PMQA LAB PT 3

Capping

Partial separaton on bottom of Top or bottom. Caused by poor compression, high tablet press speed, excessive air entrapment

Lamination

Separation to 2 or more distinct layers

Usually in a horzontal lane. This can also be caused by sir entrapment.

add sorbitol, methylcellulose, polyethylene glycol

What to add to fix lamination

Cracking

In concave tablets Visible cracks on the surface of the tablets. Caused by rapid expansion of tablets

Sticking

Adhesion of material to Die wail or Face of the punch

Picking

adhesion of material to the design, embedded on the punch tip

Chipping

Removal small portion of tablet edges

Double impression

two engravings on the surface

Double impression

The score line or the logo appears twice, caused by punch misalignment or improper tablet press orientation. Install anti-rotation devices to prevent misalignment

Mottling

Uneven color distribution

• Inadequate mixing of the dye.

• Raw materials that are light-sensitive.

• Improper drying technique.

Factors that cause mottling:

COATING DEFECTS

Occur when the outer layer of the tablet, which is applied for protection, appearance, or controlled release, Does not meet quality standards

Mottling

Uneven color distribution

Sweating

Oily fim or droplets

Bridging

The markings are obscured

Erosion

Removal of coating from the tablet surface

Cratering

craters appears exposing the tablet surface

Blistering

Reduced adhesion and detachment of the film

Blooming

Fading or dulling of the film.

Twinning

Two tablets stick together

Orange peel

Rough, non-glossy surface

Flaking

Film of the tablet flakes off, exposing the tablet surface

Type I

Flaking due to thermal expansion

Type II

Flaking due to core swelling

Delayed distribution

Exposure of tablet cores due to coating process conditions rather than the direct effect of the coating.

Telescoping

occurs when one end of the capsule’s body or cap slips over the other, causing improper closure and an unsightly appearance. This defect can occur during the filling or sealing process of hard gelatin or other types of capsules.

Overdrying

Type I is caused by

extreme moisture upatke

Type II is caused by