First line Antihypertensives: ARBs (Angiotensin II receptor blockers)

ARBs

block angiotensin II receptor type 1 (AT1) from producing its affects, angiotensin II still made

ARBs outcome

same as ACEi: less aldosterone, less vasoconstriction, and less sympathetic activity

suffix of ARBs

sartan

indication of ARBs

first line antihypertensives, myocardial infarction, and heart failure

contraindications of ARBs

none

black box warning of ARBs

pregnancy

ADR (common) of ARBs

hyperkalemia, acute kidney injury, and dizziness

ADR (rare) of ARBs

angioedema and rhabdomyolysis

counseling points of ARBs

no pregnancy, potassium/salt supplements, and causes dizziness

similarities of ACEi and ARBs

blocks same RAAS system, ADR, and no pregnancy

difference b/t ACEi and ARBs

ACEi blocks production of angiotensin II causing buildup of bradykinin → DRY COUGH

ARBs block AT1 receptor and does not cause dry cough