Hematology Review (Quiz Questions)

An MCV of 78 fL would be described as

microcytic

Which is the preferred anticoagulant for coagulation testing?

sodium citrate

The basophhilic appearance of the cytoplasm in immature cells is due to the presence of:

RNA

A patient with a cold agglutinin will likely produce which of the following CBC results?

A)Hgb = 7.4g/dL & Hct = 32.4%

B)MCHC = 40.0 g/dL

C)MCV = 112.3 fL

D)All

All

How many microliters are in a liter?

1,000,000

A low hgb value would be obtained from a patient with which of the following conditions?

A) Rouleaux

B) Iron Deficiency

C) Cold Agglutinin

D) High Protein Diet

Iron Deficiency

A CBC includes an automated differential. T? F?

True

As a cell matures the N:C ratio gets closer to 1:1. T? F?

False

The cellular element that acts as a garbage collector for the body is the

Macrophage

A hgb value of 5.4g/dL and a HCT of 17.8% are acceptable to report. T? F?

True

Blood obtained from a finger puncture is what type of specimen?

Capillary

Hypochromic RBC's will demonstrate which test results?

MCHC

Which component has iron in the ferrous state?

Hemoglobin

Which of the following vacutainer tubes will recover plasma when centrifuged?

A)EDTA

B)SST

C)Red Top

D)All

EDTA

Which are possible reasons for having an H & H fail the rule of 3?

A) Icterus

B) Hemolysis

C) Lipemia

D) All

All

There are 0.01 centimeters in 1 meter. T? F?

False

Which cellular element is formed from a megakaryocyte?

thrombocytes

Match the cellular characteristic with the appropriate cell.

-Cell mediated immunity

-Increased in bacterial infections

-Increased in hypersensitivity reactions

-Humoral immunity

-First cell of the neutrophilic series to normally be seen in the peripheral blood

-Increased in viral infections

-Increased in allergic reactions

-Immature form of a histiocyte

T-Cell

Segmented Neutrophil

Basophil

B-Cell

Band

Lymphocyte

Eosinophil

Monocyte

Match the morphologic characteristic with the appropriate cell.

-large cell with convulted, smooth chromatin in the nucleus

-bilobed nucleus with reddish-orange granules

-nucleus buried under blue-black granules

-nuclues has 2-4 lobes with a pinkish colored cytoplasm

-round nucleus with clumped chromatin

Monocyte

Eosinophil

Basophil

Segmented Neutrophil

Lymphocyte

Which component comprises approximately 46% of whole blood?

erythrocytes

There are 10(12) _____ in 1 gram.

picograms

Which hormone initiates the production of platelets?

thrombopoietin

Allowing the alcohol to air dry during the venipuncture procedure will prevent:

hemolysis

How can the laboratorian assure that patient results are accurate?

the quality control samples are within range

Hgb Portland

Hgb Gower I

Hgb A

Hgb F

Hgb A2

2 zeta, 2 gamma

2 zeta, 2 epsilon

2 alpha, 2 beta

2 alpha, 2 gamma

2 alpha, 2 delta

When anticoagulated whole blood is centrifuged the volume of packed red blood cells is known as the:

Hematocrit

The hematocrit is usually __________ the hemoglobin.

3 times greater than

The earliest stage of erythrocyte maturation that may normally be seen in the peripheral blood:

reticulocyte

Which of the following abnormal RBCs would be considered discretionary (meaning you must see 5-10 / field before being called) in identifying RBC morphology?

A) acanthocytes

B) dacryocytes

C) leptocytes

D) all of the above

leptocytes

After the age of 5 years, the blood contains the following percent of Hgb-F

< 1%

Hgb F has a higher affinity for oxygen than Hgb A T? F?

True

Hemoglobin A is known as:

normal adult hemoglobin

In the function of respiration, hemoglobin is found primarily in an oxygen saturated form called:

oxyhemoglobin

Heinz bodies can be seen on a peripheral smear stained with Wright's stain. T? F?

False

Mature red blood cells are biconcave disk composed primarily of hemoglobin. T? F?

True

-RBC stains bluish-gray on peripheral smears

-normal RBC

-RBC with decreased concentration of hgb

-Variation in RBC size

-Variation in RBC shape

Polychromasia

Erythrocyte

Hypochromia

Anisocytosis

Poikiolocytosis

Which of the following has a basophilic cytoplasm and an eccentric nucleus with a visible halo around it?

plasma cell

Hemoglobin with iron in the Ferric state cannot bind oxygen and is known as:

Methemoglobin

RNA is present in a mature erythrocyte T? F?

False

A substance that has a greater affinity than oxygen for binding to hemoglobin is:

carbon monoxide

The life span of an erythrocyte is about:

4 months

Reticulocytes are a salmon color on a peripheral smear. T? F?

False

List 3 factors that affect the oxygen affinity of hemoglobin.

1. pH

2. Temperature

3. Partial pressure CO2

Match the RBC morphology with its appropriate description.

-Sickle cell

-Pencil cell

-Irregularly-shaped projections

-Hyperchromic cell

-Tear drop cell

-Crenated RBC

-Red cell fragment

-Mouth like cell

-Target cell

Drepanocyte

Elliptocyte

Acanthocyte

Spherocyte

Dacryocyte

Echinocyte

Schistocyte

Stomatocyte

Leptocyte

Match the RBC inclusion with its appropriate composition

-RNA

-DNA

-microtubule spindles

-denatured hemoglobin

-iron

RNA-Basophilic Stippling

DNA-Howell Jolly Bodies

MS-Cabot Ring

Hem-Heinz Bodies

Iron- Pappenheimer Bodies

Cell indices obtained on a patient are as follows:MCV = 102.5 fl; MCH = 30 pg; MCHC = 34 g/dl; RDW = 15.3% The RBCs on the peripheral smear would appear:

Macrocytic / Normochromic

Which of the following is a protein that is produced by one leukocyte that stimulates or has an effect on another leukocyte?

interleukin

A siderocyte may be identified when using which of the following stains?

prussian blue

What type of cell is easily indented by RBC's, is increased in viral infections, has an increase basophilia (particularly intense near the periphery) and has a nucleus that is frequently elongated?

reactive lymphocyte

List the order of the developmental stages of a RBC starting with the most IMMATURE

Pronormoblast

Basophilic normoblast

Polychromatophilic normoblast

Orthochromic normoblast

Reticulocyte

Erythrocyte

Which of the following RBC morphology could be considered artifact?

A) acanthocytes

B) drepanocytes

C) schistocytes

D) stomatocytes

stomatocytes

How does a decrease in pH affect the hemoglobin-oxygen dissociation curve?

Curve shifts to the right

Plasma lacks fibrinogen. T? F?

False

Which area of the slide is used to scan for fibrin strands and platelet clumps?

swiss cheese

Which objective is used to perform a WBC estimate on a peripheral smear?

40x

Which organ(s) is/are part of the RES?

A) bone marrow

B) liver

C) spleen

D) all of the above

All

What component of the manual differential does not use oil immersion to view the smear?

WBC Estimate

What is the Corrected WBC if 26 NRBC were seen on a 100 cell differential from a patient with a 18.4 x 10(9)/L white count? (all answers in units of 10(9)/L)

14.6

When calculating the manual WBC count, what value is used for the # of quadrants counted?

4

90% of RBC destruction occurs extravascularly. T? F?

True

How many squares are in the center quadrant of a hemocytometer?

25

After estimating the average number of WBC seen in 8-10 fields the technician multiplies this number by what factor to obtain the WBC estimate?

2000

What amount of EDTA whole blood is used in a 1:100 dilution unopette system?

20uL

Which of the following is the correct formula for calculating a manual cell count?

(# of cells counted x dilution x 10) / # of quadrants counted

Iron is transported to the bone marrow by:

transferrin

When performing the platelet estimate the average number of platelets seen in 8-10 fields is multiplied by what factor?

20,000

The largest portion of urobilinogen is excreted in the urine. T? F?

False

Which area of the slide will have WBC's that are NOT distorted and RBC's that show a normal central pallor?

monolayer

A manual WBC count resulted in an average of 36 cells counted in 4 quadrants on a Neubauer ruled hemacytometer. A 1:20 dilution was used. What is the final WBC count? (all values given in units of 10(9)/L)

1.8

Iron is stored as:

ferritin

In hemoglobin destruction globin components are returned to the amino acid pool. T? F?

True

Urobilinogen is a breakdown product of _____.

bilirubin

The objective used to perform the WBC differential is the:

high, oil

In order for hemoglobin to combine reversibly with oxygen, the iron must be:

In the ferrous state

In the normal adult, the spleen acts as a site for:

Removal of imperfect and aging cells

After the removal of red blood cells from the circulation, hemoglobin is broken down into:

Iron, protoporphyrin ring & globin

Which area of a peripheral smear is used to identify RBC morphology?

monolayer

In intravascular destruction of RBCs hemoglobin breaks down to dimers which bind with:

haptoglobin

What could be done if a differential is ordered on a patient with a WBC of 0.8 x 10(9)/L?

make a buffy coat smear

Which of the following is the formula for absolute cell count?

% of cells counted x total count

What is the hemacytometer volume counted in a WBC count?

0.4 cubic mm

What is the total number of quadrants on 1 side of the hemacytometer?

9

Which area of a peripheral smear is described as showing large spaces between the cells and the RBCs have no central pallor.

feather edge

In RBC destruction iron and globin are both conserved and recycled. T? F?

True

Calculate the MCHC using the following values: Hgb: 15 g/L; RBC 4.5 x 106/µL; Hct: 47%.

31.9%

A genetically transmitted type of hemolytic anemia caused by a decreased rate of synthesis of one of the polypeptide chains of hemoglobin is called:

thalassemia

What is (are) the basic cause(s) of anemias?

increased RBC destruction or loss

The Morphologic Classification of Sideroblastic Anemia is:

Microcytic / Hypochormic

Hemoglobinopathy that has an amino acid substitution of valine for glutamic acid at the sixth position on the beta globin chain is:

Hgb S

The following are seen on a peripheral smear of a patient with a moderate anemia:

Moderate Anisocytosis

Moderate Poikliocytosis with sickle cells, target cells, Howell Jolly bodies, polychromasia, and few nRBCs

Which disease would best fits this morphology?

Sickle Cell Anemia

Match the disease condition title with the appropriate number of abnormal alpha thalassemia genes that are inherited.

-Alpha Thalassemia Trait

-Hydrops Fetalis

-Hemoglobin H Disease

-Silent Carrier

2 abnormal genes

4 abnormal genes

3 abnormal genes

1 abnormal gene

Hemoglobinopathies are characterized by:

structural abnormality of the globin chains

Which of the following globin chain configurations is characteristic of Hgb H?

4 beta

Sickle cell anemia is represented by which of the following types of hemoglobin?

SS

The anemia seen in sickle cell disease is usually

normocytic / normochromic

The RBC morphology seen in Aplastic Anemia is:

normocytic / normochromic

What is the treatment for a Folate Deficiency?

folic acid

Megaloblastic Anemias are classified as:

macrocytic / normochromic

A Vitamin B12 deficiency can result from a gastrectomy because this procedure will decrease or eliminate what substance?

intrinsic factor

An anemia is defined as a decreased amount of hemoglobin in the blood which therefore decreases the amount of oxygen reaching the tissues and organs. T? F?

True