Top 300 Drugs – Cholesterol Lowering Medications

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Last updated 2:36 AM on 8/4/26
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17 Terms

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Atorvastatin

Brands = Lipitor

Drug Class = Statin

Typical Uses = ↓ CV Events

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Lovastatin

Brands = Mevacor, Altoprev

Drug Class = Statin

Typical Uses = ↓ CV Events

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Pravastatin

Brands = Pravachol

Drug Class = Statin

Typical Uses = ↓ CV Events

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Rosuvastatin

Brands = Crestor

Drug Class = Statin

Typical Uses = ↓ CV Events

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Simvastatin

Brands = Zocor

Drug Class = Statin

Typical Uses = ↓ CV Events

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Ezetimibe/Simvastatin

Brands = Vytorin

Drug Class = Combo (Chol-abs inhib + statin)

Typical Uses = ↓ CV Events

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Ezetimibe

Brands = Zetia

Drug Class = Cholesterol-absorption inhibitor

Typical Uses = ↓LDL

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Fenofibrate

Brands = Tricor

Drug Class = Fibrate

Typical Uses = ↓TG, ↑HDL

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Gemfibrozil

Brands = Lopid

Drug Class = Fibrate

Typical Uses = ↓TG, ↑HDL

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Omega-3-acid ethyl esters

Brands = Lovaza

Drug Class = Omega-3 FA (Fish Oil)

Typical Uses = ↓TG

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Niacin (ER)

Brands = Niaspan

Drug Class = Vitamin B3

Typical Uses = ↑HDL, ↓TG/LDL

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Alirocumab

Brands = Praluent

Drug Class = PCSK9 inhibitor

Typical Uses = ↓LDL (inject)

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Evolocumab

Brands = Repatha

Drug Class = PCSK9 inhibitor

Typical Uses = ↓LDL (inject)

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Mechanism / Therapeutic Rationale

• Statins: dramatic LDL-C drop. ✓ mortality benefit

• Ezetimibe: ↓cholesterol absorption; add-on to statins.

• Fibrates: ↓TG, modest ↑HDL.

• Niacin: ↑HDL, ↓TG.

• Omega-3 FA: ↓hepatic TG.

• PCSK9i: profound LDL-C ↓

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Hallmark Common SEs

• Statins: GI upset, myalgias

• Fibrates: dyspepsia

• Niacin: flushing

• Omega-3: fishy taste, GI

• PCSK9i: injection-site erythema

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Serious / Black-Box Risks

Statins/Fibrates/Niacin/Ezetimibe (+statin): myopathy → rhabdomyolysis

Hepatotoxicity (statins, niacin, fibrates) – monitor LFTs

PCSK9i: hypersensitivity / anaphylaxis (rare)

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High-Yield Interactions & Contra-Indications

• CYP3A4 inhibitors (azoles, macrolides, grapefruit juice) ↑ ator-/sim-/lova-statin levels → myopathy.

• Fibrates markedly ↑ statin myopathy risk – avoid combo.

• Absolute CI: active liver disease, pregnancy (statins); seafood allergy (omega-3).