Micro E3 pt 1

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146 Terms

1
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True fungal pathogens owe their virulence to thermal dimorphism. Define thermal dimorphism.

A change in form that is triggered by a change in temperature

2
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Which class of fungal pathogens are transmissible by sharing infected towels and gym mats?

Dermatophytes

3
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Which class of fungal pathogens develop long term immunity?

True pathogens

4
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List the fungal pathogens discussed.

histoplasmosis, coccidioidomycosis, blastomycosis, Paracoccidioidomycosis, sporotrichosis, chromoblastomycosis, mycetoma, dermatophytes

5
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Which true fungal pathogens cause Ohio River Fever?

Histoplasma capsulatum

6
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Where is Histoplasma capsulatum most prevalent?

Midwestern and Southeastern US – follows the Ohio river valley

7
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What type of soil does Histoplasma capsulatum thrive in?

Soil high in nitrogen content, especially in soil containing bird and bat droppings

8
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What environments are associated with outbreaks of Histoplasma capsulatum?

Construction sites, parks, old buildings: where humans disturb spores

9
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Describe the symptoms associated with a primary lung infection caused by Histoplasma capsulatum.

Mild cough, myalgias, malaise, +/- fever, night sweats, wt loss

10
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Describe the microscopic appearance of Histoplasma capsulatum on a sputum smear.

Spherical “fish-eye” yeasts in macrophages

11
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What true fungal pathogen causes coccidioidomycosis (Valley fever)?

Coccidioides immitis

12
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What activities are commonly associated with outbreaks of Coccidioides immitis?

Farming, archeological digs, landslides, dust storms

13
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What geographic location would you most likely find Coccidioides Immitis?

Southwestern US; especially in the San Joaquin Valley of California and southern Arizona

14
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What are the Coccidioides immitis cells in the parasitic state called?

spherules

15
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What pulmonary findings are consistent with severe coccidioidomycosis?

Fungomas: cavitary lesions/nodular growths in the lungs

16
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What is the treatment for disseminated Coccidioides?

Itraconazole or fluconazole; Amphotericin B for severe cases

17
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Blastomycosis is caused by which true fungal pathogen?

Blastomyces dermatitidis

18
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What geographical location and environment is Blastomyces dermatitidis primarily found?

Midwestern and Southeastern US: forests, decaying wood, animal manure

19
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Describe the microscopic appearance of Blastomyces dermatitis in sputum.

Large, ovoid yeasts w/ broad-based buds; “tiny lollipops”

20
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Is serological testing recommended in Blastomycosis infections?

No, low sensitivity can cause false negatives and there is a high degree of cross-reactivity w/ other mycoses

21
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What are the primary symptoms in blastomycosis pulmonary infection?

Flu-like sx, fever, chills, productive cough, myalgias, pleuritic chest pain

22
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Which two true fungal pathogens cause paracoccidioidomycosis?

Paracoccidioides brasiliensis and Paracoccidioides lutzii

23
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What geographical location are you most likely to find the pathogens that cause Paracoccidioidomycosis?

Mexico, Central and South America -most often Brazil

24
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What occupations are you most likely to find the pathogens that cause Paracoccidioidomycosis?

Rural agricultural workers and plant harvesters

25
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Describe the microscopic appearance of Paracoccidioidomycosis brasiliensis

Large, round or oval mother yeast cells w/ multiple attached narrow-necked buddying daughter yeast cells (“pilot’s wheel”) or mother yeast cell possessing only 2 attached daughter bud (“Mickey mouse head”)

26
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Define subcutaneous mycoses.

Fungi are transferred directly into traumatized skin and can invade

27
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What subcutaneous mycoses cause Rose-Gardener’s disease?

Sporothrix schenckii

28
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Describe the clinical appearance of lymphocutaneous sporotrichosis.

Primary sore is accompanied by a series of nodules running along the lymphatic channels of the arm; advanced stages have ulcers and necrosis

29
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What is the first line of treatment of lymphocutaneous sporotrichosis? Will heat applications help?

Itraconazole; heat will help resolve smaller infections

30
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What is another name for Mycetoma?

Madura foot

31
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What are the most causative fungi of Mycetoma?

Pseudallescheria or Madurella

32
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Define cutaneous mycoses.

Infections strictly confined to the stratum coreum and epidermal tissues

33
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Name the term that classifies cutaneous mycoses.

Dermatophytosis (tinea)

34
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Name three dermatophytes discussed in class.

Tichophyton, Microsporum, Epidermophyton

35
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List the medical term and the clinical presentation of scalp ringworm.

Tinea capitis: ranges from small, scaly patches to destruction of the hair follicle and permanent hair loss

36
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List the medical term and the clinical presentation of beard ringworm.

Tinea barbae “barber’s itch”: ichty, nodules along the chin and beard of adult males

37
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List the medical term and the clinical presentation of body ringworm.

Tinea corporis: inflamed, raised, scaly, red rings w/ serpigionous borders anywhere on smooth skin

38
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List the medical term and the clinical presentation of groin ringworm.

Tinea cruris: “jock itch”; itchy, red, perineum groin, scrotal regions

39
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List the medical term and the clinical presentation of foot ringworm.

Tinea pedis: peeling, scaly lesions that spreads in a “moccasin” pattern

40
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List the medical term and the clinical presentation of nail ringworm.

Tinea unguium: thickening, accumulation of debris, cracking, discoloration; nail bed may become separated

41
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List the medical term and the clinical presentation of hand ringworm.

Tinea manuum: occurs between digits and along the palms

42
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What dermatophyte genera is most involved with tenia pedis?

Trichophyton

43
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What would you find on a ring “wormy boi” positive skin scraping heated with KOH?

Branching, fungal mycelium

44
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Define superficial mycoses.

Involves only the outer epidermal surface (non-invasive)

45
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Name the fungal pathogens associated with white Piedra and describe its clinical presentation.

Trichosporon beigelii: whitish/yellowish colored masses develop on the shaft of scalp, pubic, or axillary hair

46
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Name the fungal pathogens associated with black Piedra and describe its clinical presentation.

Piedraia hortae: dark-brown/black gritty nodules, mainly on scalp hairs but can be found on beard, mustache, and pubic hairs

47
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Which superficial mycoses is caused by Malassezia furfur?

Tinea versicolor

48
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Describe the clinical presentation of Tinea versicolor.

Mild, chronic scaling and causes a mottled discolored skin pigmentation

49
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 Name the three topical medications or classification of medication involved in treatment of Tinea versicolor.

Antifungals (azoles, terbinafine, ciclopirox), selenium sulfide, zinc pyrithione

50
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Name the opportunistic fungal pathogen that is often the cause of candidiasis.

Candida albicans

51
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Describe the finding on a KOH slide in a patient with candidiasis.

Budding cells of varying size

52
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Describe the clinical findings in oropharyngeal candidiasis and the patient population you would most likely this in.

“thrush” -thick, white adherent growth on mucous membranes of the mouth and throat: newborns, elderly, debilitated pts

53
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Describe the clinical findings in esophageal candidiasis and the patient population you would most likely see each.

Painful, bleeding ulcerations, N/V: HIV/ immunocompromised pts

54
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Describe the clinical findings in vulvovaginal candidiasis and the patient population you would most likely see each.

Itchy, whitish discharge, ulcerations, inflammation: adult women (inc risk when taking oral antibiotics, diabetic or pregnant)

55
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Describe the clinical findings in cutaneous candidiasis.

Can occur anywhere on the skin w/ the correct environment; red, itchy, can produce a scald-like rash on neonates

56
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Describe the clinical findings in intertriginous candidiasis.

Occurs in moist skin folds; red, itching

57
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What is onychomycosis?

Fungal infection of the nail

58
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Which opportunistic fungal pathogen causes cryptococcosis?

Cryptococcus neoformans

59
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In which population would you see the disseminated form of Cryptococcosis?

Pts w/ AIDS, cancer, or diabetes

60
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What type of stain is used to diagnosis cryptococcosis? Describe the microscopic findings.

India ink: halos around large spherical yeast cells

61
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The opportunistic fungal pathogen Pneumocystis jirovecii causes what type of pneumonia in AIDs patients?

Pneumocystis pneumonia (PCP)

62
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Why is amphotericin B a poor choice for treatment for AIDS pts w/ Pneumocystis pneumonia?

PCP lacks ergosterol making it uneffective

63
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What is the recommended medication to Pneumocystis pneumonia?

Sulfamethoxazole/trimethoprim (Bactrim)

64
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What two species of aspergillus are known to cause human illness?

Aspergillus fumigatus and Aspergillus flavus

65
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What occupation is most associated with Aspergillus infections?

Farmers who breathe in clouds of conidia from the air of barns and silos

66
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What is Aspergilloma?

Fungus balls formed in the lungs from spores of Aspergillus

67
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What disease is caused by eating poisonous mushrooms?

Mycotoxicoses

68
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What is the name of the most deadly wild mushroom?

Amanita phalloides “death angel”

69
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How many trophozoites does a mature Entamoeba histolytica cyst release?

4

70
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What is the clinical presentation of symptomatic intestinal amebiasis? What other organs are most commonly involved?

Dysentery, abdominal pain, fever, diarrhea (blood, mucus), wt loss; often also affects the liver, and sometimes the lungs, and heart

71
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Which organism is known as a “brain-eating amoeba”?

Naegleria fowleri

72
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Where is this Naegleria fowleri typically found?

Warm, standing water

73
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What is the most effective drug against N. fowleri?

Amphotericin B

74
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What type of protozoan is Balantidium coli?

Ciliated protozoa

75
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How does a human acquire a Balantidium coli infection?

Ingesting cyst-containing food or water

76
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What symptoms could Balantidium coli cause?

N/V, dysentery, abdominal colic

77
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Which species of trichomonas causes a STD?

Trichomonas vaginalis

78
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What percentage of individuals with T. vaginalis are asymptomatic carriers?

70%

79
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What symptoms would women infected with T. vaginalis present with?

Foul-smelling, green/yellow frothy discharge; vulvitis; cervicitis; urinary frequency and dysuria

80
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What symptoms would men infected with T. vaginalis present with?

Urethritis; prostatitis; thin, milky discharge

81
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Giardia intestinalis AKA Giardia lamblia is usually found in what bodies of water?

Untreated water from a mountain stream or spring

82
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Describe what the trophozoite form Giardia looks like.

Heart shaped; paired nuclei that resemble an “old man w/ glasses”

83
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Describe the clinical presentation of Giardia.

Diarrhea, abdominal pain, dehydration, wt loss, flatulence

84
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Name the organism and vector associated with African sleeping sickness.

Trypanosoma brucei; tsetse fly

85
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Describe the first sign of infection and list the late symptoms associated with African sleeping disease.

Trypanosomal chancre -> intermittent fever, splenomegaly, LAD, arthralgia -> CNS, changes in personality, behavior, lassitude, sleep disturbances, etc

86
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Name the organism and the vector associated with Chagas disease.

Trypanosoma cruzi; Reduviid bug (“kissing bug”)

87
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Which organs are primary sites for chronic infection in Chagas disease?

Heart and brain

88
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Name the vector associated with leishmaniasis.

Sand flies

89
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Describe the clinical findings in cutaneous leishmaniasis.

Persistent skin lesions that start as small red papules -> darker and crust -> ulcer surrounded by dusky red skin

90
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What are the primary causes of death in visceral leishmaniasis?

Hemorrhage, severe anemia, or secondary bacterial infections of mucous membranes

91
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Which genre of apicomplexan parasites cause malaria?

Plasmodium

92
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Describe the clinical presentation of malaria?

Fever paroxysms, Non-specific, may include tachycardia, tachypnea, chills, malaise, fatigue, diaphoresis, HA, cough, anorexia, N/V, abd pain, diarrhea, arthralgia, myalgias, +/- splenomegaly and hepatomegaly

93
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What abnormalities will you see on a CBC in a patient with malaria?

Hemolytic anemia and thrombocytopenia

94
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Describe the common findings on a peripheral blood smear of pts with malaria.

Ring-form trophozoites

95
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Which apicomplexan parasite is associated with cat feces and eating undercooked lamb, beef, and pork?

Toxoplasma gondii

96
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What disease does Toxoplasma gondii cause?

Toxoplasmosis

97
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What two patient populations are at a significant risk if they develop Toxoplasmosis?

Fetus (via placenta) and AIDS pts

98
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Which bodies of water are most associated with cryptosporidium? Why?

Contaminated drinking or recreational water due to its resistant to chlorine disinfection

99
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Which organism causes cyclosporiasis?

Cyclospora cayetanensis

100
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How soon do cyclosporiasis symptoms start after ingestion?

7 days