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Central Nervous System (CNS)
Consists of the brain and spinal cord; the body's major decision-making and information-processing center.
Peripheral Nervous System (PNS)
All nerves connecting the CNS to the rest of the body; carries information body → CNS and CNS → body.
Nerve
A bundle of axons that carries information through the peripheral nervous system.
Sensory Neuron (Afferent Neuron)
Carries incoming sensory information from receptors in the body → CNS.
Motor Neuron (Efferent Neuron)
Carries outgoing commands from the CNS → muscles and glands.
Interneuron
Neuron located mainly in the brain and spinal cord that processes information and communicates between sensory and motor neurons.
Sensory → Interneuron → Motor
The basic information pathway: sensory neurons bring information to the CNS, interneurons process it, and motor neurons carry commands out.
Somatic Nervous System
Division of the PNS that controls skeletal muscles and primarily enables voluntary movement.
Autonomic Nervous System (ANS)
Division of the PNS controlling involuntary functions of internal organs, glands, and smooth muscles; includes sympathetic and parasympathetic divisions.
Sympathetic Nervous System
Division of the autonomic nervous system that arouses the body and prepares it for action; "fight or flight."
Parasympathetic Nervous System
Division of the autonomic nervous system that calms the body, conserves energy, and returns the body toward its resting state; "rest and digest."
Reflex
Automatic response to sensory stimulation that can be rapidly coordinated through the spinal cord without waiting for conscious processing.
Reflex Arc
Sensory receptor → sensory neuron → spinal-cord interneuron → motor neuron → muscle.
Neuron Signal Direction
Dendrites → cell body → axon → terminal branches → synapse.
Dendrites
Branches extending from the cell body that receive and integrate incoming information and carry it toward the cell body.
Cell Body (Soma)
Neuron's life-support center; contains the nucleus.
Axon
Long extension from the cell body that carries neural impulses away from the cell body toward other neurons, muscles, or glands.
Myelin Sheath
Fatty tissue covering portions of some axons; speeds neural impulses.
Glial Cells (Glia)
Support cells that nourish and protect neurons, support neural communication, help form myelin, and participate in learning and thinking.
Resting Potential
Electrical charge difference across a neuron's membrane when it is not firing; the neuron is polarized.
Action Potential
Brief electrical charge that travels down an axon; neural communication within a neuron is electrical.
Depolarization
Change in the neuron's membrane charge when positively charged ions flow in, helping initiate the action potential.
Threshold
Minimum level of stimulation required to trigger an action potential.
All-or-None Response
Once threshold is reached, a neuron fires completely; stronger stimulation does not create a larger individual action potential.
How Does a Stronger Stimulus Affect Neural Firing?
It can cause more neurons to fire and/or increase firing frequency; it does not make an individual action potential larger.
Refractory Period
Brief period immediately after firing when the neuron must reset and temporarily cannot fire normally again.
Synapse
Junction where one neuron communicates with another; neurons generally do not physically touch.
Synaptic Gap (Synaptic Cleft)
Tiny space between the sending neuron's terminal and the receiving neuron across which neurotransmitters travel.
Neurotransmitter
Chemical messenger released by a neuron that crosses the synaptic gap and influences a receiving neuron.
Neurotransmission
Action potential reaches terminal → neurotransmitters released → cross synaptic gap → bind to receptors → influence receiving neuron.
Electrical vs. Chemical Neural Communication
Communication within a neuron is electrical; communication between neurons across a synapse is chemical.
Receptor Site
Location on a receiving neuron where a neurotransmitter binds and influences that cell.
Reuptake
Process in which neurotransmitters released into the synapse are reabsorbed by the sending neuron; drugs can alter this process.
Acetylcholine (ACh)
Neurotransmitter involved in muscle action, learning, and memory. Memory aid: ACh = Action of muscles.
Dopamine
Neurotransmitter involved in movement, learning, attention, emotion, and reward.
Serotonin
Neurotransmitter involved in mood, hunger, sleep, and arousal.
Norepinephrine
Neurotransmitter involved especially in alertness and arousal.
GABA
Major inhibitory neurotransmitter; reduces neural activity.
Glutamate
Major excitatory neurotransmitter; important for learning and memory.
Endorphins
Natural opiate-like neurotransmitters produced by the body; involved in pain reduction and pleasure.
Agonist
A substance that increases or mimics a neurotransmitter's action.
Antagonist
A substance that blocks a neurotransmitter's action.
Endocrine System
The body's slower chemical communication system; glands release hormones that travel through the bloodstream.
Hormones
Chemical messengers released by endocrine glands and carried through the bloodstream.
Nervous System vs. Endocrine System
Nervous: neurons, electrochemical, very fast, neural pathways, often brief effects. Endocrine: hormones, chemical, bloodstream, slower, often longer-lasting effects.
Pituitary Gland
Small endocrine gland associated with the brain; called the "master gland" because it influences other endocrine glands; controlled/influenced by the hypothalamus.
Hypothalamus → Pituitary → Endocrine Glands
The hypothalamus controls/influences the pituitary, which in turn influences other endocrine glands.
Adrenal Glands
Endocrine glands located on top of the kidneys; release stress-related hormones including epinephrine/adrenaline and norepinephrine.
Adrenal Gland Functions
Release stress hormones that can increase heart rate, blood pressure, and available energy.
Psychoactive Drug
Chemical substance that alters perception, mood, or consciousness by affecting neural activity.
Substance Use Disorder
Continued craving or use of a substance despite significant life disruption or physical risk.
Tolerance
With repeated use, the same drug dose produces a smaller effect, so more may be needed to achieve the previous effect.
Withdrawal
Unpleasant physical or psychological symptoms that may occur when a person who has developed dependence stops using a substance.
Addiction
Compulsive craving and use of a substance despite harmful consequences.
Three Major Psychoactive Drug Categories
Depressants decrease CNS activity; stimulants increase neural activity; hallucinogens distort perceptions.
Depressants
Drugs that reduce CNS/neural activity and slow bodily functions; examples include alcohol, barbiturates, and opioids.
Alcohol
Depressant that slows CNS activity and neural processing; can impair judgment, memory, and coordination and reduce inhibition.
Why Can Alcohol Make Someone Appear Excited if It Is a Depressant?
It can depress brain systems responsible for inhibition and self-control, causing louder or riskier behavior despite slowing CNS activity.
Barbiturates
Depressants that reduce CNS activity and anxiety but can impair memory and judgment; large amounts can dangerously suppress breathing.
Opioids
Depressants that slow neural activity and can produce pain relief and euphoria; interact with systems associated with natural endorphins.
Stimulants
Drugs that increase neural activity and speed bodily functions; can increase heart rate, blood pressure, energy, and alertness.
Caffeine
Stimulant that increases wakefulness, alertness, and arousal; withdrawal can include headaches, fatigue, and irritability.
Nicotine
Highly addictive stimulant that can increase alertness and arousal and reaches the brain rapidly.
Cocaine
Powerful stimulant that can produce euphoria, energy, confidence, and increased arousal; strongly affects reward pathways and may be followed by a crash.
Amphetamines
Stimulants that increase neural activity, energy, and alertness.
Methamphetamine
Powerful addictive stimulant that can produce intense stimulation, euphoria, energy, and increased arousal.
MDMA (Ecstasy)
Drug with stimulant and mild hallucinogenic effects; strongly affects serotonin systems.
Hallucinogens
Drugs that distort perceptions and may create sensory experiences without corresponding sensory input.
LSD
Powerful hallucinogen that alters sensations, perceptions, and experiences of reality.
THC
Marijuana's major psychoactive ingredient; can cause relaxation, altered perception/time, and impaired memory and coordination.
Marijuana
can alter perception, sense of time, memory, and coordination and may produce relaxation.
Lesion
Destruction of brain tissue; researchers examine resulting changes in abilities to infer the damaged area's function.
EEG (Electroencephalogram)
Uses electrodes on the scalp to measure electrical brain activity; useful for brain waves, sleep, and seizures.
MEG (Magnetoencephalography)
Measures magnetic fields produced by neural activity.
CT Scan
Uses X-rays to show brain structure and identify structural abnormalities.
PET Scan
Uses radioactive glucose to reveal brain activity; more active areas consume more energy/glucose.
MRI
Uses magnetic fields and radio waves to produce detailed images of brain structure/anatomy.
fMRI (Functional MRI)
Tracks blood-flow-related changes to show brain function/activity while also providing structural information.
MRI vs. fMRI
MRI primarily shows brain structure/anatomy; fMRI shows function/activity associated with blood-flow changes.
Hindbrain
Brain division associated with essential survival-related functions; includes the medulla, pons, and cerebellum.
Midbrain
Brain division involved in connecting brain regions and in movement and sensory functions.
Forebrain
Brain division associated with more complex processing and higher-level functions.
Brainstem
Lowest central region of the brain connecting the spinal cord with higher brain regions; controls many automatic survival functions.
Medulla
Located at the very bottom of the brainstem directly above the spinal cord; controls heartbeat and breathing.
Pons
Located above the medulla; coordinates movement and helps regulate sleep.
Reticular Formation
Neural network running through the brainstem toward the thalamus; filters incoming stimulation and regulates arousal and alertness; severe disruption can cause coma.
Thalamus
Located on top of the brainstem; major sensory relay station that routes sensory information toward appropriate cortical areas, except smell.
Which Sense Is the Major Exception to the Thalamus?
Smell; it does not follow the same initial thalamic relay pathway as the other major senses.
Cerebellum
Located behind the brainstem; coordinates balance, smooth voluntary movement, and procedural/nonverbal learning and memory.
Cerebellum vs. Hippocampus
Cerebellum: procedural/skill learning and coordination. Hippocampus: formation/processing of new explicit memories.
Limbic System
Located largely beneath the cerebral cortex in the forebrain; associated with emotion, motivation/drives, and memory.
Amygdala
Two small neural clusters deep in the limbic region; especially associated with fear, aggression, and emotional processing.
Hypothalamus
Located below the thalamus; regulates hunger, thirst, body maintenance, temperature/homeostasis, reward, emotion, and endocrine activity; controls the pituitary.
Hypothalamus Location
Located below the thalamus
Hippocampus
Located deep in the brain in the medial temporal/limbic region; processes and helps form new explicit memories of facts and events.
Explicit Memory
Consciously recalled memories of facts and events; formation of new explicit memories is strongly associated with the hippocampus.
Pituitary Gland Location
Small gland located beneath and connected with the hypothalamus.
Cerebral Cortex
Thin outer layer of the cerebral hemispheres; responsible for sophisticated information processing.
Four Lobes of the Cerebral Cortex
Frontal, parietal, occipital, and temporal lobes.
Frontal Lobe
Located behind the forehead; involved in planning, judgment, decision-making, speaking, voluntary movement, and higher cognition.