Coagulation Cascade

What are the 3 types of coagulation pathways?

Intrinsic

Extrinsic

Common

The intrinsic pathway is activated by what?

When factor XII is exposed to collagen

The Extrinsic pathway is activated by?

Injury to the epithelial tissue

What is the common pathway a result of?

Activation of factor X from either pathway

What factors are involved in the intrinsic pathway?

XII, XI, IX and VIII

Which factors are involved in the extrinsic pathway?

VII and III

What factors are involved in the common pathway?

X, V, II, I and XIII

What factors are associated with Haemophilia A?

VIII

Which factor/factors are associated with Haemophilia B?

IX

Which factor/factors is associated with Haemophilia C?

XI

Which factor/factors is associated with von Willebrand Disease?

VIII

Which factor/factors is associated with Vitamin K Deficiency?

IX (intrinsic) VII (Extrinsic) X and II (common)

What is another name for factor III

Tissue Factor

What is another name for Factor XII?

Hageman factor

The Extrinsic pathway begins with the release of ____by endothelial cells, which combines with ____ and ____ to from an active enzyme

Tissue factor, VII and Ca+

In the Common pathway, _____ and ____ React with ____ to turn prothrombin in thrombin

V, X with Ca+

The Kallikrein and Fitzgerald factor combine at the beginning of the _____ to create ____.

Intrinsic pathway, XII

What is intimated when other plasma coagulation factors contact the materials posed when the blood vessel is damaged?

Intrinsic pathway