ch 4 substitution and elimination

strong base, weak nucleophile lead to what reaction

E2

strong base, strong nucleophile with primary substitution lead to what reaction

SN2 or E2 but SN2 preferred

strong base, strong nucleophile with secondary substitution lead to what reaction

SN2 and E2 but E2 preferred

strong base, strong nucleophile with teritary substitution lead to what reaction

E2

weak base, strong nucleophile with primary or secondary substitution lead to what reaction

SN2

weak base, strong nucleophile with teritary substitution lead to what reaction

SN1

weak base, weak nucleophile with primary substitution lead to what reaction

no reaction

weak base, weak nucleophile with secondary or tertiary substitution under cold temp lead to what reaction

SN1

weak base, weak nucleophile with secondary or tertiary substitution under cold temp lead to what reaction

E1

strong base, weak nucleophile reagents

NaH, DBN, DBU, LDA, t-BuOK, N,N-diisopropylethylamine

strong base, strong nucleophile reagents

RO-, HO-, MeO-, EtO-

weak base, strong nucleophile reagents

I-, Br-, CL-, RS-, HS-, RSH, H2S, NaCN, NaSEt, NaN3

weak base, weak nucleophile reagents

H2O, MeOH, EtOH, ROH

rate law for SN2

rate = k[nucleophile][electrophile]

rate law for SN1

rate = k[electrophile]

rate law for E2

rate = k[base][substrate]

rate law for E1

rate = k[substrate]

What product is formed if base is unhindered and is it more or less substituted?

Zaitsev Product, more substituted alkene

What product is formed if base is bulky and is it more or less substituted?

Hofmann Product, less substituted alkene