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Superior
Toward the head or upper part of a structure or the body; above.
Inferior
Away from the head or toward the lower part of a structure or the body; below.
Dorsal
Toward the back side of the body; posterior.
Ventral
Toward the belly or front side of the body; anterior.
Superficial
Closer to or on the body surface.
Deep
Farther from the body surface; more internal.
Proximal
Closer to the point of attachment of a limb to the trunk.
Distal
Farther from the point of attachment of a limb to the trunk.
Medial
Toward the midline of the body.
Lateral
Away from the midline of the body.
Anterior
Toward the front of the body; ventral.
Posterior
Toward the back of the body; dorsal.
Cell
Basic structural and functional unit of life.
Tissue
Group of similar cells that perform a common function.
Organ
Structure composed of at least two tissue types that performs a specific function.
Organ system
Group of organs that work together to accomplish a common purpose.
Epidermis
Superficial layer of skin made of stratified squamous epithelium that provides a protective barrier.
Dermis
Deep connective-tissue layer of skin containing blood vessels, nerves, and glands.
Hypodermis
Subcutaneous layer of adipose and areolar tissue that anchors skin and insulates the body.
Melanocyte
Pigment-producing cell in the epidermis that synthesizes melanin.
Keratin
Tough, waterproofing protein found in epidermal cells.
Sweat gland
Skin gland (eccrine or apocrine) that secretes perspiration for thermoregulation.
Sebaceous gland
Oil gland associated with hair follicles that secretes sebum.
Arrector pili muscle
Small smooth muscle that elevates hair, producing ‘goosebumps.’
Thermoregulation
Physiological control of body temperature via mechanisms like sweating and vasoconstriction.
Cartilage
Flexible connective tissue with chondrocytes; cushions joints and forms parts of the skeleton.
Endochondral ossification
Process in which cartilage models are replaced by bone during development and growth.
Bone marrow
Soft tissue in bones; red marrow forms blood cells, yellow marrow stores fat.
Osteon
Structural unit of compact bone consisting of concentric lamellae around a central canal.
Periosteum
Dense connective-tissue membrane covering the outer surface of bone.
Skeletal muscle
Striated, multinucleated muscle attached to bones; under voluntary control.
Smooth muscle
Non-striated, single-nucleated muscle in walls of hollow organs; involuntary.
Cardiac muscle
Striated, branched muscle of the heart with intercalated discs; involuntary.
Sarcolemma
Plasma membrane of a muscle fiber.
Sarcomere
Contractile unit of muscle fiber between two Z lines.
Sarcoplasmic reticulum
Specialized smooth ER in muscle fibers that stores and releases calcium.
T-tubule
Invagination of the sarcolemma that conducts action potentials into the muscle fiber interior.
Tendon
Dense regular connective tissue cord attaching muscle to bone.
Ligament
Dense regular connective tissue band connecting bone to bone.
Aponeurosis
Broad sheetlike tendon connecting muscles to bones or other muscles.
Actin
Thin filament protein that interacts with myosin during muscle contraction.
Myosin
Thick filament motor protein that pulls actin to shorten sarcomeres.
Troponin
Regulatory protein on actin that binds calcium to initiate contraction.
Tropomyosin
Protein that covers actin’s binding sites when the muscle is relaxed.
Neuromuscular junction
Synapse between a motor neuron and a skeletal muscle fiber.
Acetylcholine
Neurotransmitter released at neuromuscular junctions to trigger muscle contraction.
Central nervous system (CNS)
Brain and spinal cord; integrates and processes information.
Peripheral nervous system (PNS)
All neural tissue outside the CNS; carries information to and from the CNS.
Neuron
Excitable cell that transmits electrical impulses.
Dendrite
Branched neuronal process that receives incoming signals.
Axon
Long neuronal process that carries impulses away from the cell body.
Myelin sheath
Lipid-rich covering around some axons that speeds impulse conduction.
Astrocyte
Star-shaped glial cell that supports neurons and forms the blood–brain barrier.
Oligodendrocyte
CNS glial cell that forms myelin sheaths around axons.
Microglia
Phagocytic glial cell that removes debris and pathogens in the CNS.
Ependymal cell
Ciliated glial cell lining brain ventricles; produces and circulates cerebrospinal fluid.
Synapse
Junction where a neuron communicates with another cell via neurotransmitters.
Presynaptic cell
Neuron that releases neurotransmitter into a synapse.
Postsynaptic cell
Cell that receives and responds to neurotransmitter at a synapse.
Synaptic cleft
Narrow gap between pre- and postsynaptic membranes.
Neurotransmitter
Chemical messenger that transmits signals across a synapse.
Action potential
Rapid electrical impulse that travels along the membrane of an excitable cell.
Cerebrospinal fluid (CSF)
Clear fluid that cushions the CNS and circulates nutrients; produced by the choroid plexus.
meninges
Three protective membranes—dura mater, arachnoid mater, pia mater—surrounding the CNS.
Pons
Brainstem region that relays signals between cerebrum and cerebellum and helps regulate breathing.
Medulla oblongata
Brainstem region that controls vital reflexes such as heart rate and respiration.
Cerebellum
Brain region that coordinates movement, posture, and balance.
Thalamus
Brain relay station for sensory information headed to the cerebral cortex.
Hypothalamus
Brain region that regulates homeostasis, autonomic functions, and endocrine activity.
Cerebrum
Largest brain region responsible for conscious thought, memory, and voluntary action.
Frontal lobe
Cerebral lobe for motor control, planning, reasoning, and personality.
Parietal lobe
Cerebral lobe processing somatosensory information.
Occipital lobe
Cerebral lobe that processes visual information.
Temporal lobe
Cerebral lobe involved in hearing, language, and memory.
Afferent (sensory) nerve
Carries impulses toward the CNS from receptors.
Efferent (motor) nerve
Carries impulses away from the CNS to effectors.
Dorsal root
Posterior spinal cord root carrying sensory (afferent) fibers.
Ventral root
Anterior spinal cord root carrying motor (efferent) fibers.
Sympathetic nervous system
Autonomic division active during ‘fight-or-flight’ situations.
Parasympathetic nervous system
Autonomic division active during ‘rest-and-digest’ conditions.
Cornea
Transparent front layer of the eye that refracts incoming light.
Lens
Biconvex eye structure that focuses light onto the retina.
Retina
Innermost eye layer containing photoreceptors.
Photoreceptor
Retinal cell (rod or cone) that converts light into nerve impulses.
Rod
Photoreceptor sensitive to low light and responsible for black-and-white vision.
Cone
Photoreceptor responsible for color vision and sharp detail.
Vitreous humor
Gel filling the posterior eye that maintains shape.
Aqueous humor
Clear fluid in the anterior chamber of the eye that nourishes cornea and lens.
Pupil
Opening in the iris that regulates the amount of light entering the eye.
Hair cell
Mechanoreceptor in the cochlea and vestibular apparatus that detects sound or movement.
Semicircular canals
Three fluid-filled loops in the inner ear that detect rotational movement.
Utricle
Vestibular sac that detects horizontal acceleration.
Saccule
Vestibular sac that detects vertical acceleration.
Static equilibrium
Sense of head position relative to gravity.
Dynamic equilibrium
Sense of rotational or angular movement.
Negative feedback
Control mechanism in which the response reduces or shuts off the original stimulus.
Humoral stimulus
Hormone release triggered by changing blood levels of ions or nutrients.
Hormonal stimulus
Hormone release triggered by other hormones.
Neural stimulus
Hormone release triggered by nervous system input.
Growth hormone (GH)
Anterior pituitary hormone that stimulates tissue growth and repair.