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What does pharmacokinetics study?
The time course of ADME
What are the primary goals of PK?
Enhance efficacy and decrease toxicity
Define kinetic homogeneity
Describes the PREDICTABLE relationship between Cp and concentrations at receptor site where drug produces its effect
What is the graphical relationship between Cp and Ct when KH is true
Cp and Ct are proportional
T or F: there are exceptions to KH
True, not all drugs display KH
Define pharmacodynamics
The relationship between drug concentration at the SITE OF ACTION and the RESULTING PHARMACOLOGICAL EFFECT
What determines a drug’s effect?
Interaction and binding with a receptor (not all pharm. action is receptor mediated)