Linkage, Recombination and Eukaryotic Gene Mapping

Flashcards covering key terms and concepts from the lecture on linkage, recombination, and gene mapping.

Gene mapping

Determination of the location of a gene on a chromosome.

Genetic mapping

Mapping based on recombination.

Physical mapping

Mapping based on physical landmarks.

Linked Genes

Genes located close together on the same chromosome.

Complete linkage

Genes on the same chromosome that are so close there is no crossing over between them.

Incomplete linkage

Genes on the same chromosome that are far enough apart to allow crossing over.

Genetic Recombination

The sorting of alleles into new combinations.

Non-recombinant gametes

Gametes that have the same allele combinations as the parental gametes.

Recombinant gametes

Gametes that have different allele combinations than the parental gametes.

Recombination Frequency

Percentage of recombinant progeny produced in a cross.

Map Units (m.u.)

A unit of measure for genetic distances based on recombination frequency.

Interference

One crossover physically inhibits the formation of a second crossover.

Wild-type

The typical form of a species or trait; often the dominant phenotype.

Complementation test

A test used to determine if two mutations are in the same or different genes.

RFLP (Restriction Fragment Length Polymorphisms)

Variations in DNA sequences detected by cutting DNA with restriction enzymes.

Microsatellites

Tandem repeats in DNA that can be used as genetic markers.