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Host Range
Determined by availability of a suitable receptor the virus is able to bind to
Lock and Key Mechanism
Virus attaches to cell membrane via surface receptors allowing entry into cell
How does a virus enter a cell?
Fusion, endodcytosis, rearrangement of capsid
What does a virus do once it is inside the cell?
Gets uncoated to allow for replication in either cytoplasm or at nuclear membrane
Growth Curve of Virus Replication: Eclipse
Uncoating of virus particles following adsorption
Growth Curve of Virus Replication: Latent Period
Viral nucleic acid replicates and protein synthesis occurs
Growth Curve of Virus Replication: Maturation Period
Virus nucleic acid and protein are assembled into mature virus particles and visions are released
Seroconversion
Period where antibodies are produced in response to infection or immunization, usually only detected 14-21 days after infection
How do viral proteins affect normal cell function?
Inhibit DNA, RNA, or protein synthesis, change antigenic surface of cell, induce malignancy, stimulates inflammation, forming syncytial (giant multinucleated cells)
Syncytium
When uninfected and infected cells fuse together to form a giant multinucleated cell, will eventually become too large and rupture
