autoimmunity diagnosis & interpretation

diffuse scleroderma is associated with which antigenic determinant?

DNA topoisomerase I

The RF antibody is helpful in evaluating patients who may have rheumatoid arthritis because the sensitivity and specificity for RA are both around ____%.

70

The presence of which antibody is around 95% specific and 70% sensitive for rheumatoid arthritis?

anti-cyclic citrullinated peptide (anti-CCP)

The ______ produces about 15 grams of albumin per day.

liver

Around ______% of patients with rheumatoid arthritis do not test positive with rheumatoid factor.

15

The existence of these antibodies LAC, aCL, and aPL are associated with

APS

Which of the following is not a pro-inflammatory cytokine listed in the article as an inducer of acute phase reactants?

C-reactive protein (CRP)

the ____ and ____ nuclear antigens are often found together in patients with Sjogrens.

SSA and SSB

Ceruloplasmin plays a role in ______ metabolism.

iron

Which of the following was not specifically named in the article as a potential cause of an elevated ferritin level?

colon cancer

Quantitative measurements of serum immunoglobulins are measured via _______.

nephelometry

_____ is characterized by systemic granulomatous vasculitis lesions of the upper and lower respiratory tract and the kidney.

WG

Paroxysmal cold hemoglobinuria is associated with which of the following laboratory findings?

reticulocytosis

Anti-CCP can be present in all the following except?

lymphoma

All of the following are ANA fluorescent patterns except?

Heterogenous

Rheumatoid factor is an autoantibody that reacts to

The Fc portion of polyclonal IgG

Which of the following was not listed as “most often seen” with antineutrophil cytoplasmic antibodies (ANCA) that react with cytoplasmic granules of neutrophils?

sjogrens

around ___% of patients with lupus will be positive with histone.

50

The ______ hallmarks the serologic diagnosis of SLE, but finding an ____ is common to most autoimmune diseases.

ANA

Haptoglobin is produced in response to

tissue injury

hypercalcemia can be observed in approximately _____% of patients with sarcoidosis.

30

Which of the following tests are listed in the article as helpful in a sarcoidosis diagnosis?

vitamin D + one more

Idiopathic thrombocytopenic purpura (ITP) is thought to occur to all of the following EXCEPT…

Decreased megakaryocytes

Diagnosis of _____ is confirmed by tissue or aspiration biopsy of the affected organ looking for birefringent material on congo red stain.

amyloidosis

Fibrinogen is mediated by inflammation and stress that is mediated by IL-___.

6

_____ due to the presence of warm agglutinins is almost always due to IgG antibodies that react with protein antigens on the erythrocyte surface at body temperature (37 degree Celsius).

AIHA

_____ is used to test for ANA using a cell substrate, HEP2 cells.

immunofluorescence

What is the assay that evaluates the functional integrity of the classical pathway?

CH50

what are two complement proteins that can be increased in the serum during inflammation as they are acute phase reactants?

C3 and C4

What immunoglobulin precipitates reversibly in cold temperatures and bind to complement proteins to form immune complexes causing tissue damage?

cyoglobulins

what type of Cryoglobulins are associated with multiple myeloma, waldenstrom’s macroglobilinemia, and lymphoproliferative disorders?

type 1 monoclonal cryoglobulins

what types of Cryoglobulins can bind to compliment proteins and are associated with hepatitis C and small vessel vasculitis?

type 2 and 3

what is the syndrome suspected in individuals that have arterial thromboses, recurrent fetal loss, or thrombocytopenia?

anti-phospholipid antibody syndrome

what is the test that measures that quantity of RBCs that precipitate in a tube and is important for evaluating inflammatory states?

erythrocyte sedimentation rate (ESR)

what is the antibody that reacts with the Fc portion of an immunoglobulin