bone & joint drug adverse effects

NSAIDs (9)

anorexia, N/V, stomach pain, rash, GI bleeding/ulcers, fluid retention, CV events, decreased renal function, and heartburn

aspirin OD (2)

tinnitus and vertigo

methotrexate (5)

infection, hepatic fibrosis, bone marrow suppression, GI ulcers, and teratogenic

sulfasalazine

GI effects

leflunomide (3)

diarrhea, rash, and hair loss

hydroxychloroquine

retinal damage/blindness

etanercept (4)

infection, TB, HF, and cancer

infliximab (6)

infections, HF, liver failure, anaphylaxis, flu-like, and hypotension

colchicine (3)

N/V/D, thrombocytopenia, and rhabdomyolysis

allopurinol (5)

N/V, drowsiness, HA, metallic taste, and hypersensitivity syndrome (rare)

febuxostat (4)

nausea, rash, arthralgia, and liver problems

belimumab (6)

N/V/D, HA, depressed mood, insomnia, infusion reaction, and infection

SNRIs (6)

nausea, HA, HTN, tachycardia, withdrawal, and sexual dysfunction

pregabalin (7)

increased appetite, weight gain, constipation, hypersensitivity, angioedema, rhabdomyolysis, and sexual dysfunction

biphosphonates (3)

esophageal ulcers, MS pain, and atypical femoral fractures

raloxifene (3)

venous thromboembolism, teratogenic, and hot flashes