clinical chem exam 1

accuracy

how close the result is to the true value

trueness

how close the values provided by a method to the true value

repeatability

do you get the same results in the same conditions

reproducibility

do you get the same results in different conditions

imprecision

random error

bias

systematic error

analyte

specific substance that is measured

sample matrix

everything (but analyte) in a substance

calibration

relationship between the concentration of a substance and the signal generated by the analyte

primary standard

pure solution of an exactly known concentration of an analyte

secondary standard

solution (usually from a body fluid) for which the analyte has an assigned value

quality control

identifying potential changes in an analytical setting

analytical sensitivity

how small of a difference in analyte concentration can be reliably measured

analytical specificity

ability to test how a system reacts with only a specific analyte and not other substances

clinical sensitivity

tests the percentage of patients with a disease who yield an abnormal test result (true positive)

clinical specificity

test the percentage of patients without a disease who yield a normal test result (true negatives)