog licenced oral meds (8)

• Nitenpyram

• Fluralaner (Bravecto)

• Afoxolaner (NexGard)

  • + milbemycin (NexGard spectra)

• Sarolaner (Simparica)

  • + moxidectin + pyrantel (Simparica trio)

• Lotilaner (Credelio)

  • + milbemycin (Credelio+)

Cat licenced oral meds (2)

• Nitenpyram

• Lotilaner (Credelio)

  • Only isozaxoline oral for cats

Nitenpyram admin+ flea/tick/mite activity

• Admin

  • Dogs + cats (oral)

• Flea exclusive

  • Very fast but not persistent

  • Knockdown = before surgery or heavy flea load

• No tick or mite activity

Bravecto admin + flea/tick/mite activity + side effects

Fluralaner

• Admin

  • Dogs (oral (best), spot on, injected (>6 month olds))

  • Cats (spot on)

• Fleas

  • Slowest isoxazoline but most persistent (12w)

  • Injected is extremely persistent (beware ADR) = 12 months

• Ticks

  • Ixodes + Dermacentor = good 12h killing, persists 12 weeks

  • Rhipicephalus = good 12h killing, persists 8w

• Mites

  • Demodex + Sarcoptes = single dose enough!

  • (unlicenced for Otodectes but can persist 12w)

• Side effects

  • GI signs (1.8% dogs)

  • Risk of exacerbating seizure

Bravecto plus admin + activity

Fluralaner + moxidectin

• Cats only (spot on)

• Moxidectin adds nematodes

NexGard admin + flea/tick/mite activity

Afoxolaner → widest spec isoxazoline (all mites and ticks!)

• Admin

  • Dogs only (oral best)

• Fleas

  • Faster than fluralaner (Bravecto)

  • 5w persistence (same as sarolaner (Simparica))

• Ticks

  • Ixodes + Dermacentor + Rhipicephalus

  • Slow acting (bad 12h) but good at 24h

  • 4w persistence

• Mites

  • Demodex + Sarcoptes + Otodectes

  • 2x 1m apart

Nexgard spectra admin + activity

Afoxolaner + milbemycin

• Dogs only (oral) = same as afoxo

• Milbemycin adds nematodes (esp lungworm)

Nexgard combo admin + activity

Afoxolaner + praziquantel + eprinomectin

• Cats only (spot on)

• Praziquantel adds cestodes

• Epirinomectin adds nematodes

Simparica admin + flea/tick/mite activity

Sarolaner

• Admin

  • Dogs only (oral best, also spot on)

• Fleas

  • Fastest isoxazoline

  • 5w persistence (same as afoxolaner/nexgard)

• Ticks

  • Ixodes + Dermacentor

  • 5w persistence

• Mites

  • Demodex = 3+ 1m apart

    • Limiting factor = normally 3 doses of Simparica/month

  • Sarcoptes = 2+ 1m apart

  • Otodectes = single dose or 2× 1m apart

Simparica trio admin + activity

Sarolaner + moxidectin + pyrantel

• Dogs only (oral) = same as saro

• Moxidectin + pyrantel add nematodes

• ½ sarolaner:

  • NOT LICENCED FOR OTODECTES

  • Extra doses may be needed for Demodex and Sarcoptes

Stronghold plus admin + activity

Sarolaner + selamectin

• Cats + rarely dogs (spot on)

  • Good for cats = very broad spec

• Selamectin adds nematodes

• Demodex or quick recovery (unlicenced) = 2× 2w apart

Credelio admin + flea/tick/mite activity

Lotilaner

• Admin

  • CATS and dogs (oral)

• Fleas

  • 1m (4w) persistence - shortest isoxazoline

  • (speed unspecified)

• Ticks

  • 1m (4w) persistence

  • (affects all 3 species but was independently researched)

• Mites

  • Only licensed for demodex

Credelio plus admin + activity

Lotilaner + milbemycin

• Dogs ONLY (oral)

  • (NOT CATS)

• Milbemycin adds nematodes (esp lungworm)

Seresto admin + flea/tick/mite activity

Imidacloprid (advantage) + flumethrin (cat nontoxic pyrethroid)

• Admin

  • Dogs + cats (collar)

• Fleas (imidacloprid = insecticide)

  • Slow speed initially (leaches to skin)

  • Kills fleas within 36h → before laying eggs!

  • 7-8m persistence (LONG!)

• Ticks (pyrethroid → FAST)

  • Ixodes (kill + antifeeding) = 100% in 6h

  • Dermacentor (kill)

  • 8m persistence (LONG!)

• No mite effect

Advantix admin + flea/tick/mite activity

Imidacloprid (advantage) + permethrin (pyrethroid)

• Admin

  • Dogs only (spot on)

  • Pyrethroids (not flumethrin) toxic to cats!

• Fleas (imidacloprid = insecticide)

  • Kills fleas within 36h → before laying eggs!

  • 4w persistence

• Ticks (pyrethroid → FAST)

  • Ixodes + Dermacentor + Rhipicephalus

  • EXTREMELY QUICK = kill before blood meal (no diseases)

  • 4w persistence

• No mite effect

Advocate admin + flea/tick/mite activity

Imidacloprid (Advantage) + moxidectin

• Admin

  • Dogs + cats + FERRETS (spot on)

• Fleas (imidacloprid = insecticide)

  • Kills fleas within 36h → before laying eggs!

  • 4w persistence

• No tick effect

• Mites (moxidectin)

  • Demodex + Sarcoptes (licenced) = 2× 1m apart

    • Kills 50% demodex…

  • Demodex or quick recovery (unlicenced) = 2× 1w apart

    • Kills 80% demodex!

Indorex admin + flea/tick/mite activity

Pyroxiprofen

• Admin

  • Environment spray

• Fleas

  • IGR = prevents pupal moult

  • Adults still seen

• Flea exclusive = no tick/mite activity

Programme admin + flea/tick/mite activity

Lufenuron

• Admin

  • Long acting injection

  • (was oral in the past)

• Fleas

  • Chitin synthesis inhibitor = prevents larvae breaking out of egg

  • Adults still seen

• Flea exclusive = no tick/mite activity

Ivermectin admin + flea/tick/mite activity + side effects

Unlicenced for ectoparasites, group 3 anthelmintic (macrolac)

• Admin

  • Oral (clear drench)

• Mites

  • Demodex = kills 100% in 4 months

  • Daily dose

• Flea and tick activity not mentioned (but since endectocide = assume present)

• Side effect

  • Bad in collies = no blood brain barrier multidrug transporter

Milbemycin admin + flea/tick/mite activity + side effects + coformulation

Unlicenced for ectoparasites, group 3 anthelmintic (macrolac)

• Admin

  • Oral (clear drench)

• Mites

  • Kills demodex (presumably similar to ivermectin)

• Flea and tick activity not mentioned

  • (but since endectocide = assume present)

• Side effect

  • Bad in collies = no blood brain barrier multidrug transporter

• Coformulations → used to kill nematodes:

  • NexGard spectra (+ afoxolaner)

  • Credelio plus (+ lotilaner)

Drugs VS ixodes + persistence (5)

• Fluralaner (Bravecto) → 12w

• Afoxolaner (NexGard) → 4w

• Sarolaner (Simparica) → 5w

• *Lotilaner (Credelio) → 1m (~4w)*

• Flumethrin (in seresto collar) → 8m

  • Kill + antifeed

• Permethrin → 4w

  • FAST → prevent refeeding

Drugs VS dermacentor + persistence (5)

Same as ixodes:

• Fluralaner (Bravecto) → 12w

• Afoxolaner (NexGard) → 4w

• Sarolaner (Simparica) → 5w

• *Lotilaner (Credelio) → 1m (~4w)*

• Flumethrin (in Seresto collar) → 8m

  • Kill (NOT ANTIFEED LIKE IXODES)

• Permethrin (in Advantix spot on) → 4w

  • FAST → prevent refeeding

Drugs VS rhipicephalus + persistence (3)

• Fluralaner (Bravecto) → 8w

  • Ixodes/Dermacentor for 12w

• Afoxolaner (NexGard) → 4w

• *Lotilaner (Credelio) → 1m (~4w)*

• Permethrin (in Advantix spoton) → 4w

(No sarolaner and flumethrin)

Drugs VS Demodex + dosage (5+5)

• Fluralaner (Bravecto) → 1x

  • Injected unlicenced

• Afoxolaner (NexGard) → 2× 1m apart

• Sarolaner (Simparica) → 3+ 1m apart

  • S. trio → halved dose → more frequent!

  • Stronghold+ → 2× 14d apart

• Lotilaner (Credelio) → not stated, but Dem only

• Moxidectin (in advocate spot on)

  • Licenced (kills 50%) → 2× 1m apart

  • Unlicenced (kills 80%) → 2× 1w apart

• Ivermectin (kills 100+ in 4m)

• Milbemycin

Drugs VS sarcoptes + dosage (4+1)

• Fluralaner (Bravecto) → 1x

  • Injected unlicenced

• Afoxolaner (NexGard) → 2× 1m apart

• Sarolaner (Simparica) → 2+ 1m apart

  • S. trio → halved dose → more frequent!

• Moxidectin (in advocate spot on) → 2× 1m apart

Drugs VS otodectes + dosage (2+1)

• Fluralaner (Bravecto)

  • Persists 12w

• Afoxolaner (NexGard) → 2+ 1m apart

• Sarolaner (Simparica) → 1-2 1m apart

  • S. trio → halved dose → do NOT USE!

Common licenced drugs VS fleas (8)

• Nitenpyram

  • High speed (3h)

  • Low persistence

• Fluralaner (Bravecto)

  • Slowest iso → FAS

  • 12w (oral/spot on) persistence

  • (12m persistence if injected)

• Afoxolaner (NexGard)

  • Moderate speed

  • 5w persistence

• Sarolaner (Simparica)

  • Fastest iso

  • 5w persistence

• Lotilaner (Credelio)

  • 1m (4w) persistence

• Imidacloprid + flumethrin (Seresto)

  • Collar = slowest onset

  • Kills fleas in 36h → before laying eggs!

  • 7-8m persistence

• Imidacloprid (Advantix + advocate)

  • Kills fleas in 36h → before laying eggs!

  • 4w persistence