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The spontaneous electrical activity generated by the heart that is produced by regular muscle contractions is known as
heart rate
HR X SV =
CO
An electrical disorder that presents with pacer spikes is known as
ectopic pacemaker activity
Types of cardiomyopathies
-Dilated
-Hypertrophic
-Restrictive
Myocardial cell membrane ions include:
Na+, K+, Ca+
Myocardial cell membrane proteins include:
-Gap junction
-pumps
-transporters
Which 'pacemaker' cells initiate activity?
SA node
3 multiple choice options
___________ produces electrical properties that are like pacemaker cells.
AV node
Which ectopic beat is normally generated within the atria?
PAC
1 multiple choice option
Ectopic activity is promoted by:
hypoxia
ischemia
hyperkalemia
3 multiple choice options
A First degree heart block is described as an AV block with
prolonged PR interval
3 multiple choice options
Which AV block has P waves that are not all followed by a QRS complex due to temporary failure of AV conduction?
Second Degree AV block
2 multiple choice options
Which form of AV block features intermittent non-conducted P waves without progressive prolongation of the PR interval?
Second degree Mobitz II
2 multiple choice options
Which arrhythmia occurs when an accessory pathway between atria and ventricles bypass the AV node completely while setting up a reentrant circuit?
WPW
2 multiple choice options
Which AV block features progressive PR lengthening before non-conducted P wave?
Second degree Mobitz I
1 multiple choice option
Third degree AV block is also known as
Complete AV block
What is the MC chronic rhythm disturbance initiated by ectopic foci at junction of atria with pulmonary veins?
A fib
2 multiple choice options
Which condition develops if the supply of coronary blood cannot meet the demand of the myocardium for oxygen and nutrients?
Transient MI
Patient presents with chest pain that has been unpredictable. What is the most likely dx?
Prinzmetal angina
or
unstable angina
3 multiple choice options
Basis of altered perfusion of tissues due to impaired cardiac functioning or excessive workload demands that cannot be met is known as
CHF
The transient episodes of vessel occlusion and vasoconstriction occur at the site of plaque damage, allowing for perfusion return before significant necrosis occurs is known as
unstable angina (reversible myocardial ischemia)
3 multiple choice options
Which condition causes death of myocardial tissue due to lack of O2?
MI
What condition occurs at the site where endothelial damage and plaque formation blocks or slows blood flow?
atherosclerosis disease
What transports lipids to peripheral tissues once absorbed into the small intestine?
chylomicrons
Substances that injure endothelial cells in vessels:
-glucose
-inflammation
-lipoproteins
-free radicals
-nicotine
-homocysteine
What is responsible for the increased water and electrolyte reabsorption and the kidney and is part of the compensatory body mechanism?
RAAS system
What disease results in the entanglement of poorly formed blood vessels in the brain?
Arteriovenous malformation (AVM)
Which disease is promoted by the influx of inflammatory cells within the adventitia induced by Angiotensin II, causing vessel formation?
Angiogenesis
A compelling argument for the cause of atherosclerosis in AAA may be due to:
arterial remodeling
Which congenital disorder can cause high-pressure blood flow that can cause vessel expansion, which may lead to a rupture in the weakened aneurysm in the brain?
Brain arteriovenous malformations (bAVMS)
Causes of AAA
-Arterial luminal stenosis develops
↳changes in the media cause shear stress
↳ECM matrix remodeling promotes artery expansion
-elastin breaks → diffusion of inflammatory cytokines and provides stimulation for chronic inflammation
Which arrhythmia results from decreased intrinsic pacemaker function or blocks in conduction, within the AV node or Purkinje fiber system?
Bradyarrhythmia
1 multiple choice option
Which arrhythmia is described as irregular heartbeats starting above the lower heart chambers with episodes of pounding beats suddenly starting and stopping?
SVT
Which arrhythmia occurs when there is repeated reentry of stimuli to the atrioventricular (AV) node?
A fib
2 multiple choice options
Which arrhythmia occurs when the ventricles replace the SA node as a pacemaker?
V tach
3 multiple choice options
CAD, MI, structural cardiac conditions, cardioversion, hypoxic states, congenital disease (Marfan syndrome, tetralogy of Fallot, Kawaski's disease, WPW, and long QT syndrome predisposes patient to
V fib
3 multiple choice options
causes of CAD:
chronic interruption of blood flow
↳ischemia/infarction
-genetic
-risk factors
causes of DVT:
-venous stasis
-vessel wall injury
-hyperoacgulability
-pregnancy
-excessive clotting disorder
Venous stasis ulcer
inefficient blood returns to heart & increased venous pressure in the lower extremities causes backflow into capillary exchange beds, leakage of serous fluid, and vein rupture, which leads to inflammatory substances causing ulceration
What is caused by scarring, thickening, calcification, vegetation of the valve, resulting in the sympathetic nervous system compensating low cardiac output, leading to heart failure?
aortic stenosis
Recurrent inflammation of the small and medium arteries of the legs results in thrombus formation in young men who are smokers because the tobacco products trigger an autoimmune response in these young men, and loss of arterial blood flow occurs. What is this condition called?
Thromboangiitis obliterans/Buerger's disease
Macrophages that envelop triglycerides and LDLs are known as
foam cells
Foam cells enlarging caused by more LDL, macrophages, platelets, and smooth muscle fibers which narrow the vessels occurring in the early stages of atherosclerosis cause:
fatty streak
modifiable risk factors in CAD
-smoking cessation
-healthy diet
-exercising
Higher blood pressure in CAD is caused by a "fatty streak" and the formation of calcium deposits due to
reduced blood flow in small coronary vessels
What is the gold standard for CAD diagnosis?
Cardiac catheterization
What condition arises from diminished blood flow to the heart muscle causing the sympathetic nervous system to raise BP + HR; increasing the O2 and glucose needs leading to necrosis and scar formation?
MI
What condition is characterized by the backup of fluid caused by excessive preload, leading to afterload which cannot overcome the workload due to increased PVR?
CHF
What condition is caused by bacteremia post-throat infection causes vegetation on the heart valves with general inflammation of all layers and all structures of the heart?
Rheumatic endocarditis
What can cause cardiogenic shock?
-Decreased contractility of the ventricles
-↓ CO to all organ systems caused by toxic levels of some drugs
-pericarditis
-stenosis of heart valves leading to cardiac arrest
-fatal arrhythmias
-renal failure
-stroke
Enlargement of the heart muscle/chambers of the heart caused by myocarditis, chronic cocaine use, autoimmune disease, HIV, and inherited or chronic alcohol use (thiamine deficiency)
Cardiomyopathy