tb-induced addison's + waterhouse-friedrichsen

how much of the adrenal gland needs to be destroyed for adrenal insufficiency to present?

>90%

how does TB cause addison's?

TB spreads to adrenal glands, causes inflammation, necrosis and destruction of adrenal cortical tissue

does TB usually affect the adrenal glands uni- or bilaterally?

bilaterally

what are the symptoms are tb-induced addisons? (12)

- anorexia

- weight loss

- fatigue

- muscle weakness and myalgia

- salt craving

- GI problems

- dizziness

- headache

- depression and behavioural changes

- reduced libido

- reduced axillary hair

- sweating

what are the signs of TB-induced addison's? (5)

- hyperpigmentation

- postural hypotension

- dehydration

- vitiligo or goitre

- pyrexia

what is waterhouse-friderichsen syndrome?

adrenal haemorrhage caused by a severe bacterial infection which then causes adrenal gland failure

what is the most common cause of waterhouse-friderichsen syndrome?

neisseria meningitidis infection