Asynchrony (“bucking the vent”)
Auto-PEEP causing air trapping and alveolar damage
Barotrauma (alveolar damage from pressure/volume)
Hemodynamic compromise
Nosocomial infection
Anxiety, stress, sleep deprivation
Gastric ulcers, gastritis, malnutrition
Muscle deconditioning and ventilator dependence
Increased intrathoracic pressure causing systemic edema from decreased venous return