genetic expression
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8 Terms
effect of decreased acetylation of histones
DNA not accessible to transcription factors
effect of increased methylation on transcription
inhibits transcription
how does increased methylation inhibit transcription
prevents binding of transcriptional factors
attracts proteins that condense DNA-histone complex
what happens when a gene is switched off
DNA blocked by an inhibitor, so RNA polymerase cant bind
oestrogen role
lipid soluble so diffuses across the phospholipid bilayer, forms oestrogen-receptor complex, acts as a transcriptional factor
how can a gene be inhibited even after transcription
siRNA
how does siRNA work
binds to complementary sequence of mRNA, causing it to become double-stranded, viewed as abnormal, so broken down by enzymes