Medchem II final Drugs match

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Last updated 1:29 PM on 4/30/26
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28 Terms

1
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Vorinostat

HDAC inhibitor (grabs onto zinc metal on HDAC, preventing de-alkylation)

<p>HDAC inhibitor (grabs onto zinc metal on HDAC, preventing de-alkylation)</p>
2
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Romidepsin (Fk228)

HDAC inhibitor (prodrug - disulfide bond needs reduction)

<p>HDAC inhibitor (prodrug - disulfide bond needs reduction)</p>
3
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Penicillin G

Beta lactam/penicillin, inhibits peptidoglycan = no cell wall

<p>Beta lactam/penicillin, inhibits peptidoglycan = no cell wall</p>
4
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Clavulanic acid

Lactamase inhibitor, irreversible (break open the box then nucleophilic attack-attach for good)

<p>Lactamase inhibitor, irreversible (break open the box then nucleophilic attack-attach for good)</p>
5
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Vancomycin

Glycopeptides, forms 5 H-bonds with pentapeptide on gram POSITIVE stuff

<p>Glycopeptides, forms 5 H-bonds with pentapeptide on gram POSITIVE stuff</p>
6
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Penem

Box with N attached to five member S ring

Penicillin (PBP inhibitor, gram POSITIVE)

<p>Box with N attached to five member S ring</p><p>Penicillin (PBP inhibitor, gram POSITIVE)</p>
7
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Cephem

Box with N attached to SIX member S ring

(PBP inhibitors, gram POSITIVE and NEGATIVE)

<p>Box with N attached to SIX member S ring</p><p>(PBP inhibitors, gram POSITIVE and NEGATIVE)</p>
8
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Carba penem/ Thienamycin

The most potent antibiotic + beta-lactamase resistance

gram POSITIVE and NEGATIVE

<p>The most potent antibiotic + beta-lactamase resistance </p><p>gram POSITIVE and NEGATIVE</p>
9
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Carba cephem / Loracarbef

gram POSITIVE and NEGATIVE

<p>gram POSITIVE and NEGATIVE</p>
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Sulbactam

Lactamase inhibitor (irreversible)

<p>Lactamase inhibitor (irreversible) </p>
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Tazobactam

Lactamase inhibitor (irreversible)

<p>Lactamase inhibitor (irreversible) </p>
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Avibactam

DABCO-based inhibitor (Reversible covalent)

<p>DABCO-based inhibitor (Reversible covalent)</p>
13
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MK7655

DABCO-based inhibitor (Reversible covalent)

<p>DABCO-based inhibitor (Reversible covalent)</p>
14
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Ceftaroline

beta lactamase resistant transpeptidase inhibitor

NOT lactamase inhibitor but can inhibit

<p>beta lactamase resistant transpeptidase inhibitor </p><p>NOT lactamase inhibitor but can inhibit</p>
15
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Monobactams

Just one ring. Target PBP and beta-lactamases, ending to drug-protein complexes

<p>Just one ring. Target PBP and beta-lactamases, ending to drug-protein complexes</p>
16
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Tunicamycin

competitive MRA-Y inhibitor (Cannot remove sugar in stage 1)

<p>competitive MRA-Y inhibitor (Cannot remove sugar in stage 1) </p>
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Erythromycin

Ketolides, inhibit bacterial protein synthesis

<p>Ketolides, inhibit bacterial protein synthesis</p>
18
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Imipenem

Carba-penems

<p>Carba-penems </p>
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Talavancin

Vancomycin analogue (more lipophilic, can penetrate both gram NEGATIVE and positive)

<p>Vancomycin analogue (more lipophilic, can penetrate both gram NEGATIVE and positive)</p>
20
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Dalbavancin

Vancomycin analogue (more lipophilic, can penetrate both gram NEGATIVE and positive)

<p>Vancomycin analogue (more lipophilic, can penetrate both gram NEGATIVE and positive)</p>
21
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Chlorobiphenyl Vancomycin

Biphenyl structure

Vancomycin analogue (more lipophilic, can penetrate both gram NEGATIVE and positive)

<p>Biphenyl structure</p><p>Vancomycin analogue (more lipophilic, can penetrate both gram NEGATIVE and positive)</p>
22
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Oritavancin

Biphenyl structure

Vancomycin analogue (more lipophilic, can penetrate both gram NEGATIVE and positive)

<p>Biphenyl structure</p><p>Vancomycin analogue (more lipophilic, can penetrate both gram NEGATIVE and positive)</p>
23
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Ciprofloxacin

Fluoroquinolone, Bacterial DNA gyrase inhibitor (inhibit DNA replication)

<p>Fluoroquinolone, Bacterial DNA gyrase inhibitor (inhibit DNA replication)</p>
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Levofloxacin

Fluoroquinolone, Bacterial DNA gyrase inhibitor (inhibit DNA replication)

<p>Fluoroquinolone, Bacterial DNA gyrase inhibitor (inhibit DNA replication)</p>
25
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Teicoplanin

Glycopeptides (Like vancomycin)

<p>Glycopeptides (Like vancomycin)</p>
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Caprazamycin

MRA-Y inhibitor

<p>MRA-Y inhibitor </p>
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Muraymycin

MRA-Y inhibitor

<p>MRA-Y inhibitor</p>
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Ramoplanin

Vancomycin analogue (ORAL ONLY), dual inhibitor (Binds base material, block transglycosylation, block tranpeptidation)

<p>Vancomycin analogue (ORAL ONLY), dual inhibitor (Binds base material, block transglycosylation, block tranpeptidation)</p>