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peristalsis
Waves of contraction/relaxation moving food through digestive tract
bolus
Mass of chewed food
chyme
Semi-digested food from stomach to duodenum
villus (villi)
Hairlike projections in small intestine for absorption
hepatitis
Inflammation of the liver (A, B, C types)
cirrhosis
Irreversible scarring of liver (alcohol, hepatitis, fatty liver)
cholelithiasis
Gallstones
GERD
Gastroesophageal reflux disease (acid reflux)
peptic ulcer
Mucosal breakdown in stomach or duodenum (often H. pylori)
Crohn's disease
Chronic inflammation of small intestine (often ileum)
ulcerative colitis
Chronic inflammation and ulceration of large intestine
CNS
Central nervous system (brain + spinal cord)
PNS
Peripheral nervous system (nerves outside CNS)
afferent
Toward CNS (sensory)
efferent
Away from CNS (motor)
sympathetic division
Fight or flight; increases heart/respiratory rate
parasympathetic division
Rest and digest; slows heart/respiratory rate, stimulates digestion
neuron
Nerve cell with cell body, dendrites (receive), axon (send)
synapse
Junction between neurons where neurotransmitters cross
neurotransmitter
Chemical that crosses synapse (norepinephrine, serotonin, dopamine)
blood-brain barrier
Prevents toxins from affecting brain
frontal lobe
Behind forehead; voluntary motor control, intellect, planning, behavior
parietal lobe
Receives/interprets sensory info (touch, taste, smell, hearing, sight)
temporal lobe
Language, emotions, sensory experiences
occipital lobe
Visual images and written words
thalamus
Sensory relay station
hypothalamus
Regulates BP, body temperature, water/electrolyte balance
cerebellum
Posture, balance, coordination
meninges
Dura mater (outer), arachnoid mater (middle), pia mater (inner)
Alzheimer disease
Most common dementia; protein clumps/tangles
ischemic stroke
~90% of strokes; caused by plaque or clot
hemorrhagic stroke
Blood vessel bursts or aneurysm ruptures
TIA (transient ischemic attack)
Mini-stroke; symptoms
FAST
Face droop, Arm drift, Speech slurred, Time to call 911
hemiplegia
Paralysis of one side of the body
Parkinson disease
Dopamine deficiency; tremor, rigidity, shuffling gait
multiple sclerosis (MS)
Autoimmune demyelination; exacerbations and remissions
meningitis
Inflammation of meninges; viral or bacterial
Bell palsy
CN VII (Facial); sudden one-sided facial paralysis
trigeminal neuralgia
CN V (Trigeminal); severe facial pain
quadriplegia
All four limbs paralyzed
paraplegia
Both lower extremities paralyzed
cerebral palsy
Motor impairment from brain damage in infant/young child
hydrocephalus
Excess CSF in ventricles; treatment = shunt
spina bifida
Vertebral arch fails to close
psychosis
Loss of contact with reality
schizophrenia
Form of psychosis; hallucinations + delusions
major depression (unipolar)
Deep sadness/hopelessness for ≥2 weeks
bipolar disorder
Alternating depression + mania
PTSD
After trauma; flashbacks, nightmares, emotional numbness
OCD
Obsessions (recurrent thoughts) + compulsions (irresistible urges)
agoraphobia
Fear of crowded places
antisocial personality disorder
Lie, cheat, steal; no guilt
SSRI
Selective serotonin reuptake inhibitor (Prozac, Zoloft); depression, anxiety
benzodiazepine
Valium, Xanax, Ativan; anxiety and panic disorder (rapid onset)
EEG
Electroencephalography; records brain's electrical activity
cornea
Transparent, avascular; provides ~60% of eye's focusing power
lens
Changes shape (accommodation) to focus light; loses elasticity with age
retina
Contains rods (dim light, no color) and cones (bright light, color)
fovea centralis
Sharpest vision; 4,000 tiny cones, no rods
optic disc
Blind spot; no rods or cones
glaucoma
Fluid cannot drain → pressure builds → damages optic nerve; major cause of blindness
cataract
Cloudy lens; caused by aging, diabetes, smoking; major cause of blindness
macular degeneration
Loss of central vision; most cases >55
retinal detachment
Surgical emergency; dark shadow in peripheral vision
diabetic retinopathy
~50% of diabetics; hemorrhages destroy photoreceptors
papilledema
Swelling of optic disc due to increased intracranial pressure
PERRLA
Pupils Equal, Round, Reactive to Light and Accommodation
Snellen chart
Distance vision test at 20 feet
tympanic membrane (eardrum)
Vibrates with sound waves
malleus, incus, stapes
Hammer, anvil, stirrup (ossicles of middle ear); stapes is smallest bone
eustachian tube
Connects middle ear to nasopharynx; short/horizontal in children <5
cochlea
Snail-shell; converts vibrations to nerve impulses (hearing)
semicircular canals
Detect rotational movement (balance)
otitis externa
Infection of external auditory canal (swimmer's ear)
acute otitis media (AOM)
Middle ear infection; ages 2-4; after URI
otosclerosis
Spongy bone at oval window + stapes; conductive hearing loss
sensorineural hearing loss
Damage to cochlear hair cells; most common cause = repeated loud noise
vertigo
Sensation of spinning
tinnitus
Ringing in the ears
Meniere disease
Vertigo + tinnitus + hearing loss
Rinne test
Tuning fork test distinguishes bone vs. air conduction
Weber test
Tuning fork test identifies which side hearing loss is on
endocrine system
Ductless glands that secrete hormones directly into bloodstream
hypothalamus
Connects brain to endocrine system; produces releasing hormones, oxytocin, ADH
pineal gland
Secretes melatonin at night; regulates sleep-wake cycles
FSH, LH, TSH, ACTH, prolactin, GH
Six anterior pituitary hormones
oxytocin (OT)
Posterior pituitary; uterine contractions, milk ejection, bonding
ADH
Posterior pituitary; reduces urine volume (vasopressin)
diabetes insipidus
ADH deficiency → excessive dilute urine; NOT diabetes mellitus
T3, T4
Thyroid hormones; increase metabolic rate
calcitonin
Lowers blood calcium (bone deposition)
PTH (parathyroid hormone)
Raises blood calcium (bone resorption)
insulin
ONLY hormone that lowers blood glucose
glucagon
Raises blood glucose
Type 1 diabetes (IDDM)
Autoimmune beta cell destruction; onset <30 years; insulin-dependent
Type 2 diabetes (NIDDM)
Insulin resistance; up to 95% of DM
DKA (diabetic ketoacidosis)
Hyperglycemia + dehydration + metabolic acidosis + ketones; medical emergency; acetone breath
hyperglycemia
High blood glucose; polyuria, polydipsia, polyphagia
hypoglycemia
Low blood glucose (<70 mg/dL); brain first organ affected