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Central Nervous System (CNS)
brain and nerve cord; brain and spinal cord in vertebrates
Peripheral Nervous System (PNS)
All neurons and their projections that are outside of the CNS
Nerve systems that have classes of cells
Neurons (nerve cells) and glia (neural glial cells)
Neurons
cells that send and receive electrical and chemical signals to form each other and other cells throughout the body
Neurons are present in all animals except ?
Sponges
What varies widely as a function of size and behavioral complexity?
Neurons
Cell Body or Soma
Contains nucleus and organelles
Dendrites
extension of cell body, single or branching; receive incoming signals
Axon
extension of cell body; carries signals to other cells (away from cell body); typically single, varies widely in length
What has branches and may be wrapped in myelin?
Axon
Glia
Surround neurons and perform numerous functions; 1000x more numerous than neurons
Astrocytes
Metabolic support; maintain stable concentration in ions in extracellular fluid
Microglia
Participate in immune functions; remove cellular debris
Myelin Sheath
Sheath is interrupted in non-insulated nodes of ranvier
Types of Glia
Astorcytes, Microglia, Myelin Sheath, Oligodendrocytes (CNS); Schwann cells (PNS), radical glial cells
3 Main Types of Neurons
Sensory neurons, motor neurons, interneurons
Sensory Neurons
Detect information from the outside world or internal
Sensory Neurons are also called?
Afferent neurons
Motor Neurons
Send signals away from CNS (efferent neurons) to elicit response
Interneurons
Form interconnections between other neurons; critical interpretation of information and elicited response
Reflex Arc
Stimulus from sensory neurons sent to CNS, little or no interpretation ( few or no interneurons), signals transmitted to motors neurons to elicit response;
Is reflex arc a quick and automatic response?
Yes
Membrane Potential
Gatekeeper
What generates electrical signals?
Neurons and Muscle Cells
Why is the cell polarized?
Due to membrane’s permeability
What causes both chemical and electrical differences (imbalances)?
Differences in ions between inside/outside of neuron
Inside is what?
Negative
Outside is what?
Positive
When a neuron is NOT sending a signal, it is selectively permeable to what?
Cations (+) and Anions (-)
Where are most ions located?
Most ions are near the edge of the membrane because anions on the inside are drawn to the cations on the outside.
Electro-chemical gradient
Imbalance due to differences inside/outside of neuron
Chemicals
K+, Na+, Cl -
3 Factors contributing to resting potential
Sodium Potassium Pump, Polarity, Ion Specific channels allow pass ion movement
Sodium-Potassium Pump
Requires ATP expenditure; Pump 3 Na+ for every 2 K+
Ion Specific channels allow passive ion movement
Membrane is more permeable to K; K channels more frequently open at resting potential
Polarity
More (-) inside neuron
Gated Ion Channels
Voltage-gated and Chemical-gated
Voltage-gated
Open/close in response to voltage changes
Chemical-gated
Open/close in response to chemical
Frequency
Language of the message; higher the frequency, the greater the excitation level
Resting Potential
Imbalance between K+ and Na+ inside/outside; Membrane selectively permeable to K, but channels closed for Na and Cl
Outside Neuron of Resting Potential
10x more Na, 5x more Cl
Inside Neuron of Resting Potential
30x more K
Action Potential
Rapid/brief change of a nerve fiber; electrical potential of the impulsive; “Self propagating”; After a passing given point, membrane returns to resting
At give impulse point what happens in Action Potential?
Channels for Na open and Na diffuses in, K is already diffusing out, but increased at impulse
Sodium/Potassium Pump
Complex of proteins in membrane; Pump out Na and carry in K; Returns the imbalance “normally”, movement is from low concentration to a high concentration