GI Top 300: Quiz 1

What is the brand for Dexlansoprazole?

Dexilant

What is the drug class for Dexlansoprazole?

PPI

What are the dosage forms for Dexlansoprazole?

DR Capsule

What are the on-label uses for Dexlansoprazole?

Erosive Esophagitis Treatment

Symptomatic GERD

What are the off-label uses for Dexlansoprazole?

Eosinophilic Esophagitis Treatment

What is the MOA for Dexlansoprazole?

PPI that covalently binds to H+.K-ATPase which is the final pathway for acid secretion

What are the box warnings for Dexlansoprazole?

None

What are the contraindications for Dexlansoprazole?

Hypersensitivity to Dexlansoprazole or other PPIs

Concurrent use of Rilpivirine

Is Dexlansoprazole safe for pregnancy/lactation?

Pregnancy: low risk

Lactation: potential toxicity

What are the adverse effects for Dexlansoprazole?

None

What is the brand for Esomeprazole?

Nexium

What is the drug class for Esomeprazole?

PPI

What are the dosage forms for Esomeprazole?

DR Capsule, DR Tablet, Oral Packet

What are the on-label uses for Esomeprazole?

- H.Pyrlori GI Infection

- GERD Treatment

- Heartburn

- Prevention of NSAID-induced gastropathy

- Zollinger-Ellison Syndrome

What are the off-label uses for Esomeprazole?

- PUD

- Eosinophilic Esophagitis

What is the MOA for Esomeprazole?

- PPI that covalently binds to H+/K+-ATPase which is the final pathway for acid secretion

- Inhibits basal, nocturnal, pentagastrin-stimulated, and food-stimulated gastric acid secretion

What are the box warnings for Esomeprazole?

None

What are the contraindications for Esomeprazole?

Hypersensitivity to Omeprazole or Esomeprazole

Concurrent Rilpivirine

Is Esomeprazole safe for pregnancy/lactation?

Pregnancy: low risk

Lactation: potential toxicity

What are the adverse effects for Esomeprazole?

Headache

What is the brand for Lansoprazole?

Prevacid

What is the drug class for Lansoprazole?

PPI

What are the dosage forms for Lansoprazole?

DR Capsule, DR ODT

What are the on-label uses for Lansoprazole?

- Duodenal Ulcer Disease

- Gastric Ulcer Disease Treatment

- H.pyrlori GI Tract Infection

- Erosive Esophagitis GERD Treatment

- Zollinger-Ellison Syndrome

What are the off-label uses for Lansoprazole?

Heartburn

Eosinophilic Esophagitis

What is the MOA for Lansoprazole?

PPI that when protonated in the secretory canaliculi of the parietal cells, covalently binds to H+/K+-ATPase

What are the box warnings for Lansoprazole?

None

What are the contraindications for Lansoprazole?

Hypersensitivity

Concurrent use of Rilpivirine

Is Lansoprazole safe for pregnancy/lactation?

Pregnancy: low risk

Lactation: potential toxicity

What are the adverse effects for Lansoprazole?

None

What is the brand for Pantoprazole?

Protonix

What is the drug class for Pantoprazole?

PPI

What are the dosage forms for Pantoprazole?

DR Tablet, Oral Packet

What are the on-label uses for Pantoprazole?

GERD

Zollinger-Ellison Syndrome

What are the off-label uses for Pantoprazole?

H.pylori GI tract

Duodenal Ulcer Disease

What is the MOA for Pantoprazole?

PPI that gets protonated in the secretory canaliculi of the parietal cells and covalently binds to H"/K"-ATPase

What are the box warnings for Pantoprazole?

None

What are the contraindications for Pantoprazole?

Hypersensitivity to Pantoprazole

Concurrent Rilpivirine use

Is Pantoprazole safe for pregnancy/lactation?

Pregnancy: low risk

Lactation: compatible

What are the adverse effects for Pantoprazole?

Headache

What is the brand for Rabeprazole?

AcipHex

What is the drug class for Rabeprazole?

PPI

What are the dosage forms for Rabeprazole?

DR Tablet, Sprinkle Capsule

What are the on-label uses for Rabeprazole?

- PUD

- H.pylori GI infection

- Gastric Hypersecretion

- Erosive or Ulcerative GERD

What are the off-label uses for Rabeprazole?

- DYspepsia

- Eosinophilic Esophagitis

What is the MOA for Rabeprazole?

PPI that, when protonated in the secretory canaliculi of the parietal cells, covalently binds to H+/K+-ATPase (proton pump)

What are the box warnings for Rabeprazole?

None

What are the contraindications for Rabeprazole?

Hypersensitivity to Rabeprazole

Concomitant Rilpivirine

Is Rabeprazole safe for pregnancy/lactation?

Pregnancy: low risk

Lactation: potential toxicity

What are the adverse effects for Rabeprazole?

Abdominal pain, diarrhea, vomiting