1.9 Important Class Interactioins

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Last updated 8:45 PM on 8/27/26
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6 Terms

1
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What important Top 200 drugs interact with ACE inhibitors in the Week 2 list?

Aliskiren, sacubitril/valsartan, and trimethoprim.

2
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Why should an ACE inhibitor not be taken with sacubitril/valsartan (Entresto)?

The combination increases the risk of angioedema.

3
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How long should you wait between stopping an ACE inhibitor and starting Entresto?

At least 36 hours.

4
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What potassium-related interaction should you watch for with RAAS-blocking drugs?

Combining them with potassium-increasing drugs can increase the risk of hyperkalemia.

5
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What important interaction is listed for spironolactone?

Triamterene — combining potassium-sparing diuretics increases hyperkalemia risk.

6
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What important interactions are listed for triamterene/HCTZ?

Cyclosporine, potassium salts, and other potassium-sparing diuretics such as spironolactone.